Anti-ulcer activity of ethanol extract of Terminalia pallida Brandis. in Swiss albino rats

Gupta, Malaya; Mazumder, Upal Kanti; Manikandan, L. C.; Bhattacharya, Sangita; Senthilkumar, Gandhipuram Periyasamy; Suresh, R.

doi:10.1016/j.jep.2004.10.017

Cited by 31 publications

(21 citation statements)

References 13 publications

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“…JGLE, aspirin and standard antiulcer drug, famotidine (Dharmani et al, 2005;Gupta et al, 2005) were prepared in 0.5% sodium carboxy methyl cellulose (CMC) suspension as vehicle and administered orally once daily at a volume of 10 ml/kg body weight. The animals were divided into four groups, consisting of six each.…”

Section: Aspirin + Pylorus Ligation-induced Ulcer Modelmentioning

confidence: 99%

Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

Umamaheswari

Asokkumar

Rathidevi

et al. 2007

Journal of Ethnopharmacology

110

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Section: Aspirin + Pylorus Ligation-induced Ulcer Modelmentioning

confidence: 99%

Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

Umamaheswari

Asokkumar

Rathidevi

et al. 2007

Journal of Ethnopharmacology

110

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“…In a study on Swiss albino rats, Gupta et al (31) reported that the ethanol extract of Terminalia pallida Brandis (EETP) fruit had antiulcer activity against drug-, histamine-, and ethanol-induced ulcers. The researchers concluded that the extract reduced mucosal damage by increasing the antioxidant potential of the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Study of Hydroalcoholic Extract of Terminalia catappa Leaves in Treatment of Indomethacin-Induced Gastric Ulcer in Rats

Arzi

Karampour

Rezaei

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Traditional medicine discussed in the literature introduced Terminalia catappa (TC) L. as an antiulcer plant. Objectives: In this study, we investigated the activity of hydroalcoholic extract from TC leaves against indomethacin-induced gastric ulcers in rats. Methods: Animals were divided into 13 groups, each consisting of six rats. The rats fasted for 48 hours. Various doses of Terminalia catappa leaf extract (TCLE) (100, 200, 400, and 600 mg/kg), ranitidine (50 mg/kg), and normal saline (5 mL/kg) were administered orally to the assigned group of rats. Indomethacin (30 mg/kg) was administered to all six groups before treatment. Other groups received only TCLE (100, 200, 400, and 600 mg/kg), ranitidine (50 mg/kg), CMC (1% solution), or indomethacin. Five hours after the drugs were administered, the animals' stomachs were opened through the large curvature and lesions were observed. One-way ANOVA and LSD tests were used for data analysis, and the minimum significance level was P < 0.05. Results:The results showed that all doses of TCLE and ranitidine had a significant effect (P > 0.05) against the gastric damage caused by indomethacin. There was no significant difference (P > 0.05) between TCLE (400 mg/kg) and ranitidine. Conclusions: The flavonoids, saponins, tannins, alkaloids, and antioxidant properties of TCLE can decrease some of the effects of an indomethacin-induced gastric ulcer.

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“…Vehicle control, EMA in doses 200 and 400 mg/kg and ranitidine 50 mg/kg were administered orally for 7 days in their respective groups on the eighth day, experiment was performed by the standard method with some modifications as described by Gupta et al 28 . Briefly, wistar albino rats were fasted for 18 hrs and deprived of water for 12 hrs.…”

Section: Indomethacin Induced Ulcermentioning

confidence: 99%

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2015

IJPSR

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Context:The leaves Morus alba have been traditionally used in Asian countries for treatment of different ailments. Objective: Present study was undertaken to evaluate the effect of ethanol extract from Morus alba leaves supplementation on gastric tissue glutathione level in indomethacin induced ulcers in rats. Materials and Methods: Ethanol extract from Morus alba leaves was administered at the doses 200 and 400 mg/kg/day, p.o. for seven days. Ulceration was induced by giving indomethacin. Ulcer index, gastric GSH level, gastric wall mucus level was estimated. The functioning of liver was also assayed. Results: The effects ethanol extract from Morus alba leaves were significant and comparable to reference treated group of rats. The gastric GSH levels were replenished by Morus alba leaves in 400 mg/kg. Conclusion: From this study it was concluded that ethanol extract from Morus alba leaves possess significant ulcer protection by replenishing gastric GSH and increasing gastric mucus level.

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Anti-ulcer activity of ethanol extract of Terminalia pallida Brandis. in Swiss albino rats

Cited by 31 publications

References 13 publications

Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

Histopathological Study of Hydroalcoholic Extract of Terminalia catappa Leaves in Treatment of Indomethacin-Induced Gastric Ulcer in Rats

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