Anti-SARS-CoV-2 Activity of Polysaccharides Extracted from Halymenia floresii and Solieria chordalis (Rhodophyta)

Jousselin, Clément; Pliego-Cortés, Hugo; Damour, Alexia; Garcia, Magali; Bodet, Charles; Robledo, Daniel; Bourgougnon, Nathalie; Lévêque, Nicolas

doi:10.3390/md21060348

Cited by 4 publications

(1 citation statement)

References 45 publications

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“… 47 , 48 The impact of algal polysaccharides, including carrageenan, on SARS-CoV-2 infection has been investigated, including in clinical trials. 49 – 51 Treatment with the sulfated polysaccharides appears to provide a barrier to impair viral uptake and thereby reduce intracellular viral proliferation. 52 Interestingly, in 8-week-old C57BL/6J male mice exposed to oral carrageenan in their diet for 60 d, lung tissue showed significant increases in phospho-p38 MAPK (Fig.…”

Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

Bhattacharyya,

Tobacman

2024

Sig Transduct Target Ther

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Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB). To explain these findings, human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain (SPRBD) and transcriptional mechanisms were investigated. Phospho-p38 MAPK and phospho-SMAD3 increased following exposure to the SPRBD, and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11, which contributed to chondroitin sulfate biosynthesis. Decline in ARSB was mediated by phospho-38 MAPK-induced N-terminal Rb phosphorylation and an associated increase in Rb-E2F1 binding and decline in E2F1 binding to the ARSB promoter. The increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPK inhibitors, SMAD3 (SIS3) inhibitors, as well as antihistamine desloratadine and antibiotic monensin. In the mouse model of carrageenan-induced systemic inflammation, increases in phospho-p38 MAPK and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ARSB expression occurred in the lung, similar to the observed effects in this SPRBD model of COVID-19 infection. Since accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage, increased attention to p38-MAPK inhibition may be beneficial in ameliorating Covid-19 infections.

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Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

Bhattacharyya,

Tobacman

2024

Sig Transduct Target Ther

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Nanotechnology-driven improvisation of red algae-derived carrageenan for industrial and bio-medical applications

James,

Verma,

Sharma

2023

World J Microbiol Biotechnol

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Relationship between the extraction methods, structural characteristics, and biological activities of polysaccharides from 5 typical polyporaceae fungi

Xu,

Wei,

Zhang

et al. 2024

Guidelines and Standards of Chinese Medicine

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Polyporaceae fungi are widely found in nature and have long been an important part of the field of traditional Chinese medicine field. The numerous health benefits of polyporaceae fungi may be related to their polysaccharides, which have significant biological activities in terms of anti-tumor, immunomodulation, antioxidation, liver protection, and blood lipid-lowering effects. Studies have shown that different extraction methods have a significant impact on the structural characteristics and biological activity of polysaccharides. The structural characteristics of fungal polysaccharides, such as composition, molecular weight, branching degree and glycosidic bond type, are closely related to their biological activity. This article was systematically reviewed the relationship between the extraction and purification methods, structural characteristics, and biological activities of five typical fungal polysaccharides, aiming to provide a scientific basis for the application of polypore fungal polysaccharides in the field of traditional Chinese medicine and lay the foundation for their further research and development.

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Anti-SARS-CoV-2 Activity of Polysaccharides Extracted from Halymenia floresii and Solieria chordalis (Rhodophyta)

Cited by 4 publications

References 45 publications

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

Nanotechnology-driven improvisation of red algae-derived carrageenan for industrial and bio-medical applications

Relationship between the extraction methods, structural characteristics, and biological activities of polysaccharides from 5 typical polyporaceae fungi

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