Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways

Anticonvulsant effects of ivermectin on pentylenetetrazole- and maximal electroshock-induced seizures in mice: the role of GABAergic system and KATP channels

“…), which in our previous studies considered as an ineffective dose, were injected 5 min before IVM (0.2 mg/kg) and 35 min before PTZ infusion. Time intervals and dose selections was based on our previous studies [ 51 , 52 , 53 ].…”

“…15 minutes before diazepam (0.02 mg/kg) and 20 min before IVM (0.2 mg/kg). The mentioned dose and time intervals were based on our previous studies [ 51 , 53 , 54 ].…”

Pharmacotherapeutic potential of walnut (Juglans spp.) in age-related neurological disorders

“…Their results also demonstrated that walnut peptides exert their anti-seizure properties through the modulation of benzodiazepine receptors. Thus, walnut peptides may be considered a new anti-convulsion agent, which can reduce seizure occurrence and slow down seizure progression ( Jahanbani et al, 2021 ).…”

“… Ji Liu Liu et al, (2019a) 2019 In vivo Oxidative stress – Walnut seed coat Walnut seed 100 (WSC) mg/kg/day 600 (WS) mg/kg/day 8 weeks Increasing the AST and ALT levels Shuguang Wang ( Wang et al, 2021 ) 2021 In vivo Oxidative stress Juglans regia WPH 333, 666 mg/ kg/ day 21 days Increase of Level of ACH and ACHR Increase of many mRNA expression such as Nrf2, BDNF, and CREB Shuguang Wang Wang et al, (2020) 2020 In vivo Oxidative stress Juglans regia WPH 666 mg/kg and 400 mg/kg 21 days Reduction of production of NO Normalization of overproduction of pro-inflammatory cytokines such as IL-6, IL-1β and TNF-α Increase of the activity of SOD and CAT Decrease of lipid peroxidation in brain Dayong Ren Ren et al, (2018) 2018 In vivo Oxidative stress Juglans mandshurica Maxim. MWHP 200, 400, 800 mg/kg/day 30 days Inhibiting the reduction of ACh content and ChAT activity caused by scopolamine inhibiting the H2O2-induced cell injury Jahanbani, Raheleh ( Jahanbani et al, 2021 ) 2021 In vivo Anti-seizure effects Juglans regia L. 5, 10, 20, 50, 100 mg/kg walnut peptide A month Modulation of benzodiazepine receptors …”

Bioactive peptides from nuts: A review

“…In this study, the highest degree hydrolysis was obtained with alcalase enzyme (~20) and this value was, in turn, directly related to the highest inhibition of hyaluronidase activity. Besides, Jahanbani et al ., (2021) demonstrated that the intraperitoneal administration of walnut protein hydrolysates to mice 60 min before seizure induction was able to exert anti‐seizure effects through the modulation of gamma‐aminobutyric acid type A (GABAA) receptors.…”