Anti-tumor activity of polysaccharides extracted fromPinus massonianapollen in colorectal cancer-in vitroandin vivostudies

Shang, Hongqi; Niu, Xiangyun; Cui, Wenping; Zhou, Sha; Wang, Cheng; Teng, Hao; Guo, Ping; Wang, Xiangkun; Gao, Panpan; Zhang, Shuyu; Wei, Kai; Zhu, Rui‐Liang

doi:10.1039/d1fo03908c

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…The homogeneity and molecular weight were measured with an Agilent 1260 Infinity size exclusion chromatography and gel permeation chromatography system equipped with an Agilent RID-7115A refractive index detector (Agilent Technologies, Palo Alto, CA, USA) and a gel-filtration chromatography column (TSK-gel G3000PWXL column, 7.8 × 300 mm i.d., 7 μm; Tosoh Bioscience LLC, Tokyo, Japan). Dextran standards (1,5,12, 50, 80 and 270 kDa) were used for calibration. Elution was performed with 0.02 M ammonium acetate solution at a rate of 0.6 mL min −1 and maintained at 35 ± 1 °C.…”

Section: Structural Characterization Of Gp90mentioning

confidence: 99%

“…11 Studies have also shown that Pinus massoniana pollen polysaccharide treated colon cells exhibit electron-lucent cytoplasm and nuclei as well as cytoplasmic vacuolization, which are characteristic of apoptosis caused by ferroptosis. 12 The question remains whether the auxiliary antitumor activity of GPs is related to the induction of ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

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Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Cai

Luo²,

Chen

et al. 2023

Food Funct.

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Section: Structural Characterization Of Gp90mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Cai

Luo²,

Chen

et al. 2023

Food Funct.

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“…The RNA extraction and quantitative real-time polymerase chain reaction (qPCR) were performed as previously described. 11,12 The expression of each target gene messenger RNA (mRNA) in liver and jejunum tissues was detected by qPCR. TRIzol reagent (no.…”

Section: Real-time Quantitative Pcrmentioning

confidence: 99%

Comparison study of protective effects of porcine bile acids and sheep bile acids against heat stress in chickens

Liu

Wang

et al. 2023

J Sci Food Agric

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BACKGROUND Heat stress (HS) is known to exert negative effects on the poultry and breeding industry, resulting in severe economic losses. Bile acids (BAs), an important component of bile, play a crucial role in improving the production performance of livestock and poultry, alleviating stress injury, and ensuring the health of livestock and poultry. At present, porcine BAs are widely used because of their therapeutic effects on HS; however, it remains unclear whether the same effects are exerted by sheep BAs, which are different from porcine BAs and have different compositions. In this study, we compared the anti‐HS effects of porcine BAs and sheep BAs in the diet by establishing an HS model of chicks and investigating the chicken performance, HS‐related genes' expression, oxidative stress markers, jejunal histoarchitecture, inflammatory cytokines' expression, jejunal secreted immunoglobulin A concentration, and cecal bacterial flora. RESULTS The results showed that the addition of sheep BAs to the diet increased the average daily weight gain and the feed conversion ratio of chicks. Under HS, sheep BAs were more effective than porcine BAs in improving the activities of lactate dehydrogenase and glutamic pyruvic transaminase in serum and the content/activity of malondialdehyde, superoxide dismutase, and reduced glutathione in serum and tissue, in reducing the messenger RNA (mRNA) expression of heat shock proteins (HSP60, HSP70, and HSP90) in the liver and jejunum, and in improving the histological structure and the expression of tight junction proteins (occludin and zonula occludens‐1) and enriching intestinal bacterial flora. However, porcine BAs were significantly inferior to sheep BAs in reducing the mRNA expression of inflammatory factors (interleukin‐6, interleukin‐1β, and tumor necrosis factor‐α). CONCLUSION The effect of sheep BAs was more significant than porcine BAs was in alleviating HS injury in chicks, suggesting that sheep BAs have great potential as new feed nutrition and health additive to improve poultry production performance and prevent HS. © 2023 Society of Chemical Industry.

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“…Polysaccharides act against tumor cells directly or indirectly. Their direct antitumor effects are reflected in their ability to induce apoptosis in cancer cells, block the cell cycle, and inhibit tumor cell invasion, adhesion, metastasis, and growth (Shi et al, 2013;Shang et al, 2022). Secondly, the indirect antitumor effects of polysaccharides involve enhancing immune function (Feng et al, 2019).…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Vitamin A and Vitamin B12 Influencing the composition of the intestinal flora. Shao et al, 2021;Shang et al, 2022 Dietary patterns Mediterranean diet ω-3 polyunsaturated fatty acids, phytochemicals inhibit the expression of colonic inflammatory factors. Shi et al, 2013;Si et al, 2021 Vegetarian diet Reducing the intake of red meat and animal protein, adequate dietary fiber, etc., which can increase the microbial diversity of the intestine.…”

Section: Shadnoush Et Al 2013mentioning

confidence: 99%

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Chen

Lin

et al. 2022

Front. Microbiol.

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Colorectal cancer (CRC) ranks third in terms of global incidence and second in terms of death toll among malignant tumors. Gut microbiota are involved in the formation, development, and responses to different treatments of CRC. Under normal physiological conditions, intestinal microorganisms protect the intestinal mucosa, resist pathogen invasion, and regulate the proliferation of intestinal mucosal cells via a barrier effect and inhibition of DNA damage. The composition of gut microbiota and the influences of diet, drugs, and gender on the composition of the intestinal flora are important factors in the early detection of CRC and prediction of the results of CRC treatment. Regulation of gut microbiota is one of the most promising new strategies for CRC treatment, and it is essential to clarify the effect of gut microbiota on CRC and its possible mechanisms to facilitate the prevention and treatment of CRC. This review discusses the role of gut microbiota in the pathogenesis of CRC, the potential of gut microbiota as biomarkers for CRC, and therapeutic approaches to CRC based on the regulation of gut microbiota. It might provide new ideas for the use of gut microbiota in the prevention and treatment of CRC in the near future and thus reduce the incidence of CRC.

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Anti-tumor activity of polysaccharides extracted fromPinus massonianapollen in colorectal cancer-in vitroandin vivostudies

Abstract: The prevalence and mortality rate of colorectal cancer (CRC) have been dramatically rising worldwide. Pinus massoniana pollen, a well-known natural nutrition food, is one of the most commonly consumed traditional...

Cited by 10 publications

References 32 publications

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Comparison study of protective effects of porcine bile acids and sheep bile acids against heat stress in chickens

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

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