2021
DOI: 10.1159/000520641
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Anti-Phospholipase A2 Receptor in Nonlupus Patients with Membranous Nephropathy and Crescents

Abstract: Introduction: Anti-phospholipase A2 receptor (PLA2R) is detected in approximately 70% of biopsies of “primary” membranous nephropathy (MN). Crescents in MN in non-lupus patients suggest additional injury, such as antineutrophil cytoplasmic antibody (ANCA) or anti-glomerular basement membrane (anti-GBM)-associated glomerulonephritis and is postulated to reflect injury by a mechanism that unmasks cryptic epitopes leading to the second autoantibody. Methods: We studied PLA2R staining in non-lupus patients with M… Show more

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Cited by 2 publications
(4 citation statements)
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“…Most cases of MN with crescents are not associated with anti-PLA2R antibodies. 5 , 6 , 7 , 8 , 9 In our experience with 4 additional cases of PLA2R-negative MN with anti-GBM disease, none were associated with THSD7A, EXT2, or NELL1.…”
Section: Discussionmentioning
confidence: 67%
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“…Most cases of MN with crescents are not associated with anti-PLA2R antibodies. 5 , 6 , 7 , 8 , 9 In our experience with 4 additional cases of PLA2R-negative MN with anti-GBM disease, none were associated with THSD7A, EXT2, or NELL1.…”
Section: Discussionmentioning
confidence: 67%
“…of biopsies) Pts with kidney failure requiring long-term HD or Tx (%, no. of pts) Jia et al 7 8 32 1F, 7M NA 7.9 NA 5.9 NA 62 (5/8) 1/5 62 (5/8) 37 (3/8) Nikolopoulou et al 5 5 55 3F, 2M 4W, 1A 22.0 2.5 7.6 60 (3/5) 20 (1/5) 0/4 40 (2/5) 60 (3/5) Alawieh et al 6 2 24 1F, 1M 2W 2.8 (1 pt was anuric) 3.6 (NA for 1 pt) 16.8 100 (2/2) 100 (2/2) 0/2 100 (2/2) 100 (2/2) Ahmad et al 8 12 55 5F, 7M 9W, 1B, 2NA 3+ on urinalysis 2.9 9.7 100 (12/12) 8 (1/12) 1/5 83 (10/12) 83 (9/12) Zuo et al 9 2 67 0F, 2M 2W 5.5 (NA for 1 pt) NA 11.4 1 pt did not require HD (NA for 1 pt) NA 0/2 100 (2/2) 1 pt recovered kidney function (NA for 1 pt) Combined data from published case series 29 47 b (18 to 81) 10F, 19M 17W, 1B, 1A, 10NA - - 8.9 b 85 (17/20) 33 (9/27) 11% (2/18) 72 (21/29) 61 (17/28) A, Asi...…”
Section: Discussionmentioning
confidence: 99%
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