Anti-Proliferative Effect of  Specific Anti-EGFR Single Chain Antibody on  Triple Negative Breast Cancer Cells

Abdollahzadeh, Forough; Nejatollahi, Foroogh

doi:10.29252/rbmb.9.2.180

Cited by 4 publications

(3 citation statements)

References 43 publications

(37 reference statements)

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“…As a membrane-associated glycoprotein, CD90 is considered as a potential stem cell biomarker. , Tissue sections were treated by immunohistochemical staining (CD90) (Figure a), and positive immunohistochemical staining of CD90 was counted in ten randomly selected fields of view at the edge of the air pouch (Figure b). The results showed that UHMWPE had no significant recruitment effect on stem cells compared to control, while compared with CPP, a higher number of CD90-positive cells near the air pouch stimulated by ECPP particles was found, suggesting that the release of Eu ions could promote the recruitment of stem cells.…”

Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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Modulating both inflammation and stem cells by designing an artificial joint material to obtain the continuous prevention and control on aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound method and spark plasma sintering (SPS) method. The prepared particles were used to modulate the inflammatory response and further obtain cascade regulation on the proliferation, recruitment, and differentiation of stem cells. The results showed that particles obtained by SPS had a stronger effect on promoting the proliferation and differentiation of stem cells, while by ultrasound method more stem cells were recruited. Besides, the graphene and Eu3+ contained in the particles obtained by SPS method could effectively play a synergistic role on the differentiation of stem cells. In vivo experiment results demonstrated that the composite particles effectively suppress the inflammatory response, recruit stem cells, and prevent AL by inhibiting the secretion of inflammatory factors.

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Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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“…EGFR is a protein that is often overexpressed on cancer cells. Anti-EGFR antibodies can be used to target NDEs to cancer cells, or they can be used to deliver drugs or other therapeutics to cancer cells [145]. PD-1 (Programmed cell death protein 1) is expressed by T Cells and helps to regulate the immune response.…”

Section: Ndes As Therapeutic Tools In Cancermentioning

confidence: 99%

Neutrophils in Cancer and Potential Therapeutic Strategies using Neutrophil-derived Exosomes

Dutta¹,

Bhagat²,

Paul³

et al. 2023

Preprint

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Neutrophils are the most abundant immune cells and make up about 70% of white blood cells in human blood and play a critical role as the first line of defense in the innate immune response. They also help regulate the inflammatory environment to promote tissue repair. However, in cancer, neutrophils can be manipulated by tumors to either promote or hinder tumor growth depending on the cytokine pool. Studies have shown that tumor-bearing mice have increased levels of neutrophils in peripheral circulation, and that neutrophil-derived exosomes can deliver various cargos, including lncRNA and miRNA, which contribute to tumor growth and degradation of extracellular matrix. Exosomes derived from immune cells generally possess anti-tumor activities and induce tumor-cell apoptosis by delivering cytotoxic proteins, ROS generation, H2O2 or activation of Fas-mediated apoptosis in target cells. Engineered exosome-like nanovesicles have been developed to deliver chemotherapeutic drugs precisely to tumor cells. However, tumor-derived exosomes can aggravate cancer-associated thrombosis through the formation of neutrophil extracellular traps. Despite the advancements in neutrophil-related research, a detailed understanding of tumor-neutrophil crosstalk is still lacking and remains a major barrier in developing neutrophil-based or targeted therapy. This review will focus on the communication pathways between tumors and neutrophils, and the role of neutrophil-derived exosomes (NDEs) in tumor growth. Additionally, potential strategies to manipulate NDEs for therapeutic purposes will be discussed.

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“…EGFR is a protein that is often overexpressed in cancer cells. Anti-EGFR antibodies can be used to target NDEs to cancer cells, or they can be used to deliver drugs or other therapeutics to cancer cells [ 166 ]. PD-1 (Programmed cell death protein 1) is expressed by T Cells and helps to regulate the immune response.…”

Section: Ndes As Therapeutic Tools In Cancermentioning

confidence: 99%

Neutrophils in Cancer and Potential Therapeutic Strategies Using Neutrophil-Derived Exosomes

et al. 2023

View full text Add to dashboard Cite

Neutrophils are the most abundant immune cells and make up about 70% of white blood cells in human blood and play a critical role as the first line of defense in the innate immune response. They also help regulate the inflammatory environment to promote tissue repair. However, in cancer, neutrophils can be manipulated by tumors to either promote or hinder tumor growth depending on the cytokine pool. Studies have shown that tumor-bearing mice have increased levels of neutrophils in peripheral circulation and that neutrophil-derived exosomes can deliver various cargos, including lncRNA and miRNA, which contribute to tumor growth and degradation of extracellular matrix. Exosomes derived from immune cells generally possess anti-tumor activities and induce tumor-cell apoptosis by delivering cytotoxic proteins, ROS generation, H2O2 or activation of Fas-mediated apoptosis in target cells. Engineered exosome-like nanovesicles have been developed to deliver chemotherapeutic drugs precisely to tumor cells. However, tumor-derived exosomes can aggravate cancer-associated thrombosis through the formation of neutrophil extracellular traps. Despite the advancements in neutrophil-related research, a detailed understanding of tumor-neutrophil crosstalk is still lacking and remains a major barrier in developing neutrophil-based or targeted therapy. This review will focus on the communication pathways between tumors and neutrophils, and the role of neutrophil-derived exosomes (NDEs) in tumor growth. Additionally, potential strategies to manipulate NDEs for therapeutic purposes will be discussed.

show abstract

Anti-Proliferative Effect of Specific Anti-EGFR Single Chain Antibody on Triple Negative Breast Cancer Cells

Cited by 4 publications

References 43 publications

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Neutrophils in Cancer and Potential Therapeutic Strategies using Neutrophil-derived Exosomes

Neutrophils in Cancer and Potential Therapeutic Strategies Using Neutrophil-Derived Exosomes

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