Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

“…fresh fruits (unpublished results); it is a bicyclo-[3.3.1]-nonane derivative with only one aliphatic methyl belonging to a bicyclo moiety. GA presents anti-HIV (18), cytotoxic (19), trypanocidal, antiplasmodial (20), and leishmanicidal activities (21). The presence of a planar chelating six-membered cyclic system electronically delocalized and two phenolic hydroxyl groups in the GA structure provide both antioxidant and ironchelating potentials; these potentials, however, have been little explored.…”

In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants

“…This species is known as a rich source of prenylated xanthones and benzophenones. Previously we reported the isolation of antiplasmodial and antioxidant constituents from the seed shell of the plant (Ngouela et al, 2006).…”

Growth curve, biochemical profile and phytochemical analyses in calli obtained from the procambium segments of Bacupari

“…Previous reports have demonstrated the presence of bioactive compounds in this plant, such as biflavonoids and prenylated xanthones and benzophenones (Delle Monache et al 1984;Santos et al 1999). Among the natural bioactive compounds, the polyisoprenylated benzophenones are associated with the biological activities such as anti-HIV (Gustafon et al 1992); leishmanicidal (Pereira et al 2010), free radical scavenger (Ngouela et al 2006), anti-cholinesterase (Lenta et al 2007), anti-inflammatory and antinociceptive (Santa-Cecília et al 2011). Three natural polyisoprenylated benzophenones have been isolated from Garcinia brasiliensis: Guttiferone-A (Gustafson et al 1992), 7-epiclusianone (Santos et al 1999) and Garciniaphenone (Derogis et al 2008).…”