Visible Light Mediated Organophotoredox-Catalyzed One-Pot Domino Synthesis of Novel 6,7 Disubstituted 1H-Pyrroles

Govindaraju, Santhosh; Tabassum, Sumaiya

doi:10.1007/s11244-022-01580-y

Cited by 10 publications

(8 citation statements)

References 47 publications

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“…18 They are an essential part of the principles of green chemistry, which aim to make chemical processes more sustainable. 19,20 Water is the most abundant and environmentally friendly solvent, and water is becoming increasingly used in organic synthesis due to advances in reaction design. 21 Ionic liquid salts are in liquid form and have unique properties such as high thermal stability, negligible vapor pressure, and tuneable polarity.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

Servesh,

Lokesh Kumar,

Govindaraju

et al. 2024

Polymers for Advanced Techs

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Reactant solubility, which dictates achievable concentrations, and the stability of reaction intermediates (excited states), solvents modulate the potential energy landscape and influence reaction rates. Consequently, solvent selection is pivotal in optimizing process productivity, economic feasibility, and environmental footprint. At present, organic synthesis pivots around the idea of sustainability. In particular, PEG‐400, a popular solvent and phase transfer catalyst, is considered greener as it can be reused several times without significant loss in its catalytic activity, which checks the box regarding sustainability. This review highlights the emerging potential of Polyethylene Glycol 400 (PEG‐400) as a dual‐threat agent in sustainable organic synthesis. We explore its efficacy as a catalyst, promoting various reactions under mild conditions and often eliminating the need for traditional metal catalysts. Additionally, PEG‐400's role as a green solvent is addressed, emphasizing its biodegradability, low toxicity, and ability to facilitate reactions without hazardous Volatile Organic Compounds (VOCs). The review examines recent research on PEG‐400 mediated reactions, showcasing its effectiveness in diverse transformations, thus exploring the potential of PEG 400 as a facilitator for heterocycle synthesis in both multicomponent reactions and stepwise approaches. It identifies exciting research directions that promise to expand the boundaries of polymer‐based solvents in heterocyclic chemistry.

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Section: Introductionmentioning

confidence: 99%

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

Servesh,

Lokesh Kumar,

Govindaraju

et al. 2024

Polymers for Advanced Techs

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“…[6,7] Considering the pros, MCRs have the upper hand and hence can be a suitable solution in organic synthesis. [8][9][10][11] However, one of the prominent cons of MCR is the solvent requirement. [12,13] The most common volatile organic compounds used in organic transformation are petrochemical analogues with lower molecular masses, which have inherent problems such as high flammability, volatility, non-biodegradability, and toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…MCR methodology is highly atom efficient and environmentally favorable, which results in an incredible degree of complex molecules with diversity in product formation [6,7] . Considering the pros, MCRs have the upper hand and hence can be a suitable solution in organic synthesis [8–11] . However, one of the prominent cons of MCR is the solvent requirement [12,13] .…”

Section: Introductionmentioning

confidence: 99%

A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles

Servesh

Sriwastav

et al. 2023

ChemistrySelect

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Multicomponent reactions are crucial for operating organic synthesis. In today's world, chemists concentrate on greener methodologies that cater to rising environmental concerns. Most conventional organic solvents are harsh on the environment, which can be addressed by environmentally and pocket‐friendly Deep eutectic solvents (DES). Organic synthesis via MCR in the presence of DES has resulted in the blend of green methodology and green solvent for organic transformations. Forasmuch as addressing the environmental concerns and developing higher heterocycles, our review focuses on the literature published on the DES‐mediated Multicomponent synthesis of N‐Heterocyclic compounds.

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“…[39] Ketorolac, sold under Toradol is another NSAID used for short-term management of moderate to severe pain. [40] This review offers a comprehensive description of the structure, synthesis, properties, and applications of pyrroles over the last 20 years, as well as the relevant SAR investigations that have been carried out.…”

Section: Introductionmentioning

confidence: 99%

“…It is known for its controversial registration as a pesticide due to its environmental impact and toxicity to humans and wildlife, especially birds [39] . Ketorolac, sold under Toradol is another NSAID used for short‐term management of moderate to severe pain [40] …”

Section: Introductionmentioning

confidence: 99%

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

Ganesh,

Raj,

Aruchamy

et al. 2023

ChemMedChem

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An overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of pyrrole derivatives for drug development are provided in this article. It lists instances of naturally occurring pyrrole‐containing compounds and describes the sources of pyrroles in nature, including plants and microbes. It also explains the many conventional and modern synthetic methods used to produce pyrroles. The key topics are the biological characteristics, pharmacological behavior, and functional alterations displayed by pyrrole derivatives. It also details how pyrroles are used to treat infectious diseases. It describes infectious disorders resistant to standard treatments and discusses the function of compounds containing pyrroles in combating infectious diseases. Furthermore, the review covers the uses of pyrrole derivatives in treating non‐infectious diseases and resistance mechanisms in non‐infectious illnesses like cancer, diabetes, and Alzheimer's and Parkinson's diseases. The important discoveries and probable avenues for pyrrole research are finally summarized, along with their significance for medicinal chemists and drug development. A reference from the last two decades is included in this review.

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Visible Light Mediated Organophotoredox-Catalyzed One-Pot Domino Synthesis of Novel 6,7 Disubstituted 1H-Pyrroles

Cited by 10 publications

References 47 publications

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

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