Anti‐Sandwich Structured Photo‐Electronic Wound Dressing for Highly Efficient Bacterial Infection Therapy

Abstract

Photo‐electronic devices based on reactive oxygen species (ROS) generation suffer a crucial limitation in wound treatment due to their sandwich structure, which prevents the contact of ROS with wound tissue. In this work, the first anti‐sandwich structured visible‐light/electricity dual‐responsive wound dressing is constructed for treatment of methicillin‐resistant Staphylococcus aureus (MRSA), based on selenoviologen‐appendant polythiophene (SeV2+‐PT)‐containing polyacrylamide hydrogels. The new wound dressing is named an anti‐sandwich structured photo‐electronic wound dressing (PEWD). The unique structure of PEWD enables its use in synergistic electrodynamic and photodynamic therapy (EDT and PDT), providing rapid, on‐demand, and sustained generation of ROS in situ via short‐time light irradiation and/or wireless‐controlled electrification. The PEWD possesses good flexibility, excellent biocompatibility, and fast response, as well as sustained ROS generation in a physiological environment. Animal experiments demonstrate effective ROS generation in 6 s under irradiation and electrification, inhibiting infection at an early stage, and substantially shortening the healing time of bacterial infection (to within 7 days). This proof‐of‐concept research holds great promise in developing new flexible PEWD, and novel strategies to improve wound treatment.

Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy

“…These results are consistent with the viologen-based PS systems containing main-group elements. 42 The negligible cytotoxicity of nTPy-Rs for healthy cells indicates good biocompatibility and a promising potential to be used as PSs in antimicrobial photodynamic therapy in vivo.…”

“…[31][32][33][34][35][36][37] Profiting from their structural variability, low cost, and adjustable performance, conjugated molecules have been proven to meet the primary requirements of ideal PSs. [38][39][40][41][42] However, it is difficult for the hydrophobic conjugated backbone to bind bacteria and deliver ROS to kill the bacteria. [43][44][45] The introduction of cationic groups, such as quaternary ammonium (-QA) groups, into the side chain provides the possibility for conjugated molecules to bind to bacteria based on electrostatic interaction, which improves the delivery efficiency of ROS.…”

Hydrogel Combined with Phototherapy in Wound Healing

“…Natural network hydrogels used in PTT have the same advantages as PDT (high biocompatibility, good degradation Poly(acrylamide) SeV 2+ -PT Unique structure allows it to be used in collaboration with EDT and PDT [50] Gelatin (GT) and recombinant human collagen III protein (rhCol III)…”

Single Cell Imaging of Electrochemiluminescence‐Driven Photodynamic Therapy

“…Similar to electrochemical therapy (EChT) [23] and electrodynamic therapy (EDT), [24] clinical ECL-PDT may be achieved by inserting electrodes directly into tumors. Less invasive electrodes or self-powered nano-electric generators [25] are also highly anticipated. Combining ECL imaging with the ECL-PDT, the novel strategy not only contributes to a better understanding of dynamic cell pyroptosis process on the single cell level, but also provides promising opportunities of developing ECL-therapy in vitro and in vivo.…”