Anti-tuberculosis activity of bio-active compounds from Lantana camara L., Euphorbia hirta L., Mukia maderaspatana (L.) M. Roem, and Abutilon indicum (L.)

Nirmal, Christy Rosaline; Ebenezer, Rajadas Sam; Kannan, Priya; Balasubramanian, Mahizhaveni; Thirunavukkarasu, Indira; Mondal, Rajesh; Dusthackeer, Azger

doi:10.1016/j.eujim.2020.101105

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…The present work highlights the use of leaf extracts of the plant (L. camera) and earthworm (Pheretima posthuma). L. camara has been reported to contain almost 29 active fractions like tannins, saponins, steroids, and terpenoids which are potent antimicrobial agents and have been reported to inhibit the growth of bacteria (Nirmal et al, 2020). Similar findings have been reported (Byzov, Khomyakov, Kharin, & Kurakov, 2007), highlighting that the gut fluid of earthworm have some potent antibacterial metabolites of symbiotic bacteria does not lower with partial sterilization of the gut (Bhorgin & Uma, 2014).…”

Section: Resultsmentioning

confidence: 71%

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Antimicrobial Activity of Lantana Camara Against Pseudomonas Aeruginosa, Serratia Marcescens and Staphylococcus Aureus to Develop Ointment Based Therapy

DIN¹,

FAZAL

Ishtiaque

et al. 2023

Bull. Biol. All. Sci. Res.

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Plant extract (Lantana camara) and earthworm (Pheretima posthuma) extract have been used to treat many illnesses for centuries; they have been reported to suppress the growth of many pathogenic bacteria and are specially used for wound healing. We analyzed the antibacterial activity of the different organic extracts obtained from these species against pathogenic strains of bacteria and compared them to know which is more potent for developing antiseptic ointment. Ethanol and acetone solvents were used for the extraction and analyzed for their antibacterial activity by the disk diffusion and shake flask test. Then we identified the minimum inhibitory concentration of extracts against gram-positive and gram-negative strains. Lantana camara showed the largest growth inhibitory zone against Pseudomonas aeruginosa, followed by Serratia marcescens, and Staphylococcus aureus. MIC for plant extract was 150μg/ml, while earthworm extract inhibited growth at a minimum dose of 200μg/ml. We found that the plant's ethanol extract (L. camara) exhibited robust antimicrobial activity compared to the worm extract. Current investigation reinforces the application of Lantana camara extract to develop ointment to treat wound infections.

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Section: Resultsmentioning

confidence: 71%

“…(Nayak, Raju, & Ramsubhag, 2008). Many bioactive fractions like alkaloids, Flavonoids, Phenols, Tannins, and Terpenoids have been detected in the extract and seem to have a role in antimicrobial activity (Nirmal et al, 2020). Earthworms live in soil which increases soil fertility.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Lantana Camara Against Pseudomonas Aeruginosa, Serratia Marcescens and Staphylococcus Aureus to Develop Ointment Based Therapy

DIN¹,

FAZAL

Ishtiaque

et al. 2023

Bull. Biol. All. Sci. Res.

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“…The main group of bioactive phytochemicals of E. hirta, which have been distinguished and identified as illustrated in Fig. 2 includes, flavonoids, steroids, terpenoids, coumarins, tannins and polyphenols 38,39,40 . Phytochemical analysis of leaf extract revealed the presence of carbohydrates, terpenoids, alkaloids, reducing sugars, steroids, tannins, proteins, fats, oils, mucilages, glycoside, saponin, coumarin, anthraquinones, chlorophyll, and carotenoids 41 .…”

Section: Phytochemistrymentioning

confidence: 99%

Untitled

2022

IJPSR

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Euphorbia hirta Linn. (Euphorbiaceae), commonly known as 'Dudhy' is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorder, bronchitis, and in asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydro-alcoholic extract of E. hirta has more pharmacological activities. It is used as an important medicinal and nutritional source for curing many severe illnesses in different parts of the world. Therefore, it is the need of the modern time to isolate and identify more bioactive constituents and elucidate their structure, activity and relationship of this plant. It is also emphasized for more detailed research and clinical trials to explore its pharmacological activity and clinical efficacy. INTRODUCTION:Euphorbia hirta Linn. is commonly known as milkweed (Dudhy) and asthma plant. It is known by the different names in different parts of the world 1, 2 . The plant is characterized by the presence of milky white latex which is more or less toxic. Latices of E. ingens, E. tirucalli, E. mey, and E. triangularis are possible sources of rubber 3 .

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“…In the essential oil that is obtained from this species, several bioactive compounds are found, such as terpenoids, alkaloids, avonoids, phenolic compounds, and glycosides. These compounds are to which various biological activities have been attributed, such as anticancer and antiangiogenic (Al-Hakeim et al, 2021), anti-in ammatory (Wu et al, 2020), anti-tuberculosis (Nirmal et al, 2020), as well as a sedative (Dougnon, Ito, 2020). This is in addition to antifungal (Bashir et al, 2019), herbicide (Qureshi, et al, 2019), nematicide (Borbodoli et al, 2021), insecticide (Ayalew, 2020), and trypanocide agents (Delgado-Altamirano et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Anti-Phytomonas activity of the lyophilized residues obtained from the distillation of Lantana camara L. essential oil

Soares,

Santos,

Nascimento

et al. 2024

Preprint

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On an industrial scale, the residues accumulated in essential oil distilleries can be compared to the volume of residues produced in a textile industry. Although these residues are discarded, they possess molecules with diverse biological activities, including their application in phytopathogen control. In this study, the chemical profile of the residue from the hydrodistillation of Lantana camara L. leaves was determined using High-Performance Liquid Chromatography (HPLC). Additionally, the effect of the residue on cells was assessed by determining plasma membrane integrity, levels of reactive oxygen species (ROS) production, and mitochondrial potential depolarization. The viability and cell density of Phytomonas serpens parasites significantly decreased after treatment with increasing concentrations of the lyophilized residue. RL038, the lyophilized residue from accession LAC-038, reduced cell viability by an average of 61.36%. ROS levels increased by approximately 2x and 3x at RL038 concentrations of 120 µg/mL and 180 µg/mL, respectively. It was observed that the same concentrations modified mitochondrial potential, reducing fluorescence by 44.6% and 46.8%, respectively. Analytical liquid chromatography of RL038 revealed the presence of 17 peaks subsequently classified as phenolic acids and flavonoids. RL038 from the hydrodistillation of Lantana camara L. leaves is a source of biologically active compounds with antiprotozoal potential.

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Anti-tuberculosis activity of bio-active compounds from Lantana camara L., Euphorbia hirta L., Mukia maderaspatana (L.) M. Roem, and Abutilon indicum (L.)

Cited by 14 publications

References 34 publications

Antimicrobial Activity of Lantana Camara Against Pseudomonas Aeruginosa, Serratia Marcescens and Staphylococcus Aureus to Develop Ointment Based Therapy

Antimicrobial Activity of Lantana Camara Against Pseudomonas Aeruginosa, Serratia Marcescens and Staphylococcus Aureus to Develop Ointment Based Therapy

Untitled

Anti-Phytomonas activity of the lyophilized residues obtained from the distillation of Lantana camara L. essential oil

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