Anti-tumor activity and linear-diarylheptanoids of herbal couple Curcumae Rhizoma-Sparganii Rhizoma and the single herbs

Chang, Yanli; Xu, Guanling; Wang, Xiaoping; Yan, Xin; Xu, Xiao; Li, Xiao; Chen, Zikang; Ren, Xuan; Chen, Xi-Qin; Zhang, Jinghan; Wang, Xiuhuan; Ren, Xueyang; Liu, Xiaoyun; Wang, Yu; Sun, Siqi; Li, Xiang; She, Gaimei

doi:10.1016/j.jep.2019.112465

Cited by 29 publications

(18 citation statements)

References 36 publications

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“…The product ions of compound 31 at m/z 177.09, 163.07 and 137.06 were also 30.01 m/z units less than those at m/z 207.10, 193.09 and 167.07, which supported the proposed structure of compound 31 (Table 1, Figure 1). Based on this information, compound 31 was tentatively identified as 1,7‐bis(4‐hydroxy‐3‐methoxyphenyl)heptane‐3,5‐diol 25 . The proposed fragmentation pathways of compounds 17 , 19 , 30 and 31 are shown in Figure 4.…”

Section: Resultsmentioning

confidence: 98%

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Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Wang

et al. 2021

Rapid Comm Mass Spectrometry

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Rationale Ginger pulp is the dried rhizome scraped off the skin which originates from Zingiber officinale Rosc., a Zingiberaceae plant. Ginger peel is the dried rhizome skin of Zingiber officinale Rosc. (Zingiberaceae). The present work aims to investigate the different chemical constituents that are related to the medicinal properties of the ginger pulp and ginger peel. Methods A rapid ultra‐high‐performance liquid chromatography/electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry (UHPLC/ESI‐QTOF/MS) method was developed for qualitative analysis of the constituents in different polarity extracted fractions of the pulp and peel of ginger rhizomes. Results A total of 83 compounds were identified from the pulp and peel of ginger rhizomes, including 36 diarylheptanoids, 25 gingerols and 22 other compounds. Nine of these were new compounds. In total, 46, 27, 65 and 51 compounds were identified from the crude extract, petroleum ether, ethyl acetate, and n‐butanol fractions of the ginger pulp, respectively, and 60, 30, 70 and 62 compounds were identified from the crude extract, petroleum ether, ethyl acetate, n‐butanol fractions of the ginger peel, respectively. Each identified compound is marked on the corresponding chromatogram. Conclusions The integrated method is sensitive and reliable for searching the different chemical constituents from different polarity extracted fractions of the ginger pulp and ginger peel. This work may provide a significant contribution to research into the medicinal properties of the ginger pulp and ginger peel.

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Section: Resultsmentioning

confidence: 98%

“…Based on this information, compound 31 was tentatively identified as 1,7-bis (4-hydroxy-3-methoxyphenyl)heptane-3,5-diol. 25 The proposed fragmentation pathways of compounds 17, 19, 30 and 31 are shown in Figure 4. 1 hydroxy group.…”

Section: Characterization Of Linear Diarylheptanoidsmentioning

confidence: 99%

Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Wang

et al. 2021

Rapid Comm Mass Spectrometry

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“…CRSR, a classical herb pair used to promote blood circulation and remove blood stasis, is commonly used in the treatment of gynecological tumors (13)(14)(15)(16). Curcumae Rhizoma has antitumor, antiplatelet aggregation, antithrombosis, hepatoprotective, antimicrobial, and other pharmaceutical activities.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Zhang

et al. 2021

Front. Public Health

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Uterine leiomyoma (UL), common benign tumors in women of child-bearing age, are believed to be caused mainly by Qi stagnation and blood stasis, according to a theory of traditional Chinese medicine. Curcumae Rhizoma and Sparganii Rhizoma (CRSR) is a classical herb pair that activates blood circulation to dissipate blood stasis. The purpose of this study was to explore the prevention and treatment effects of CRSR component compatibility on UL in rats. We randomly assigned adult female non-pregnant rats into three groups: a normal control (NC) group, a UL model group, and a CRSR treatment group. We administered to the UL and CRSR groups oral gavage diethylstilbestrol and injected them with progesterone (P) to establish UL for 5 weeks. The CRSR group received a CRSR medicinal solution after daily modeling. The uterus morphology of the UL group showed significantly more swelling than did that of the NC group, and we found no significant abnormalities in the morphology of the CRSR group. The pathological changes associated with UL were relieved in the CRSR group. CRSR improved the related parameters of the uterus and ovarian coefficients, significantly reducing the concentrations of P in the serum and the concentrations of estradiol, P, estrogen receptor, and P receptor in the uterus and ovary. In addition, CRSR significantly improved the abnormal blood conditions of UL, shown by decreases in plasma viscosity, the erythrocyte sedimentation rate equation K value, and erythrocyte aggregation index. Therefore, CRSR component compatibility may prevent and cure UL through the above ways.

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“…Zedoary turmeric oil is a volatile oil extracted from Rhizoma Sparganii (RC). As an effective anti-tumor drug (Chang et al, 2019), the main active ingredients of zedoary turmeric oil are curcumin, curcumin diketone and β-elemene (Dosoky and Setzer, 2018).…”

Section: Rhizoma Curcumae and Rhizoma Sparganii (Rcrs) Is Frequently mentioning

confidence: 99%

Inhibition of Fibroblast Activation by Components of Rhizoma Curcumae and Rhizoma Sparganii in A Rat Model of Uterine Leiomyoma

Feng

Zhao

et al. 2020

Preprint

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Background: Traditional Chinese medicine (TCM) often uses Rhizoma Curcumae and Rhizoma Sparganii (RCRS) ，the natural herbs for the treatment of UL. RCRS has been shown to be effective in the treatment of UL in our previous study. This study was to investigate the molecular mechanism by which RCRS inhibits fibroblast activation protein (FAP) activation and prevents uterine leiomyoma in rats. Methods: The SD rat model of uterine leiomyoma was established by estrogen and progesterone load combined with external stimulation. Subsequently, histological analyses, enzyme-Linked immunosorbent assays, western blotting were performed to evaluate the effect of the drug on uterine leiomyoma and its mechanism. Results: Our data showed that treatment of rats with RCRS significantly reduced the expression of FAP, TGF-β (the FAP activating factor), and significantly decreased the phosphorylation of cell proliferation pathway-related signaling factors AKT/MEK/ERK, as well as the expression of the extracellular matrix component collagen. Conclusions: Our results showed that RCRS is very effective in prevention and treatment of uterine leiomyoma in rats, and RCRS may exert its actions by inhibiting the activation of tumor-associated fibroblasts, inhibiting the cell proliferation, and improving tumor extracellular matrix.

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Anti-tumor activity and linear-diarylheptanoids of herbal couple Curcumae Rhizoma-Sparganii Rhizoma and the single herbs

Cited by 29 publications

References 36 publications

Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Inhibition of Fibroblast Activation by Components of Rhizoma Curcumae and Rhizoma Sparganii in A Rat Model of Uterine Leiomyoma

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