Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model

Chernysh, Sergey; Kozuharova, Irina; Irina, Artsibasheva

doi:10.1016/j.intimp.2011.10.016

Cited by 54 publications

(25 citation statements)

References 8 publications

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“…The antihepatoma effect of artesunate API and artesunate nanoliposomes was concentration-dependent within a certain concentration range (Bar-On et al, 2007;Lu et al, 2011;Chernysh et al, 2012). Experimental screening concentrations were 6.25-200 mg ml.…”

Section: Discussionmentioning

confidence: 99%

“…Artesunate nanoliposomes released drug in a sustained release manner (Carmona-Ribeiro, 2003;Sahoo et al, 2007;Chernysh et al, 2012). The effect of artesunate nanoliposomes on HepG2 cells proliferation was weaker than that of API at low dose within 24 h. 72 h after the effect of artesunate API were dramatically decreased, but nanoliposomes remained the same.…”

Section: Discussionmentioning

confidence: 99%

“…The appropriate biofilm liquidity ensured the implementation of the membrane energy conversion, material transport, information transmission and other important biological functions. A decrease of mitochondrial membrane fluidity led to the disorder material transport, rapid disappearance of ionic concentration gradients inside and outside mitochondria (BarOn et al, 2007;Krishna et al, 2008;Lu et al, 2011;Chernysh et al, 2012), which might be one of the mechanisms that induces cell apoptosis, which might be one of the mechanisms that induces cell apoptosis. This indicated that artesunate nanoliposomes may be a potential drug for hepatocellular carcinoma patients, which may lead to the development of promising anticancer drug delivery systems applied to a wide range of cancers including hepatocellular carcinoma therapy (Donnelly et al, 2010;Reznikov et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The in vitro hepatoma HepG-2 cells in the log phase were harvested, single-cell suspensions were prepared at a concentration of 1 Â 10 7 viable cells/ml, and the mice were injected subcutaneously in the left flank with 0.2 ml of the cell suspension (Bar-On et al, 2007;Shen et al, 2010;Chernysh et al, 2012). The mice were observed everyday.…”

Section: Establishment Of a Hepatocellular Carcinoma (Hcc) Xenograft mentioning

confidence: 99%

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In vivostudy of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice

et al. 2013

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To investigate the effect of artesunate nanoliposomes on cultured cells in vitro and hepatocellular carcinoma xenografts in BALB/c-nu mice. Fluorescence polarization was applied for measurement of mitochondrial membrane fluidities; inhibition test of tumor cell proliferation in vitro was performed and nude mice xenograft model from human hepatocellular carcinoma (HCC) was established. Cytotoxicity of these compounds was evaluated by MTT assay on hepatocellular carcinoma xenografts in nude mice. Anisotropy (r-value) of blank nanoliposomes didn't change, it had no statistically significance between the blank nanoliposomes group and the control group, it indicated that artesunate had no obvious effect on L-O2 human normal liver cells. IC 50 values of artesunate nanoliposomes and artesunate API (active pharmaceutical ingredient) against HepG-2 cells were 15.997 and 19.706 mg/ml; IC 50 values of the same drugs against L-O2 normal human liver cells were 100.23 and 105.54 mg/ml, respectively. Tumor growth inhibitory effect of artesunate nanoliposomes was 32.7%, and artesunate API was 20.5%, respectively. HepG-2 cells treated with artesunate nanoliposomes showed dose-dependent apoptosis. The antitumor effect of artesunate nanoliposomes on human hepatoma HepG2 cells were stronger than that of artesunate API at the same concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Establishment Of a Hepatocellular Carcinoma (Hcc) Xenograft mentioning

confidence: 99%

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In vivostudy of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice

et al. 2013

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“…Synthetic alloferon in in vitro tests stimulated natural killer cells, while in vivo interferon was induced in mice. There were also indications of antiviral and antitumour activities [144] with alloferon also showing moderate tumoristatic and tumoricidal activities in transplanted tumours in mice [165]. More recently, a derivative of alloferon, allostatin, has been shown to have a significant adjuvant effect in vaccination experiments against tumour cells in mice [166].…”

Section: Maggot Moleculesmentioning

confidence: 99%

Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

Ratcliffe

Azambuja

Mello

2014

Evidence-Based Complementary and Alternative Medicine

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Except for honey as food, and silk for clothing and pollination of plants, people give little thought to the benefits of insects in their lives. This overview briefly describes significant recent advances in developing insect natural products as potential new medicinal drugs. This is an exciting and rapidly expanding new field since insects are hugely variable and have utilised an enormous range of natural products to survive environmental perturbations for 100s of millions of years. There is thus a treasure chest of untapped resources waiting to be discovered. Insects products, such as silk and honey, have already been utilised for thousands of years, and extracts of insects have been produced for use in Folk Medicine around the world, but only with the development of modern molecular and biochemical techniques has it become feasible to manipulate and bioengineer insect natural products into modern medicines. Utilising knowledge gleaned from Insect Folk Medicines, this review describes modern research into bioengineering honey and venom from bees, silk, cantharidin, antimicrobial peptides, and maggot secretions and anticoagulants from blood-sucking insects into medicines. Problems and solutions encountered in these endeavours are described and indicate that the future is bright for new insect derived pharmaceuticals treatments and medicines.

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Recent Advances in the Insect Natural Product Chemistry: Structural Diversity and Their Applications

Rather

Ansari

2020

Natural Materials and Products From Insects: Chemistry and Applications

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Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model

Cited by 54 publications

References 8 publications

In vivostudy of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice

In vivostudy of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice

Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

Recent Advances in the Insect Natural Product Chemistry: Structural Diversity and Their Applications

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