Anti-thrombotic and anti-tumor effect of water extract of caulis of &lt;i&gt;Sargentodoxa cuneata&lt;/i&gt; (Oliv) Rehd et Wils (Lardizabalaceae) in animal models

Daxueteng, the liana stem of Sargentodoxa cuneata, is a widely used Traditional Chinese Medicine facing the overflow of its commercial adulterants. A method for discriminating adulterants and screening potential candidate alternatives of S. cuneata was thus established. Total phenols and flavonoids of S. cuneata and its six adulterants and their abilities to scavenge DPPH• and ABTS•+, to absorb peroxyl radicals (ORAC), and to inhibit AAPH-induced supercoiled plasmid DNA strand scission were comprehensively assessed. Polygonum cuspidatum and Bauhinia championii, two of the six adulterants of S. cuneate, shared considerably higher antioxidant activities as well as phenolic contents and, therefore, were considered as potential candidate alternatives. Phenolic compositions of the two potential candidate alternatives and S. cuneata itself were further determined by UPLC-QTOF-MS/MS. Totally 38 phenolics, including four hydroxybenzoic acids, two tyrosols, two caffeoylquinic acids, seven flavanol or its oligomers, two lignans, three hydroxycinnamic acids, six stilbenes, seven anthraquinones, and five flavanones were determined from three species. Furthermore, contents of different phenolic categories were semi-quantified and the major antioxidant contributors of S. cuneata and the two potential candidate alternatives were subsequently determined. It is concluded that tyrosols and caffeoylquinic acids were unique categories making great antioxidant contributions in S. cuneata and thus were considered as effective biomarkers in distinguishing its potential candidate alternatives.

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Anti-thrombotic and anti-tumor effect of water extract of caulis of <i>Sargentodoxa cuneata</i> (Oliv) Rehd et Wils (Lardizabalaceae) in animal models

Abstract: Purpose: To investigate the anti-thrombosis and anti-tumor effect of the water extract of the caulis of (IC50 value of 321.9, 285.0, 130.3 and 76.1 μg/mL, respectively. Furthermore,

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References 18 publications

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Recent advances in chemistry and bioactivity of Sargentodoxa cuneata

Screen for Potential Candidate Alternatives of Sargentodoxa cuneata from Its Six Adulterants Based on Their Phenolic Compositions and Antioxidant Activities

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