Anti-Saccharomyces cerevisiae (ASCA) and anti-endomysial antibodies in spondyloarthritis

Andretta, Marianne A.; Vieira, Thaís de Oliveira; Nishiara, Renato; Skare, Thelma Larocca

doi:10.1007/s00296-010-1722-9

Cited by 18 publications

(4 citation statements)

References 12 publications

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“…Several recent studies have shed light on the spectrum of noninflammatory bowel diseases demonstrating ASCA phenomenon (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). ASCA do precede Crohn's disease development in as many as one-third of individuals, but the positive predictive value of the test becomes of relevant issue and clinicians using ASCA in the evaluation of inflammatory bowel disease should be aware of this (32).…”

Section: Discussionmentioning

confidence: 99%

“…It has also been shown that ASCA had a highpredictive value for inflammatory bowel disease (4). Additionally, elevated levels of ASCA had also been found in patients with Behcet's disease (5), spondyloarthritis (6), celiac disease (CD) (7,8), intestinal tuberculosis (9), primary biliary cirrhosis (10,11), autoimmune hepatitis (12), type 1 diabetes (13), and systemic lupus erythematosus (14,15).…”

Section: Introductionmentioning

confidence: 96%

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Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis

Mankaï¹,

Thabet²,

Manoubi³

et al. 2012

Endocrine Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis

Mankaï¹,

Thabet²,

Manoubi³

et al. 2012

Endocrine Research

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“…The development of arthritis in these patients probably involves genetic and environmental components, which turn patients susceptible to luminal microbiota that triggers the arthritis [8]. In our region, Andretta et al [23] studying 70 patients with SpA described an increase of the IgA-ASCA (anti- Saccharomyces cerevisiae antibody) positivity, suggesting that this group could have a greater intestinal permeability. However, these authors could not demonstrate any relationship of IgA ASCA with disease activity, functional index or clinical profile.…”

Section: Discussionmentioning

confidence: 99%

Anti-CCP Antibodies and Rheumatological Findings in Brazilian Patients with Crohn's Disease

et al. 2015

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Background/Aims: Arthropathy is the most common extraintestinal manifestation observed in patients with Crohn's disease (CD). The present study aimed to screen rheumatoid arthritis (RA) using anti-CCP antibodies and rheumatoid factor (RF) in CD patients from Southern Brazil. Additionally, the presence of arthralgia and spondyloarthritis (SpA) was evaluated. CD patients, previously diagnosed using clinical data, imaging tests, endoscopic and histological findings, were included consecutively. Methods: A total of 100 patients participated in the study, of which 60% were female, with a mean age of 41.9 ± 12.04 (16-83 years). As controls, sera from 100 healthy individuals from the same geographic area were analyzed. Results: Arthralgias were present in 55% of the patients, being more frequent in women (65.5%; 36/55), than in males (34.5%). No association was found between arthralgia and the treatment method used. Six patients (6/100) had SpA previously diagnosed. In the CD group, anti-CCP was positive only in one patient, while RF was positive in 7 patients (7%; 7/100). The anti-CCP positive patient (woman, 38 years old, RF positive), fulfilled the ACR criteria and was diagnosed as RA. In the control group, anti-CCP antibodies were detected in 1% (1/100) and RF was positive in 6 of the samples (6%). Conclusion: Our data showed low frequency of anti-CCP antibodies and RF in Brazilian patients with CD. Additionally, we found a high prevalence of arthralgia in these patients, with 6% of them diagnosed with SpA.

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“…They also demonstrated that intestinal IL-23 plays a pivotal role in the pathogenesis of β-glucan-induced SpA pathogenesis in SKG mice [12] . In humans, anti-Saccharomyces cerevisiae antibodies (ASCAs) are detected in Crohn's disease patients and in AS patients [13][14][15]. The importance of the IL-23-IL-17 axis has been emphasised also in human SpA pathogenesis [16].…”

Section: Introductionmentioning

confidence: 99%

Oral Dextran Sulfate Sodium Administration Induces Peripheral Spondyloarthritis Features in SKG Mice Accompanied by Intestinal Bacterial Translocation and Systemic Th1 and Th17 Cell Activation.

Tabuchi¹,

Katsushima²,

Y³

et al. 2021

Preprint

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Background: Spondyloarthritis (SpA) is an autoimmune and autoinflammatory musculoskeletal disease characterised by systemic enthesitis. Recent research has focused on subclinical inflammatory bowel disease (IBD) in SpA pathogenesis. SKG mice, harbouring the Zap70 W163C mutation, increase autoreactive Th17 cells intrinsically, and show SpA features, including enteritis, after peritoneal injection of β-1,3- glucan under SPF conditions. In a conventional environment, they exhibit spontaneous arthritis with fungal factors. This study aimed to clarify whether oral dextran sulfate sodium (DSS) administration, utilised in IBD model mice, can provoke SpA features in SKG mice under SPF conditions, focusing on the relationship between gut microorganisms and SpA pathogenesis.Methods: SKG and BALB/c mice were administered oral DSS, and their body weights, arthritis, and enthesitis scores were recorded. In another cohorts, antibiotics (meropenem and vancomycin) or an anti-fungal agent (amphotericin B) were administered orally before DSS administration. The splenic Th1 and Th17 cell populations were examined before and after DSS administration using flow cytometry. Furthermore, the amount of circulating bacterial DNA in whole blood was measured by absolute quantitative polymerase chain reaction (qPCR), and the number and characteristics of bacterial species corresponding to these circulating DNA were analised by next-generation sequencing (NGS).Results: Ankle enthesitis as a peripheral SpA feature was elicited in half of DSS-administered SKG mice, and none of the BALB/c mice. Pre-administration of antibiotics suppressed enthesitis, whilst an anti-fungal agent could not. Th1 and Th17 cell levels in the spleen increased after DSS administration, and this was suppressed by pre-administration of antibiotics. SKG mice have a larger amount of bacterial DNA in whole blood than BALB/c mice before and one day after the initiation of DSS administration. The number of bacterial species in whole blood increased after DSS administration in SKG and BALB/c mice. Some genera and species significantly specific to the DSS-treated SKG mice group were also detected. Conclusion: Oral DSS administration alone elicited peripheral enthesitis in SKG mice with bacterial translocation accompanied by increased splenic Th1 and Th17 cell levels. Pre-administration of antibiotics ameliorated these DSS-induced SpA features. These findings suggest that intestinal bacterial leakage plays a pivotal role in SpA pathogenesis.

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Anti-Saccharomyces cerevisiae (ASCA) and anti-endomysial antibodies in spondyloarthritis

Cited by 18 publications

References 12 publications

Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis

Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis

Anti-CCP Antibodies and Rheumatological Findings in Brazilian Patients with Crohn's Disease

Oral Dextran Sulfate Sodium Administration Induces Peripheral Spondyloarthritis Features in SKG Mice Accompanied by Intestinal Bacterial Translocation and Systemic Th1 and Th17 Cell Activation.

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