Anti-staphylococcal Effect of a Nephrite-containing Contact Lens Storage Case

Park, Su Hwan; Lee, Seung Uk; Kim, Yoon Kyung; Yu, Hak Sun; Park, Sung Hee; Ahn, Jung Hyo; Kim, Su Jin; Shin, Jong Hoon; Lee, Ji Eun

doi:10.3341/jkos.2020.61.8.868

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…Since nephrite itself has antibacterial activity against Gram-negative or Gram-positive bacteria, nephrite was selected as an antibacterial material for SCL [ 13 , 14 , 15 ]. Additionally, PDA was coated onto the surface of nephrite to emphasize antibacterial activity because it is frequently employed as an antibacterial coating material for various implants [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nephrite is a mineral tremolite or actinolite which is composed of calcium, magnesium and iron. In particular, we previously reported the antibacterial activity of nephrite against Gram-positive or Gram-negative bacteria [ 13 , 14 , 15 ]. We reported that the storage case for nephrite-containing contact lenses showed an inhibitory effect on the proliferation of S. aureus and thus nephrite can be used as a novel antibacterial material for keratitis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, we previously reported the antibacterial activity of nephrite against Gram-positive or Gram-negative bacteria [ 13 , 14 , 15 ]. We reported that the storage case for nephrite-containing contact lenses showed an inhibitory effect on the proliferation of S. aureus and thus nephrite can be used as a novel antibacterial material for keratitis [ 13 ]. They also showed antibacterial activity against pseudomonas aeruginosa ( P. aeruginosa ) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens

Kang

Moon²,

Lee

et al. 2022

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The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.

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