Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis

Liu, Qiong; Chen, Lingying; Yin, Wang; Nie, Yuehua; Zeng, Peng-Hui; Yang, Xin

doi:10.1080/15384101.2021.1995684

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…Cell cycle arrest is a potential way to treat tumors [33]. Previous studies have found that drug treatment can induce cell cycle arrest in breast, liver and lung cancers [34][35][36]. In this study, ITF2357 (1.842 µg/mL) induced cell cycle arrest in IOMM cells at G0/ G1 and G2/ M stages.…”

Section: Discussionmentioning

confidence: 60%

ITF2357 Induces Cell Cycle Arrest and Apoptosis in Meningioma Cells

Zhang

Aizezi

et al. 2022

Preprint

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As a type of central nervous system tumor, meningioma usually compresses the nerve center due to its local expansion, further causing neurological deficits. However, there are limited therapeutic approaches for meningiomas. ITF2357, a potent class I and II histone deacetylase inhibitor (HDACi), has been shown to inhibit cell proliferation, promote apoptosis and block the cell cycle in a variety of sarcoma cells, including glioblastoma and peripheral T-cell lymphoma. Here, we investigated the antitumor potential of ITF2357 on meningioma cells (IOMM). First, we demonstrated that the half-maximal inhibitory concentration (IC50) of ITF2357 was 1.842 µg/ml by MTT assay. In addition, ITF2357 effectively inhibited the proliferation and colonization ability of IOMM cells. Flow cytometry analysis showed that ITF2357 induced G0/G1 cell cycle arrest and cell apoptosis. Mechanically, the RNA sequencing data revealed that ITF2357 could affect the PI3K-Akt signaling pathway and the cell cycle progression. Furthermore, the expression level of cyclin B1, cyclin D1, and CDK1 was determined by western blotting. Collectively, our data revealed that ITF2357 inhibited cell viability and proliferation of meningioma cells by inducing G0/G1 phase arrest and apoptosis, and inhibiting cell cycle-related proteins (CDK/cyclin B1/cyclin D1), which developed a new approach to the treatment of meningioma.

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Section: Discussionmentioning

confidence: 60%

ITF2357 Induces Cell Cycle Arrest and Apoptosis in Meningioma Cells

Zhang

Aizezi

et al. 2022

Preprint

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“…Human breast carcinoma (MCF-7) cells were suppressed dramatically by 4′′′-O-Methylamentoflavone 4 with ED 50 of 4.56–16.24 μg/mL, further bringing cell apoptosis [ 15 ]. Likewise, ginkgetin 6 showed the inhibition effect on hepatocellular cancer cell line (HepG2) cells at 50.0 μmol/mL, leading to the decline of cell viability, cell numbers, and morphological changes [ 29 ]. Isoginkgetin 9 at from 2.5 to 20 μmol/L was reported to have an apparent inhibitory effect on A549 lung cancer cells via upregulating the expression of miR-27a-5p and downregulating the level of apurinic/apyrimidinic endo-deoxyribonuclease 1 (APEX1) [ 34 ], and sotetsuflavone 11 at 200 mmol/L showed the same inhibition of A549 cells but with relation to increased E-cadherin and decreased N-cadherin [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Flavonoid Components, Distribution, and Biological Activities in Taxus: A review

Wei

2023

Molecules

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Taxus, also known as “gold in plants” because of the famous agents with emphases on Taxol and Docetaxel, is a genus of the family Taxaceae, distributed almost around the world. The plants hold an important place in traditional medicine in China, and its products are used for treating treat dysuria, swelling and pain, diabetes, and irregular menstruation in women. In order to make a further study and better application of Taxus plants for the future, cited references from between 1958 and 2022 were collected from the Web of Science, the China National Knowledge Internet (CNKI), SciFinder, and Google Scholar, and the chemical structures, distribution, and bioactivity of flavonoids identified from Taxus samples were summed up in the research. So far, 59 flavonoids in total with different skeletons were identified from Taxus plants, presenting special characteristics of compound distribution. These compounds have been reported to display significant antibacterial, antiaging, anti-Alzheimer’s, antidiabetes, anticancer, antidepressant, antileishmaniasis, anti-inflammatory, antinociceptive and antiallergic, antivirus, antilipase, neuronal protective, and hepatic-protective activities, as well as promotion of melanogenesis. Flavonoids represent a good example of the utilization of the Taxus species. In the future, further pharmacological and clinical experiments for flavonoids could be accomplished to promote the preparation of relative drugs.

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“…Ginkgetin (GK) is a natural biflavone with anticancer, antiinflammatory, antimicrobial, anti-adipogenic, and neuroprotective activities (Adnan et al, 2020). GK has anticancer activities in a wide range of cancer types including lung cancer (Lou et al, 2017;Ho et al, 2018;Liu et al, 2022;Wu et al, 2023). In EGFR wild-type Mechanisms of ferroptosis-inducing small-molecule compounds that may boost the anti-tumor activity of chemotherapeutic agents or overcome chemotherapy drug resistance in lung cancer.…”

Section: Reversing Chemotherapeutic Resistance In Lung Cancer-inducin...mentioning

confidence: 99%

Inducing ferroptosis by traditional medicines: a novel approach to reverse chemoresistance in lung cancer

Wang,

Hu,

Fleishman

et al. 2024

Front. Pharmacol.

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Lung cancer is the leading cause of global cancer-related deaths. Platinum-based chemotherapy is the first-line treatment for the most common type of lung cancer, i.e., non-small-cell lung cancer (NSCLC), but its therapeutic efficiency is limited by chemotherapeutic resistance. Therefore, it is vital to develop effective therapeutic modalities that bypass the common molecular mechanisms associated with chemotherapeutic resistance. Ferroptosis is a form of non-apoptotic regulated cell death characterized by iron-dependent lipid peroxidation (LPO). Ferroptosis is crucial for the proper therapeutic efficacy of lung cancer-associated chemotherapies. If targeted as a novel therapeutic mechanism, ferroptosis modulators present new opportunities for increasing the therapeutic efficacy of lung cancer chemotherapy. Emerging studies have revealed that the pharmacological induction of ferroptosis using natural compounds boosts the efficacy of chemotherapy in lung cancer or drug-resistant cancer. In this review, we first discuss chemotherapeutic resistance (or chemoresistance) in lung cancer and introduce the core mechanisms behind ferroptosis. Then, we comprehensively summarize the small-molecule compounds sourced from traditional medicines that may boost the anti-tumor activity of current chemotherapeutic agents and overcome chemotherapeutic resistance in NSCLC. Cumulatively, we suggest that traditional medicines with ferroptosis-related anticancer activity could serve as a starting point to overcome chemotherapeutic resistance in NSCLC by inducing ferroptosis, highlighting new potential therapeutic regimens used to overcome chemoresistance in NSCLC.

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Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis

Cited by 16 publications

References 40 publications

ITF2357 Induces Cell Cycle Arrest and Apoptosis in Meningioma Cells

ITF2357 Induces Cell Cycle Arrest and Apoptosis in Meningioma Cells

Flavonoid Components, Distribution, and Biological Activities in Taxus: A review

Inducing ferroptosis by traditional medicines: a novel approach to reverse chemoresistance in lung cancer

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