Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota

Malaiwong, Nawaphat; Chalorak, Pawanrat; Jattujan, Prapaporn; Manohong, Preeyanuch; Niamnont, Nakorn; Suphamungmee, Worawit; Sobhon, Prasert; Meemon, Krai

doi:10.1016/j.biopha.2018.11.063

Cited by 40 publications

(32 citation statements)

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“…Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders in the elderly population. Dopaminergic (DA) neuron loss and α -synuclein aggregation may lead to PD [ 30 ]. By administration of 6-hydroxydopamine (6-OHDA), a neurotoxic agent, the degeneration of GFP-tagged DA neurons could be observed in C. elegans transgenic mutant strain BZ555 [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…Dopaminergic (DA) neuron loss and α -synuclein aggregation may lead to PD [ 30 ]. By administration of 6-hydroxydopamine (6-OHDA), a neurotoxic agent, the degeneration of GFP-tagged DA neurons could be observed in C. elegans transgenic mutant strain BZ555 [ 30 ]. To identify whether SDG could protect DA neurons from 6-OHDA-induced neurodegeneration, we quantified the fluorescence intensity of neuronal dendrites in the strain BZ555.…”

Section: Resultsmentioning

confidence: 99%

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Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Tan

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed, sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of SDG on health, many are age related, such as anticancer, antidiabetes, antioxidant, and neuroprotective effects. Thus, we investigated if SDG had an effect on antiaging in Caenorhabditis elegans (C. elegans). Our results showed that SDG could extend the lifespan of C. elegans by up to 22.0%, delay age-related decline of body movement, reduce the lethality of heat and oxidative stress, alleviate dopamine neurodegeneration induced by 6-hydroxydopamine (6-OHDA), and decrease the toxicity of Aβ protein in C. elegans. SDG could increase the expression of the downstream genes of DAF-16, DAF-12, NHR-80, and HSF-1 at mRNA level. SDG could not extend the lifespan of mutants from genes daf-16, hsf-1, nhr-80, daf-12, glp-1, eat-2, and aak-2. The above results suggested that SDG might enhance the stress resistance, delay the progression of aging-related diseases, and extend the lifespan of C. elegans via DAF-16 and HSF-1.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Tan

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…A previous study has suggested that H. leucospiota extracts exhibit potential anti‐oxidant activity (Dyck, Gerbaux, & Flammang, ). We recently reported that H. leucospilota extracts exhibit an anti‐Parkinson effect in a C. elegans model of PD (Malaiwong et al, ). Another study from our laboratory also demonstrated that supplementation of H. leucospiota extracts can reduce fat deposition and triglyceride levels of a C. elegans model of obesity (Chumphoochai, Chalorak, Suphamungmee, Sobhon, & Meemon, ).…”

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confidence: 99%

Saponin‐rich extracts fromHolothuria leucospilotamediate lifespan extension and stress resistance inCaenorhabditis elegansviadaf‐16

2019

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Saponins are secondary metabolite compounds that can be found in sea cucumbers (Holothuroidea spp.). However, little is known about how saponin‐rich extracts from Holothuria leucospilota can delay and prolong the lifespan of the whole organism. In this study, anti‐aging effects of H. leucospilota extracts were studied on Caenorhabditis elegans. NMR analysis revealed that body wall n‐butanol‐extract of H. leucospilota (BW‐BU) is saponin‐rich. BW‐BU extracts exhibited antioxidant activities by 2,2ʹ‐diphenyl‐2‐picrylhydrazyl assay (EC50 = 10.23 ± 0.12 mg/ml) and 2,2ʹ‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulphonic acid assay (EC50 = 3.91 ± 0.04 mg/ml). BW‐BU extracts increased lifespan of L4 and L1 C. elegans (5.92% and 15.76%, respectively), which also increased worm growth, stress resistance, and reduced biomarkers for aging. BW‐BU extracts activated DAF‐16 nuclear localization and upregulated daf‐16 and DAF‐16 target genes expression. Taken together, this study revealed the evidences on anti‐aging activities of saponin‐rich extracts from H. leucospilota, which can extend lifespan of C. elegans via daf‐16. Practical applications In recent years, age‐associated chronic diseases have had a significant impact on quality of life. Many natural compounds exhibit anti‐aging activities, especially in sea cucumber, H. leucospilota. Our results indicated that H. leucospilota is good for health. Extracts from H. leucospilota contain a bioactive compound that can be potentially used to promote longevity and disease prevention in aging.

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confidence: 99%

“…of α-synuclein protein, neuronal inflammation, and axonal transport (Malaiwong et al, 2019;Saleem et al, 2019). Neurodegeneration in PD intensifies due to dopaminergic loss and oxidative stress that results from the aggregation of α-synuclein (Lewy body), and mitochondrial dysfunction.…”

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confidence: 99%

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

et al. 2021

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Parkinson's disease (PD), the second most prevalent neurodegenerative disorder presented by impaired motor coordination (muscle rigidity, tremor, postural imbalance, and slowness of movements) and non-motor symptoms (mood disorders, sleep disorders, and cognitive deficit) (Malaiwong et al., 2019). Globally, 10 million individuals are suffering from PD. It affects 2-3% of people more than 65 years of age (Poewe et al., 2017). Neuropathologically, it is attributed to dopaminergic neuronal loss primarily in substantia nigra, accumulation

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Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota

Cited by 40 publications

References 45 publications

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Saponin‐rich extracts fromHolothuria leucospilotamediate lifespan extension and stress resistance inCaenorhabditis elegansviadaf‐16

Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach

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