Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

Weng, Jing Ru; Lin, Chen Sheng; Lai, Hsueh Chou; Lin, Yu Ping; Wang, Ching Ying; Tsai, Yi‐Hung; Wu, Kun Chang; Huang, Su; Lin, Cheng Wen

doi:10.1016/j.virusres.2019.197767

Cited by 137 publications

(109 citation statements)

References 35 publications

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“…Moreover, based on historical records of the effect of antiviral herbs on SARS and influenza H1N1, Chinese herbal formulas could be an alternative approach for the prevention of SARS-CoV-2 in a high-risk population [107], if no scientifically based therapeutics are available. It was found that Sambucus formasana Nakai exhibited a strong antiviral effect against human coronavirus NL63 [108].…”

Section: Control and Treatment Of Covid-19 Infectionmentioning

confidence: 99%

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

Helmy

Fawzy

Elaswad

et al. 2020

JCM

583

463

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A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of the outbreak was identified by the WHO as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), producing the disease named coronavirus disease-2019 (COVID-19). The virus is closely related (96.3%) to bat coronavirus RaTG13, based on phylogenetic analysis. Human-to-human transmission has been confirmed even from asymptomatic carriers. The virus has spread to at least 200 countries, and more than 1,700,000 confirmed cases and 111,600 deaths have been recorded, with massive global increases in the number of cases daily. Therefore, the WHO has declared COVID-19 a pandemic. The disease is characterized by fever, dry cough, and chest pain with pneumonia in severe cases. In the beginning, the world public health authorities tried to eradicate the disease in China through quarantine but are now transitioning to prevention strategies worldwide to delay its spread. To date, there are no available vaccines or specific therapeutic drugs to treat the virus. There are many knowledge gaps about the newly emerged SARS-CoV-2, leading to misinformation. Therefore, in this review, we provide recent information about the COVID-19 pandemic. This review also provides insights for the control of pathogenic infections in humans such as SARS-CoV-2 infection and future spillovers.

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Section: Control and Treatment Of Covid-19 Infectionmentioning

confidence: 99%

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

Helmy

Fawzy

Elaswad

et al. 2020

JCM

583

463

View full text Add to dashboard Cite

show abstract

“…In addition, tetrandrine activated the p38MAPK pathway in MRC-5 cells, improving the aforementioned host response. Weng et al (2019) tested the ethanolic extracts of Sambucus formosana (elderberry) stems against the human coronavirus strain HCoV-NL63, finding quite high efficacy (EC 50 of 1.17 ± 0.75 μg/mL) for viral yield reduction. With further investigation of the phenolic composition of the extracts and antiviral assays performed on the main individual phenolic acids present, caffeic acid (Fig.…”

Section: Inhibitors Of Other Human Coronovirusesmentioning

confidence: 99%

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

et al. 2020

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Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B 2 , quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.

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“…Elderberry (Sambucus nigra) is hypothesized to have antiviral properties because of its ability to modulate inflammatory cytokines 42 and has been tested both in vitro [43][44][45][46][47] and in vivo against varying viruses. [48][49][50][51][52] At the time of writing, there are no published studies evaluating the use of elderberry and COVID-19.…”

Section: Elderberrymentioning

confidence: 99%

Myth Busters: Dietary Supplements and COVID-19

2020

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News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). During this pandemic when information quickly evolves in the presence of contradicting messages and misinformation, the role of the pharmacist is essential. Here, we review theoretical mechanisms and evidence related to efficacy and safety of select supplements in the setting of COVID-19, including vitamin C, vitamin D, zinc, elderberry, and silver. Evidence evaluating these supplements in COVID-19 patients is lacking, and providers and patients should not rely on dietary supplements to prevent or treat COVID-19. Rather, reference to evidence-based guidelines should guide treatment decisions.

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Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

Cited by 137 publications

References 35 publications

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Myth Busters: Dietary Supplements and COVID-19

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