2015
DOI: 10.7314/apjcp.2015.16.14.6039
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Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model

Abstract: Aims: To investigate effect of metallic nanoparticles, silver (AgNPs) and gold nanoparticles (AuNPs) as antitumor treatment in vitro against human breast cancer cells (MCF-7) and their associated mechanisms. This could provide new class of engineered nanoparticles with desired physicochemical properties and may present newer approaches for therapeutic modalities to breast cancer in women. Materials and Methods: A human breast cancer cell line (MCF-7) was used as a model of cells. Metallic nanoparticles were ch… Show more

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Cited by 47 publications
(32 citation statements)
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“…Therapeutic options in advanced irresectable HCC are limited to sorafenib, which is the available conventional chemotherapy for HCC treatment. However, the acquired resistance to sorafenib, in addition to its severe side effects and toxicity, limits its beneficial effects (Loutfy et al, 2015;Abdel Hamid et al, 2018;Raoul et al, 2018). Therefore, the current study aimed at minimizing the toxic effects of sorafenib through investigating additive or synergistic potential of photothermal therapy (PTT) by using laser-irradiated gold nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…Therapeutic options in advanced irresectable HCC are limited to sorafenib, which is the available conventional chemotherapy for HCC treatment. However, the acquired resistance to sorafenib, in addition to its severe side effects and toxicity, limits its beneficial effects (Loutfy et al, 2015;Abdel Hamid et al, 2018;Raoul et al, 2018). Therefore, the current study aimed at minimizing the toxic effects of sorafenib through investigating additive or synergistic potential of photothermal therapy (PTT) by using laser-irradiated gold nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…The cytotoxicity of the JB against B16F10 cells was tested by Sulforhodamine B (SRB) assay27. In brief, B16F10 cells were collected after digestion with 0.05% Trypsin-EDTA and cultured in 96-well microplates (1 × 10 5  cells/mL, 100 μL).…”
Section: Methodsmentioning
confidence: 99%
“…This result is reasonable and can be explained in two ways. The first is that metal nanoparticles has been proved to be possess a cytotoxic activity thus can act synergistically with anti-cancer agents [18,19]. Secondly folic acid on FA-AuNp-Rsv conjugate can act as a helper that increase the amount of conjugate presence on the MCF-7 cells surface through binding with folate receptors and by that maximize the drugs that enter the cells.…”
Section: Cytotoxicity Testmentioning
confidence: 99%