Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA)—A 5-year follow-up of the Ehime study

Murao, Satoshi; Kondo, Shin‐ichiro; Ohashi, Jun; Fujii, Yasuhisa; Shimizu, Ikki; Fujiyama, Masao; Ohno, Keizo; Takada, Yasuharu; Nakai, Kazuaki; Yamane, Yukio; Osawa, Haruhiko; Makino, Hideichi

doi:10.1016/j.diabres.2008.01.024

Cited by 49 publications

(35 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are in line with data recently reported in a Japanese study, although in a very limited number of LADA patients, about an association between the presence of TPOAb and b-cell failure (27). Although at the moment we do not have any definite explanation of this finding, a possibility that should be considered is that the presence of extrapancreatic autoimmunity markers at diagnosis may reflect a more extended underlying immune process against b-cells.…”

Section: Discussionsupporting

confidence: 79%

Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults

Maioli¹,

Pes

Delitala³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: In latent autoimmune diabetes of adults (LADA), the progression into insulin-dependent diabetes is usually faster than in type 2 diabetes (T2D) but the factors influencing this progression are not completely known. In this study, we searched for sensitive markers associated with early development of insulin dependence. Design: The screening of 5568 T2D patients for glutamic acid decarboxylase autoantibodies (GAD65Ab) identified 276 LADA patients (MZ131; FZ145) and in 251 of them, tyrosine phosphatase-2 (IA-2Ab) and thyroperoxidase autoantibodies (TPOAbs), some clinical features and genotype variation of the main type 1 diabetes (T1D) disease susceptibility loci (HLA-DRB1 and HLA-DQB1) were analyzed. Results: Four years after the diagnosis of diabetes, high GAD65Ab titer was not significantly associated with faster progression toward insulin deficiency (PZ0.104). Patients with GAD65Ab and TPOAb or IA-2Ab or triple positivity for both islet and TPOAbs (GAD65Ab/IA-2Ab/TPOAb) showed a significantly faster disease progression (PZ0.002). Among 104 TPOAb-positive LADA patients, 10 received replacement therapy (L-thyroxine), 43 showed high TSH levels (62.7% developed insulin dependence), and 3 had hyperthyroidism treated with methimazole. Multivariate analysis revealed a significant effect on disease progression only for TPOAb (PZ0.022), female gender (PZ0.036), low body mass index (BMI; PZ0.001), and T1D high/intermediate risk HLA-DRB1/DQB1 genotypes grouped (PZ0.020). Conclusions: High GAD65Ab titers per se are not a major risk factor for disease progression in LADA, while the number of positive autoantibodies and HLA DRB1-DQB1 genotypes at high risk for T1D are significant predictors. Moreover, clinical characteristics such as low BMI and female gender are more likely to identify patients who will require insulin therapy within 4 years of diagnosis.

show abstract

Section: Discussionsupporting

confidence: 79%

Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults

Maioli¹,

Pes

Delitala³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Third, we could not investigate the relationship between the GADA-ELISA readings and other islet cell-associated autoantibodies (anti-IA-2 antibody, anti-ZnT8 antibody, IAA and ICA) because measuring the islet cell-associated autoantibodies in patients diagnosed as type 1 DM is limited in clinical practice covered by health insurance in Japan. Fourth, the presence of anti-thyroid peroxidase antibody, which was reported to facilitate the estimation of future progression to the insulin-dependent state in SPIDDM regardless of GADA-RIA values [17], could not be obtained in the present study. In the future, we will clarify the association between the values of the anti-thyroid peroxidase antibody test and the GADA-ELISA test.…”

Section: Discussioncontrasting

confidence: 47%

Slowly progressive insulin-dependent (type 1) diabetes positive for anti-GAD antibody ELISA test may be strongly associated with a future insulin-dependent state

et al. 2017

View full text Add to dashboard Cite

“…LADA patients have been reported to be more commonly positive for HLA DR3 and DR4 and their associated DQb1 alleles 0201 and 0302, which have been linked to a predisposition to childhood type 1 diabetes (31,39,56 ). In contrast, the HLA DR2 and DQb1*0602, which has been associated with protection from childhood type 1 diabetes, has also been reported to be relatively common in LADA patients (57 ).…”

Section: T-cell Responses To Islets In T2dm and Lada Patientsmentioning

confidence: 92%

Latent Autoimmune Diabetes in Adults

Brooks-Worrell

Palmer

2010

Immunoendocrinology: Scientific and Clinical Aspects

View full text Add to dashboard Cite

Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA)—A 5-year follow-up of the Ehime study

Cited by 49 publications

References 44 publications

Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults

Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults

Slowly progressive insulin-dependent (type 1) diabetes positive for anti-GAD antibody ELISA test may be strongly associated with a future insulin-dependent state

Latent Autoimmune Diabetes in Adults

Contact Info

Product

Resources

About