Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid

You, Hua; Huang, Chih-Fang; Chen, Chung‐Jen; Chang, Chiung Chih; Liao, Pei-Lin; Huang, Sheng‐Teng

doi:10.1016/j.jcma.2017.11.007

Cited by 73 publications

(38 citation statements)

References 24 publications

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“…Chlorogenic acid and gallic acid have also been demonstrated to suppress the in vitro and in vivo replication of influenza A virus, enterovirus 71 and hepatitis B and C viruses (Ding et al, 2017;Wang et al, 2009;You et al, 2018;Govea-Salas et al, 2016). Chlorogenic acid specifically inhibited the neuraminidase activity of influenza A viruses H1N1 and H3N2 that was the crucial mechanism of chlorogenic acid for blocking the release of progeny virions from infected cells (Ding et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

et al. 2019

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Human coronavirus NL63 (HCoV-NL63), one of the main circulating HCoVs worldwide, causes respiratory tract illnesses like runny nose, cough, bronchiolitis and pneumonia. Recently, a severe respiratory illness outbreak of HCoV-NL63 has been reported in a long-term care facility. Sambucus FormosanaNakai, a species of elderberry, is a traditional medicinal herb with anti-inflammatory and antiviral potential. The study investigated the antiviral activity of Sambucus FormosanaNakai stem ethanol extract and some phenolic acid constituents against HCoV-NL63. The extract was less cytotoxic and concentration-dependently increased anti-HCoV-NL63 activities, including cytopathicity, sub-G1 fraction, virus yield (IC50 = 1.17 μg/ml), plaque formation (IC50 = 4.67 μg/ml) and virus attachment (IC50 = 15.75 μg/ml). Among the phenolic acid constituents in Sambucus FormosanaNakai extract, caffeic acid, chlorogenic acid and gallic acid sustained the anti-HCoV-NL63 activity that was ranked in the following order of virus yield reduction: caffeic acid (IC 50 = 3.54 μM) > chlorogenic acid (IC 50 = 43.45 μM) > coumaric acid (IC 50 = 71.48 μM). Caffeic acid significantly inhibited the replication of HCoV-NL63 in a cell-type independent manner, and specifically blocked virus attachment (IC 50 = 8.1 μM). Therefore, the results revealed that Sambucus Formosana Nakai stem ethanol extract displayed the strong anti-HCoV-NL63 potential; caffeic acid could be the vital component with anti-HCoV-NL63 activity. The finding could be helpful for developing antivirals against HCoV-NL63.

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Section: Discussionmentioning

confidence: 99%

Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

et al. 2019

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“…[22]. GA has been reported to have antibacterial [23,24], antifungal [25], antioxidant [26], anticancer [27], antiinflammatory [28], antiviral [29] and antimutation properties [30]. Although several studies have revealed that GA exerts antimicrobial effects toward human pathogens, few studies have reported on the antimicrobial action against aquatic pathogens.…”

Section: Mechanisms Of Action Of Asgc and Ga Against V Harveyimentioning

confidence: 99%

Extraction, identification and mechanism of action of antibacterial substances from Galla chinensis against Vibrio harveyi

Guo¹,

Wang²,

Feng³

et al. 2020

Biotechnology & Biotechnological Equipment

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The aim of this study was to investigate the extraction of antibacterial substances from Galla chinensis (ASGC) that act against the aquatic pathogen Vibrio harveyi, to identify the chemical composition and explore the mechanism of action. The optimal extraction process was as follows: anhydrous methanol, liquid/material ratio (mL/g) 26:1, extraction temperature 98 C and extraction time 157 min. The diameter of the inhibition zones (21.31 ± 0.51 mm) under the optimal conditions agreed with the predicted value by experimental rechecking. The yield of ASGC was 39.39% ± 0.69%, and two compounds including gallic acid (GA) and penta-O-galloyl-b-D-glucose (5GG) were identified in ASGC. The minimal inhibitory concentration (MIC) values of ASGC and GA were 0.50 and 0.25 mg/mL, respectively. Meanwhile, 5GG and other chemical constituents did not exert antibacterial activities against V. harveyi (MICs > 1 mg/mL). Further investigation of the mechanisms of action of ASGC and GA against V. harveyi revealed their strong destructive effects on the growth of bacterial cells, the integrity and permeability of the cell membrane, and morphological alterations. The report provides a favorable prospect of GA as a potential control agent against V. harveyi in aquaculture.

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“…Regarding the anti-viral role tea flavonoids have been shown to be strong agent [16]. Report demonstrates that catechin can prevent influenza A (H1N1) virus infection and gallic acid can inhibit influenza virus infection [17]. Last three decades several studies suggested that the regular consumption of green tea decreases influenza infection and some cold symptoms.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Maiti¹,

Banerjee²

2020

Preprint

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SARS CoV-2 or COVID-19 pandemic global-outbreak created the most unstable situation of human health-economy. Last two decades different parts of the word experienced smaller or bigger outbreak related to human-coronaviruses. The spikeglycoproteins of the COVID-19 (similar to SARS-CoV) attach to the angiotensin-converting-enzyme (ACE-2) and transit over a stabilized open-state for the viral-internalization to the host-cells and propagate with great efficacy. Higher rate of mutability makes this virus unpredictable/less-sensitive to the protein/nucleic-acid based-drugs. In this emergent situation, drug-induced destabilization of spike-binding to RBD could be a good strategy. In the current study we demonstrated by Bioinformatics (CASTp: Computed-Atlas-of-Surface-Topography, PyMol: molecular-visualization) and Molecular docking (PatchDock) experiments that tea flavonoids catechin-products mainly EGCG or other like theaflavin gallate demonstrated higher Atomic Contact Energy (ACE), surface area and more amino-acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike-protein. Moreover, out of three distinct binding-sites (I, II and III) of spike core when HCQ binds only with site III (farthest from the nCoV-RBD of ACE2 contact), EGCG and TG bind all three sites. As because site I and II is in closer contact with open state location and viral-host contact area so these drugs might have significant effects. Taking into account the toxicity/side-effects by CQ/HCQ, present drugs may be important. Our laboratory is working on tea flavonoids and other phytochemicals in the protection from toxicity, DNA/mitochondrial damage, inflammation etc. The present data might be helpful for further analysis of flavonoids in this emergent pandemic situation.

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Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid

Cited by 73 publications

References 24 publications

Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

Extraction, identification and mechanism of action of antibacterial substances from Galla chinensis against Vibrio harveyi

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

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