Anti-thrombotic effect of chronic oral treatment with Orbignya phalerata Mart.

Azevedo, Ana Cláudia; Farias, Jardel Cavalcante de; Costa, Graciomar C.; Ferreira, Susanne C.P.; Aragão-Filho, Walmir Cutrim; Sousa, Paulo R.A.; Pinheiro, Mayara T.; Maciel, Márcia C.G.; Silva, Lucilene A.; Lopes, Alessandra Santos; Barroqueiro, Elizabeth S.B.; Borges, Marilene O. R.; Guerra, Rosane Nassar Meireles; Nascimento, Flávia R.F.

doi:10.1016/j.jep.2006.11.005

Cited by 52 publications

(40 citation statements)

References 16 publications

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“…The reason that influenced its choice was easy extraction, preparation, drying, grinding, storage and application 21 , and also because its current use as medicine herbal, though without scientific confirmation 8,16 . Preclinical studies in mice showed that the extract of babassu mesocarp had beneficial effect on several circumstances 22 . It is used as food and in the treatment of various diseases; it has a wide distribution in Maranhão state in Brazil.…”

Section: Herbal Choice and Route Of Administrationmentioning

confidence: 99%

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

et al. 2016

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METHODS:Fifty four rats were used, distributed into three groups randomly: aroeira, babassu and control, which were divided into three subgroups (six animals) according to the time of the deaths (7, 14, 21 days). All underwent the same surgical procedure, cecotomy and cecorrhaphy. The animals in group aroeira and babassu received daily dose of 100 mg/kg of hydroalcoholic extract and 50 mg/kg of aquous extract respectively, by gavage. The control group received only saline solution. The parameters evaluated were: macroscopic changes, ,resistance test to air insufflations and histological changes. RESULTS:All animals showed good healing without infection. All groups presented adhesions between cecum and neighboring organs.The resistance test insufflating of atmospheric air showed progressive increase of pressure according to the days in the aroeira group, and decrease in babassu group, without significant difference. Microscopy showed significant difference in the polymorphonuclear, hyperemia, angiogenesis, fibroblast proliferation and collagen histological variables in the 14 th day. CONCLUSION:Hydroalcoholic extract of aroeira and the aqueous extract of babassu favored the healing process in cecorrhaphy in rats.

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Section: Herbal Choice and Route Of Administrationmentioning

confidence: 99%

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

et al. 2016

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“…Activated partial thromboplastin time assay is used to assess intrinsic clotting index and coagulation factors such as VIII, IX, XI, XII (Azevedo et al, 2007). Administration of B. orthobotrys aqueous methanolic extract revealed a highly significant increase in activated partial thromboplastin time in human and rabbit's serum in both in vitro and in vivo assays.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anticoagulant and thrombolytic activity of Berberis orthobotrys in animal model

Alamgeer

Tarar

Hasan

et al. 2018

Bangladesh J Pharmacol

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<p class="Abstract">Fundamental to this research was the evaluation of anticoagulant and thrombolytic potential of Berberis orthobotrys using clotting time, prothrombin time and activated partial thromboplastin time performed at 2.5, 5, 10% concentration. Aqueous-methanol extract significantly (p<0.05) increased the coagulation parameters both in human blood as well as in rabbit blood and exhibited the more salient effect on prolongation of these coagulation parameters at 10% concentration. Aqueous methanol extract (25, 50 and 100 mg/kg) produced the preferential increase in bleeding time and clotting time nevertheless the effect was more perceptible after 90 min at 100 mg/kg. Moreover, the crude extract presented a substantial increase in coagulation parameters after 7 days of administration in rabbits with more pronounced effects at the highest dose. HPLC profile of aqueous methanol extract revealed the presence of quercetin, p-coumaric acid, gallic acid, vanillic acid, 4-hydroxy-3-methoxy benzoic acid. Thus, the present study provides the pharmacological basis for its medical use in cardiovascular and other thrombotic disorders.</p>

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“…Inappropriate thrombus formation is related to a failure in homeostasis, and the major elements involved are coagulation factors, platelets and blood vessels (17). To investigate the activity of LCE in the coagulation process, we measured PT and APTT to evaluate the extrinsic and intrinsic routes of coagulation, respectively.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract

2011

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Abstract. Litchi chinensis Sonn. (lychee), which belongs to the family of Sapindaceae, is a subtropical evergreen tree that is cultivated throughout Southeast Asia, particularly in China. Litchi chinensis has been reported to have anti-inflammatory, antioxidant and antidiabetic activities. However, the antiplatelet and anticoagulant effects of Litchi chinensis have not been reported previously. In this study, we investigated the effects of a 70% ethanol extract from Litchi chinensis (LCE) on platelet aggregation, coagulation and fibrinolysis. LCE dose-dependently inhibited collagen-and ADP-induced platelet aggregation in rat platelet-rich plasma. LCE at 4 mg/ml had a maximal inhibitory effect on platelet aggregation. In particular, the LCE 4 mg/ml-treated group showed almost complete inhibition in the collagen-induced platelet aggregation assay. It also significantly prolonged coagulation times, such as the activated partial thromboplastin and prothrombin time, in rat platelet-poor plasma. We also investigated the fibrinolytic effects of LCE using the fibrin plate assay. LCE increased fibrinolytic activity in a dose-dependent manner. These results demonstrated the antithrombotic effects of LCE and suggest that Litchi chinensis may be a new natural source for the development of antiplatelet, anticoagulant and thrombolytic therapeutics for thrombotic and cardiovascular diseases. IntroductionPlatelets circulate in the blood and play essential roles in hemostasis and repair of the endothelial wall in a physiological state (1). This is achieved primarily by thrombus formation when damage occurs to the endothelial cell layer of blood vessels. However, excessive platelet aggregation produces a pathological thrombus and plays a major role in the initiation and pathogenesis of atherothrombotic diseases (2). An abnormal thrombus within the vascular system can obstruct the flow of blood and nutrients to important tissues. As a result, it can cause a variety of cardiovascular diseases, such as myocardial infarction, stroke and ischemic heart disease, and is a leading cause of death (3). Thus, inhibition of platelet aggregation is important in preventing the progression of atherosclerosis and arterial thromboses (4).A thrombus is composed of fibrin, which is produced from its precursor, fibrinogen, by thrombin. An inappropriate fibrin clot must be eliminated rapidly by fibrinolysis to maintain homeostasis (5). Dissolution of a fibrin clot is dependent on the action of plasmin, a serine protease that is activated by tissue plasminogen activator. In clinical therapy, thrombolytic agents (fibrinolytic enzymes), such as tissue plasminogen activator and urokinase, convert inactive plasminogen to active plasmin, allowing fibrinolysis to occur (6). Antiplatelet agents, such as aspirin and clopidogrel, are widely used and directly inhibit platelet aggregation. However, use of these agents is limited as they can lead to serious side effects, such as headache, vomiting, and gastric ulceration, and are costly (7,8).Litchi chinensis Son...

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Anti-thrombotic effect of chronic oral treatment with Orbignya phalerata Mart.

Cited by 52 publications

References 16 publications

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

Evaluation of anticoagulant and thrombolytic activity of Berberis orthobotrys in animal model

Antiplatelet, anticoagulant and fibrinolytic effects of Litchi chinensis Sonn. extract

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