Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view

Meroni, Pier Luigi; Tedesco, Francesco; Locati, Massimo; Vecchi, Annunciata; Simone, Nicoletta Di; Acaia, Barbara; Pierangeli, SS; Borghi, Maria Orietta

doi:10.1177/0961203309361351

Cited by 50 publications

(33 citation statements)

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“…Treatment of these patients is based on the use of platelets antiaggregants and anticoagulants aimed to prevent placental thrombotic events that would ultimately lead to miscarriage. Nevertheless, the participation of β2GP1-dependent non-thrombotic events that would be responsible for the defective placentation observed in APS [4][5][6], would lead to reformulation of the treatment currently applied to these patients. It is worth noting that, although the number of patients included in the present study may seem somewhat low, this is due to the fact that we have been very strict as regards the inclusion criteria applied, thus partly explaining the amplitude of the confidence interval obtained.…”

Section: Resultsmentioning

confidence: 99%

“…Although placental thrombotic events may play an important role [3], it is nowadays assumed that non-thrombotic mechanisms would be the main cause for the defective placentation observed in patients with antiphospholipid syndrome (APS) [4][5][6]. APS is an autoimmune disease characterized by arterial/venous thrombosis and/or obstetric complications, associated to the persistent presence of anticardiolipins (ACA) and/or lupus anticoagulant (LA) and/or anti-2 glycoprotein 1(a-2GP1) [7].…”

Section: Introductionmentioning

confidence: 99%

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Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome

et al. 2016

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Ethical approval: The study was approved by the Bioethics Comitee of Facultad de Ciencias Bioquímicas y Farmacéuticas (Universidad Nacional de Rosario). Res Nº 076/2008. All participants signed the corresponding informed consent. Guarantor: SMMA Contributorship: HFP performed most assays and analysis of results, and wrote the paper. EP and CB performed some assays and collaborated in the analysis of results. JM performed patients selection for the study and aided in medical matters. MB, MJS and SMD performed sample collection and conditioning, as well as some laboratory determinations. HB performed statistical analysis. SMMA coordinated and supervised the whole study. Abstract word count: 251. Actual word count (excluding abstract and references): 2664 AbstractBackground: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid (APL) antibodies (Abs). They are directed to phospholipids, such as cardiolipins (a-cardiolipin, ACA) and lupus anticoagulant (LA), or to complexes formed by phospholipids and protein cofactors, such as β2 glycoprotein 1 (a-β2GP1) and annexin V (a-annexin V). These auto Abs may be considered as a family of Abs involved in thrombotic events and APL activity. On the other hand, some proangiogenic factors are involved in the normal development of placental vasculature, such as the vascular endothelial growth factor (VEGF). Overexpression of VEGF receptor in its soluble form (sVEGFR-1) has been associated to a higher antiangiogenic activity. Our aim was to analyze the association between ACA, LA, a-β2GP1, a-annexin V and sVEGFR-1 with recurrent miscarriage before week 10 of gestation in women with APS. Methods: We studied 24 women (primary or secondary APS), who were divided into two groups: women with recurrent miscarriage before week 10 of gestation [M; n=12] and women with no history of fetal loss [NM; n=12]. ACA, a-β2GP1, aannexin V and sVEGF-R1 levels were assessed by ELISA, while LA was assessed by screening and confirmatory tests. Results: A significant association was observed between the number of positive biomarkers and the belonging group (p<0.05). Besides, a positive result for LA and a-β2GP1 was found to be significantly associated to the M group (p<0.05). Conclusions: LA and a-β2GP1 may be implicated in pregnancies complicated by recurrent miscarriage in women with APS.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome

et al. 2016

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“…3596 g), while they found no significant difference between mothers with CD and healthy women in relation to birth weight (3447 g vs. 3596 g) (19). The risk of developing IUGR is fivefold higher in case of fathers with CD than in the general population (11 % vs. 2.5 %) (71,76).…”

Section: Celiac Disease In Relation To Reproductive Failuresmentioning

confidence: 95%

Antibodies and autoimmune diseases in relation to reproductive failures

Kovács¹

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IV. Kovacs M., Hartwig M., Aleksza M., Tihanyi M., Nagy T., Vajda Gy., Daru J., XVII. Bodorkos I., Aleksza M., Horvath E., Dancza T., Farkas A., Gyorkos A., Kovacs M., Tiboly M., Toth P., Gasztonyi B.: Haemotherapy and its serological aspects of patients suffering from immunohaematological diseases. Blood Reviews, Suppl., 21, 119., 2007. IF: 5.922XVIII. Farkas A., Kovacs M., Gyorkos A., Milics M., Nagy Gy., Tarnok F.: Serious clinical manifestations of Systemic lupus erythematosus -case report. Magyar Belorv.

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Section: Introductionmentioning

confidence: 99%

“…Thrombosis at the placental level cannot elucidate all of the clinical manifestations (Meroni et al, 2010). It has been suggested that aPL may be responsible for a local acute inflammatory response mediated by complement activation (Sotoudeh Jahromi, 2007a;Meroni et al, 2010) and neutrophil infiltration eventually leading to fetal loss (Meroni et al, 2010). In addition to the Classical Lupus Anticoagulant (LAC) and AntiCardiolipin Antibodies (ACA), other anti-Phospholipid Antibodies (aPL) were shown to target anionic phospholipids and other plasma proteins, including phosphatidylethanolamine, protein C, protein S, ß 2 -Glycoprotein I (GPI) and annexin V (Tincani et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Anti β<sub>2</sub>-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion

Jahromi¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement: Antiphospholipid antibodies (aPL) are associated with repeated miscarriages and pregnancy complications, however their pathogenic mechanisms are still matter of research. Anti-β 2 glycoprotein 1 (β 2 GPI) antibody is one of these aPL that its contribution to RSA risk remains poorly understood. There were not any data about role this auto-antibody in RSA in South of Iran. This study was conducted to assess Anti-β 2 GPI IgM and IgG as RSA risk factors for RSA in this area of Iran. Approach: This case-control study was carried out in gynecology special hospital of Hormozgan University of medical sciences, during [2004][2005]. A number of 250 women with >3 consecutive idiopathic pregnancy losses as a case group and 200 age matched women with normal full term delivery and negative history of miscarriage as a controls were studied. All obtained sera from the case and the control groups were tested using an Enzyme Linked Immunosorbent Assay (ELISA) method for detection of anti-β 2 GPI IgM and IgG. Data was analyzed, using SAS 8 statistical software (chi square and t-test). Results: There were significant differences between the prevalence of positive anti-β 2 GPI IgM (p = 0.01) and IgG (p = 0.02) in the case group and the control group. A positive significant relationship was observed in the case group between number of abortion and seropositivity for anti-β 2 GPI IgG (p = 0.028, r = +0.181) and anti-β 2 GPI IgM (p = 0.0381, r = +0.014). Conclusion: This study showed anti-ß 2 GPI antibodies are important causative agent for RSA in this area of Iran.

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Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view

Cited by 50 publications

References 14 publications

Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome

Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome

Antibodies and autoimmune diseases in relation to reproductive failures

Anti β<sub>2</sub>-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion

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