Anti-Tussive Effect and Gross Toxicities of Methanol Extract of Mucuna Pruriens (L) Dc in Comparison of Codeine Phosphate

Abstract

The aim of the current study is to evaluation of plant seed extract of Mucuna pruriens for its gross toxicities and antitussive activity. Anti-tussive effect was observed by inducing cough using sulfur dioxide gas and counts the number of cough before and after administration of extract and centrally acting cough suppressant (codeine phosphate) given orally. Mucuna pruriens seed extract showed highly significant antitussive effect (**p<0.005) and compare to control and reference drug codeine phosphate and may act on opioid receptor that may located in airway passage and produces inhibitory effect. The results suggest that Mucuna pruriens seed may contains cough protective agent and have potential therapeutic value.