Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight

Salakhieva, Diana V.; Gumerova, D. R.; Akhmadishina, Rezeda A.; Kamalov, Marat I.; Nizamov, I. S.; Németh, Csaba; Szilágyi, András; Abdullin, Timur I.

doi:10.1007/s12668-016-0230-0

Cited by 10 publications

(19 citation statements)

References 11 publications

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Section: Biocompatibility Of Pasp and Its Derivativesmentioning

confidence: 99%

“…in various studies and attributed to their protein-like backbone structure [116][117][118] . In vitro studies showed PASP non-toxicity to 3T3 fibroblasts as well as PC-3 cells (prostate cancer cell) with IC50 > 3 mg/mL 116 . PASP-based hydrogels were efficiently utilised as scaffolds for cultivation of osteoblasts (MG-63), further verifying PASP biocompatibility 113 .…”

Section: Biocompatibility Of Pasp and Its Derivativesmentioning

confidence: 99%

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Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Adelnia

Tran

Little

et al. 2021

ACS Biomater. Sci. Eng.

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Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has been exploited for bone targeting and biomineralization. In addition, recent studies have further verified the biocompatibility and biodegradability of PASP-based polymers, which is attributed to their protein-like structure. In light of growing interest in PASP and its derivatives, this paper presents a comprehensive review on their synthesis, characterization, modification, biodegradation, biocompatibility, and applications in biomedical areas.

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Section: Biocompatibility Of Pasp and Its Derivativesmentioning

confidence: 99%

Section: Biocompatibility Of Pasp and Its Derivativesmentioning

confidence: 99%

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Adelnia

Tran

Little

et al. 2021

ACS Biomater. Sci. Eng.

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“…Polyaspartic acid (PASP) has excellent properties, such as being non‐polluting and fully biodegradable, and having good chelating ability, high dispersibility, and pH‐responsive characteristics. As an organic and green polymer material, PASP has presented broad prospects on scale inhibition, corrosion mitigation, moisture‐holding capacity, and materials manufacture for biomedical application as well as architectural decoration in past decades 13‐17 . In recent years, PASP has been used as a fertilizer synergist in a few crop systems covering cereals, 18,19 oil plants, 20 vegetables, 21,22 herbs, 23,24 fruits, 25 and trees, 26 and has been attracting intense public interest.…”

Section: Introductionmentioning

confidence: 99%

“…As an organic and green polymer material, PASP has presented broad prospects on scale inhibition, corrosion mitigation, moisture-holding capacity, and materials manufacture for biomedical application as well as architectural decoration in past decades. [13][14][15][16][17] In recent years, PASP has been used as a fertilizer synergist in a few crop systems covering cereals, 18,19 oil plants, 20 vegetables, 21,22 herbs, 23,24 fruits, 25 and trees, 26 and has been attracting intense public interest. In general, molecular chains of PASP have basic Lewis groups (amidogen and carboxyl) that can combine with cations (including NH 4 + ) to form water-soluble complexes.…”

Section: Introductionmentioning

confidence: 99%

Effects of molecular weight of polyaspartic acid on nitrogen use efficiency and crop yield

et al. 2022

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Background: In the past decades, ever-increasing fertilizer use has led to a continuous increase in agricultural output. However, serious waste of resources occurs because of the low utilization of fertilizers. Polyaspartic acid (PASP) is a biodegradable polymer that can be used as a fertilizer synergist in agricultural production to improve the nutrient utilization capacity of plants. For polymers, the molecular weight (MW) often affects their effectiveness. However, little information is available on the effects of PASP MW in agriculture, especially on nitrogen leaching and plant element uptake.Results: This work was conducted to identify the effect of PASPs with three different MWs -PASP-1 (MW: 5517), PASP-2 (MW: 6934), and PASP-3 (MW: 7568)on nitrogen leaching, lettuce growth, and wheat cultivation. The results revealed that PASP favored plant growth and nitrogen accumulation in the soil, independent of crop species. PASP with a higher MW improved yields and the agronomic characteristics of lettuce and wheat. Furthermore, apparent amelioration of nitrogen use efficiency for lettuce (7.6%, 12.8%, and 15.0%) and wheat (4.6%, 8.1%, and 9.2%) was observed in the treatments with PASP addition. The effects and merits of PASPs on preventing ammonium nitrogen leaching and improving lettuce and wheat productivity were as follows: PASP-3 > PASP-2 > PASP-1. Conclusion:The MW of PASP is an essential factor affecting inorganic nitrogen leaching and crop productivity, and PASP with a higher MW ( 7568) is recommended for application in agriculture.

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“…PASP is usually modified with diamines, poly(ethylene glycol) (PEG)-diepoxide or aminothiols like cysteamine that can be crosslinked, resulting in PASP-based hydrogels and SAPs [27]. Hydrogels and SAPs based on PASP have been reported in a plethora of applications, especially in the biomedical field as a result of their biocompatibility [28], e.g. scaffolds for tissue engineering [29][30][31], coatings to prevent biofouling [32], carriers for DNA and RNA transfection [33][34][35][36], 'smart' hydrogels for controlled drug release [37][38][39][40][41], etc.…”

mentioning

confidence: 99%

Poly(aspartic acid) superabsorbent polymers as biobased and biodegradable additives for self-sealing of cementitious mortar

Grave

Filho

Snoeck

et al. 2022

Journal of Sustainable Cement-Based Materials

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Lauren De Grave: Lauren De Grave started a Bachelor in Chemistry at Hasselt University (Belgium) in 2013, after which she continued to a Master at KU Leuven (Belgium). In 2018, she obtained her Master's degree in Chemistry with specialization in organic synthesis after completing a Master's thesis in the group of Prof. Dr. Wim Dehaen. After graduating, she started working as a researcher at KU Leuven in the research group of Prof. Dr. Mario Smet. This research focused on the development and optimization of several organic compounds (monomers, polymers, dispersants and additives) as organic matrix for the preparation of ceramic slurries with beneficial properties for 3D printing of dental prostheses. Since 2020, she is working as a joint PhD student in Ghent University (Polymer Chemistry & Biomaterials Group, Belgium) and Maastricht University (Aachen-Maastricht Institute for Biobased Materials, The Netherlands) under the supervision of Prof. Dr. Sandra Van Vlierberghe and Prof. Dr. Katrien Bernaerts. She is currently working on the Interreg project GREENER, which focuses on the development of a biobased and biodegradable alternative for the water-soluble and wide-spread polyacrylic acid.

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Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight

Cited by 10 publications

References 11 publications

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Effects of molecular weight of polyaspartic acid on nitrogen use efficiency and crop yield

Poly(aspartic acid) superabsorbent polymers as biobased and biodegradable additives for self-sealing of cementitious mortar

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