Anti-TTG Among Children With Chronic Functional Constipation Unresponsive to 6 Weeks of Treatment of Constipation

Abstract

BACKGROUND Celiac disease is a glutten induced enteropathy. Some authors recommended screening celiac in children with constipation. There are studies to evaluate celiac disease in children with constipation. But most of them included children regardless to treatment failure. OBJECTIVE The aim of this study was to evaluate frequency of elevated anti TTG in children with constipation after failure to improve during 6 week of appropriate treatment of constipation. METHODS In this cross sectional study, 550 children with prolonged constipation were included. Place of study was Pediatric Gastroenterology clinic of Abuzar children’s hospital. Prolonged constipation was defined as a constipation which failed to resolved after 6 weeks of appropriate treatment. Constipation was defined according to ROME III criteria. After parental agreement, 5 mL of blood was obtained. Serum anti TTG level was measure using ELISA method by Orientec kit. Anti TTG>10 was considered positive if IgA was normal. SPSS version 16.0 (Chicago, IL, USA) was used for data analysis. Chi square, t-test, and Mann Whitney test used for data analysis. RESULTS In this study 550 children (m=277, f=273) were included. Mean age of the cases was 6.8±2.9 year. Anti TTG antibody level was 5.8±2.8 unit/mL. Of these case, 42 (7.6%) had positive anti-TTG antibody. Celiac disease was confirmed in 40 cases after histopathology examination. CONCLUSION Anti-TTG was positive in 7.6% children with chronic constipation who failed to respond after 6 week of treatment. Another multicenter study with longer follow up period is recommended.

Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike

“…In an Italian study it was found in 13% of celiac patients, which is similar to our results of 9% of men and 20% of women [25]. Studies on patients with chronic constipation show high rates of CD in both adults and children [26,27,28]. This finding in our study may be confounded by patient reporting of symptoms leading to recall bias as well as other disorders such as pelvic floor dysfunction and irritable bowel syndrome constipation type which predominate in women.…”

Evaluation of Rheography of the Colon in Idiopathic Megarectosigmoidi in Children

“…В последние годы многие исследователи уделяют большое внимание кишечному кровотоку, так как от его состояния зависит течение воспалительных процессов и заживление анастомозов после реконструктивных операций на кишечнике. Однако, как говорилось выше, все исследования по определению гемодинамики кишечника в основном проводились в опытах на животных или интраоперационно [13][14][15]. Среди применяемых для этой цели методов исследования следует выделить реографию, которая широко используется для исследования упруго-вязких свойств артериальных сосудов, что дает возможность судить о ходе гемодинамических процессов как в исследуемых органах, так и в целом по регионарному и центральному звеньям кровообращения.…”

Chronic constipation in pediatric practice: what do we know? Anything new?

“…Исследование уровня антител к тканевой трансглутаминазе показало, что у 42 из 550 (7,6%) имелись повышенные значения. В дальнейшем у 40 из 42 (95%), выявленных при серологическом скрининге, гистологически подтверждена целиакия [23].…”