Anti-thrombotic action of sulfated polysaccharides on thrombosis caused by thromboplastin

Increasing amount of evidence suggests that age-related dysregulation of neuronal Ca2+ homeostasis may play a proximal role in the pathogenesis of Alzheimer's disease, as impaired Ca2+ can cause synaptic deficits and contribute to the accumulation of Aβ plaques and neurofibrillary tangles.Ca2+ disruption is known to be mostly involved in all pathologies of Alzheimer's disease, the use of chemical agents or small molecules specific for Ca2+ channels, or the treatment of proteins on the plasma membrane and intracellular organelle membranes for correction is quite possible. Neuronal dysregulation of Ca2+ may open up a new approach to the prevention and treatment of Alzheimer's disease. The article shows the possible competition between the polyphenols PС-6, PС-7 and glutamate for the area of regulation of the opening of ion channels of ionotropic NMDA-receptors in the brain of rats.

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Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate

Khoshimov

Mukhtorov

Nasirov

et al. 2023

RJPT

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Anti-thrombotic action of sulfated polysaccharides on thrombosis caused by thromboplastin

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References 13 publications

Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate

Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate

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