Anti-Toxoplasma antibodies in Egyptian rheumatoid arthritis patients

Elhenawy, Abeer A.; Hafez, Eman Abdel Razek; Nabih, Nairmen; Shalaby, Naglaa M; Mashaly, Mervat

doi:10.1007/s00296-017-3703-8

Cited by 17 publications

(21 citation statements)

References 43 publications

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“…The higher seroprevalence of anti- T. gondii IgG antibodies among RA patients versus control patients reflects an association between latent T. gondii infection and RA. Contrastingly, there was no signficant difference between RA patients and controls with regard to the level of IgM antibodies, which was found to be consistent with a previous study reporting no anti- T. gondii IgM in RA patients [ 25 ]. Among the various clinical forms of arthritis, seroprevalence rates of only rheumatoid arthritis (24.8%; P < 0.001) and reactive arthritis (23.8%; P = 0.002) were significantly raised when compared with controls.…”

Section: Discussionsupporting

confidence: 91%

“…Patients with arthritis were more likely to be infected with T. gondii (18.8% compared to 12% of healthy controls, P < 0.001), based on IgG seropositivity. Correlation between T. gondii infection and RA has been reported in other geographical areas, for example Iraq (54.0%) [ 22 ], Tunisia (58.4%) [ 23 ], Europe (63.0%) [ 17 ], and Egypt (54.0% [ 24 ] and 76.7% [ 25 ]). The higher seroprevalence of anti- T. gondii IgG antibodies among RA patients versus control patients reflects an association between latent T. gondii infection and RA.…”

Section: Discussionmentioning

confidence: 89%

“…Patients with arthritis should be monitored for early signs of opportunistic infection and, if confirmed, it may be necessary to withdraw anti-TNF-α therapy until the infection is properly treated. One study, based on a small sample of only 30 individuals, reported no difference in the level of anti- T. gondii IgG antibodies among RA patients undergoing treatment with traditional disease-modifying antirheumatic drugs or biological TNF inhibitors [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Tian

Zhou

et al. 2017

Infect Dis Poverty

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BackgroundThere is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of data on the magnitude of T. gondii infection in these patients.MethodsSeroprevalence of T. gondii infection was assessed by enzyme-linked immunosorbent assay using a crude antigen of the parasite in 820 arthritic patients, and an equal number of healthy controls, from Qingdao and Weihai cities, eastern China. Sociodemographic, clinical and lifestyle information on the study participants were also obtained.ResultsThe prevalence of anti-T. gondii IgG was significantly higher in arthritic patients (18.8%) compared with 12% in healthy controls (P < 0.001). Twelve patients with arthritis had anti-T. gondii IgM antibodies – comparable with 10 control patients (1.5% vs 1.2%). Demographic factors did not significantly influence these seroprevalence frequencies. The highest T. gondii infection seropositivity rate was detected in patients with rheumatoid arthritis (24.8%), followed by reactive arthritis (23.8%), osteoarthritis (19%), infectious arthritis (18.4%) and gouty arthritis (14.8%). Seroprevalence rates of rheumatoid arthritis and reactive arthritis were significantly higher when compared with controls (P < 0.001 and P = 0.002, respectively). A significant association was detected between T. gondii infection and cats being present in the home in arthritic patients (odds ratio [OR], 1.68; 95% confidence interval [CI]: 1.24 – 2.28; P = 0.001).ConclusionsThese findings are consistent with and extend previous results, providing further evidence to support a link between contact with cats and an increased risk of T. gondii infection. Our study is also the first to confirm an association between T. gondii infection and arthritis patients in China. Implications for better prevention and control of T. gondii infection in arthritis patients are discussed.Trial registrationThis is an epidemiological survey, therefore trial registration was not required.Electronic supplementary materialThe online version of this article (10.1186/s40249-017-0367-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Tian

Zhou

et al. 2017

Infect Dis Poverty

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“…We identified 11 datasets from the nine articles that met the inclusion criteria, eight of which were case-control, two cross-sectional, and one were cohort studies ( Table 1 ). The surveys were conducted in Latin America [ 14 ], Europe [ 14 , 16 ], Egypt [ 24 , 25 ], Iraq [ 22 , 23 , 27 ], Czech and Slovak [ 26 ], and China [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis

et al. 2018

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BackgroundToxoplasmosis is a cosmopolitan infection caused by an intracellular obligatory protozoan, Toxoplasma gondii. Infection to this parasite in immunocompetent patients is usually asymptomatic, but today it is believed that the infection can be a risk factor for a variety of diseases, including rheumatoid arthritis (RA). RA is an autoimmune disease and the most common type of inflammatory arthritis that is a major cause of disability. The aim of this systematic review and meta-analysis was to address the association between RA and toxoplasmosis in light of the available research.MethodsBased on the keywords, a systematic search of eight databases was conducted to retrieve the relevant English-language articles. Then, the studies were screened based on the inclusion and exclusion criteria. The random effect model was used to calculate the odds ratio (OR) using forest plot with 95% confidence interval (CI).ResultsOverall, 4168 Individual, extracted from 9 articles were included for systematic review evaluation, with 1369 RA patients (46% positive toxoplasmosis) and 2799 individuals as controls (21% positive toxoplasmosis). Then, eight articles (10 datasets) were used for meta-analysis (1244 rheumatoid arthritis patients and 2799 controls). By random effect model, the combined OR was 3.30 (95% CI: 2.05 to 5.30) with P < 0.0001.ConclusionAlthough toxoplasmosis could be considered as a potential risk factor for rheumatoid arthritis, more and better quality studies are needed to determine the effect of T. gondii infection on induction or exacerbation of RA. Our study was registered at the International Prospective Register of Systematic Reviews (PROSPERO; code: CRD42017069384).

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“…J. Schmikler зі співавторами [56] підтвердили зв'язок між виникнен ням РА та наявністю Porphyromonas Gingivalis у ротовій порожнині. Дослідження показали, що у хворих на РА зпоміж інших мікроорґанізмів є висока поши реність антитіл IgG до Toxoplasma gondii [21]. Зво ротну кореляцію виявлено між високими титрами антитіл IgG до вірусу М.Е.…”

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Peculiarities of Calcium-Phosphorus Metabolism and Bone State in Patients with Rheumatoid Arthritis: Pathogenesis, Diagnosis and Principles of Differential Treatment (Literature Review and Clinical Case Description)

Chemes¹,

Abrahamovych²,

Abrahamovych³

et al. 2019

Lʹviv. klin. visn.

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Anti-Toxoplasma antibodies in Egyptian rheumatoid arthritis patients

Cited by 17 publications

References 43 publications

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis

Peculiarities of Calcium-Phosphorus Metabolism and Bone State in Patients with Rheumatoid Arthritis: Pathogenesis, Diagnosis and Principles of Differential Treatment (Literature Review and Clinical Case Description)

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