Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review

Wu, Jing; Xue, Xindong; Wu, Zhen; Zhao, Hengli; Cao, Hongmei; Sun, Deqing; Wang, Rong-Mei; Sun, Jing; Liu, Ying; Guo, Rongbo

doi:10.1016/j.bionut.2013.08.002

Cited by 10 publications

(9 citation statements)

References 92 publications

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“…Paeonol can inhibit apoptosis in human cancer and has a synergistic effect by regulating the signalling pathways, including NF-κB, PI3K/PTEN/AKT and ERK/JNK/P38/MAPKs activations11. However, it is still unclear why non-cancer cells can survive the mechanism.…”

Section: Resultsmentioning

confidence: 99%

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Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Jiao

Sun

Guo

et al. 2016

Sci Rep

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Polydimethylsiloxane (PDMS) is widely used as a cell culture platform to produce micro- and nano-technology based microdevices. However, the native PDMS surface is not suitable for cell adhesion and is always subject to bacterial pollution and cancer cell invasion. Coating the PDMS surface with antibacterial or anticancer materials often causes considerable harm to the non-cancer mammalian cells on it. We have developed a method to fabricate a biocompatible PDMS surface which not only promotes non-cancer mammalian cell growth but also has antibacterial and anticancer activities, by coating the PDMS surface with a Chinese herb extract, paeonol. Coating changes the wettability and the elemental composition of the PDMS surface. Molecular dynamic simulation indicates that the absorption of paeonol onto the PDMS surface is an energy favourable process. The paeonol-coated PDMS surface exhibits good antibacterial activity against both Gram-positive and Gram-negative bacteria. Moreover considerable antibacterial activity is maintained after the coated surface is rinsed or incubated in water. The coated PDMS surface inhibits bacterial growth on the contact surface and promotes non-cancer mammalian cell growth with low cell toxicity; meanwhile the growth of cancer cells is significantly inhibited. Our study will potentially guide PDMS surface modification approaches to produce biomedical devices.

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Section: Resultsmentioning

confidence: 99%

“…Paeonol in solution is reported to exhibit considerable antibacterial and anticancer activities. The antibacterial effect results from paeonol’s ability to inhibit the α-glucosidase activity of bacteria and then induce cell death1011. Paeonol inhibits the proliferation of tumor cell lines, such as T6-17, HeLa and HT-2912.…”

mentioning

confidence: 99%

Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Jiao

Sun

Guo

et al. 2016

Sci Rep

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“…Exogenous stimuli can activate the NF-jB signalling pathway, leading to activation of IjB kinase. This results in the phosphorylation of IjB protein, causing the degradation of IjB protein, and then releasing NF-jB (Wu et al 2014). Upon activation via posttranslational modifications, NF-jB is transferred to the nucleus, where it promotes the transcription of the target genes.…”

Section: Discussionmentioning

confidence: 99%

“…Normally, NF-jB binds to the inhibitor of nuclear factor kappa-B (IjB) protein to form a complex that blocks the nuclear localization signal of NF-jB. However, when the cells are stimulated by alcohol, IjB protein is phosphorylated by the activated IjB kinase and then the nuclear localization signal of NF-jB is exposed and NF-jB is transported into the nucleus (Wu et al 2014). The inhibition of NF-jB activation and cytokine synthesis is a potential mechanism for the treatment of alcohol-induced liver injury (Abhilash et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Boletus aereus protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway

Zhang

Meng

et al. 2020

Pharmaceutical Biology

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“…MAPK signaling pathways are known to influence the modulation of the inflammatory response and cellular processes (47). Three MAPK family members have been identified in mammalian cells, including ERK1/2, JNK and p38/MAPK (48).…”

Section: Discussionmentioning

confidence: 99%

Dysifragilone A inhibits LPS‑induced RAW264.7 macrophage activation by blocking the p38 MAPK signaling pathway

Zhang

Jin

et al. 2017

Mol Med Report

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Dysifragilone A, a sesquiterpene aminoquinone based on a rearranged avarone skeleton, has been previously isolated and identified from the South China Sea sponge Dysidea fragilis. In the present study, anti‑inflammatory activity and the underlying molecular mechanism of dysifragilone A were studied using the classical inflammation model of lipopolysaccharide (LPS)‑activated RAW264.7 macrophage cells and an MTT assay, Griess method, ELISA and western blotting were used. The results revealed that dysifragilone A significantly reduced the release of inflammatory mediators and inflammatory cytokines in activated RAW264.7 cells, including nitric oxide (NO), prostaglandin E2,(PGE2) and interleukin‑6 (IL‑6). The protein expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase‑2 (COX‑2), and the enzymatic activity of iNOS and COX‑2 were also inhibited by dysifragilone A in a dose dependent manner. Further mechanistic investigations suggested that the anti‑inflammatory activity of dysifragilone A results from the suppression of p38 mitogen‑activated protein kinase (MAPK) activation in LPS‑activated macrophages; however, this was not associated with inhibition of the extracellular signal‑regulated kinase (ERK) or c‑Jun N‑terminal kinase (JNK) signaling pathways. Therefore, dysifragilone A and similar compounds may be anti‑inflammatories that have potential to be used in the clinic.

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Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review

Cited by 10 publications

References 92 publications

Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Boletus aereus protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway

Dysifragilone A inhibits LPS‑induced RAW264.7 macrophage activation by blocking the p38 MAPK signaling pathway

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