Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Savaringal, Jayan Pariyani; Sanalkumar, K B

doi:10.5455/njppp.2018.8.1249201012018

Cited by 3 publications

(3 citation statements)

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“…23 In albino rats, the C. longa ethanolic extract (250, 500, and 1000 mg/kg) prevented edema and showed antiinflammatory activity of 1000 mg/kg dose comparable to the effect of aspirin. 44 In the CIA of the ankle joints in rats, C. longa (30,60, and 110 mg/kg) decreased arthritic score dose-dependently along with a significant effect on the reduction of erythema. The bone erosion was controlled, and osteophyte formation did not occur by C. longa at doses of 60 and 110 mg/kg.…”

Section: Anti-inflammatory Effects Of C Longa and Its Constituent Curcuminmentioning

confidence: 95%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional medicine, especially for treating inflammatory conditions C. longa and its main constituent, curcumin (CUR), showed various pharmacological effects such as antioxidant and anti-microbial properties. The updated knowledge of anti-inflammatory, antioxidant, and immunomodulatory effects of C. longa and CUR is provided in this review article. Pharmacological effects of C. longa, and CUR, including anti-inflammatory, antioxidant, and immunomodulatory properties, were searched using various databases and appropriate keywords until September 2020. Various studies showed anti-inflammatory effects of C. longa and CUR, including decreased white blood cell, neutrophil, and eosinophil numbers, and its protective effects on serum levels of inflammatory mediators such as phospholipase A2 and total protein in different inflammatory disorders. The antioxidant effects of C. longa and CUR were also reported in several studies. The plant extracts and CUR decreased

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Section: Anti-inflammatory Effects Of C Longa and Its Constituent Curcuminmentioning

confidence: 95%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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“…Inflammatory cell infiltration in the lamina propria and submucosa of aspirin-induced ulcer might be related to loss of integrity of the intercellular junctions, disturbance of the protective mucus barrier and generation of reactive oxygen species (ROS) with subsequent bacterial invasion which leads to excessive leukocyte infiltration inside the gastric epithelial linings by the activation of interleukin pathway [55,56] .…”

Section: Discussionmentioning

confidence: 99%

Trio-clar Versus Portulaca Oleracea and/or Foeniculum Vulgare Extracts on Induced Gastric Ulcer in Adult Female Albino Rats. A Histological Study

Ahmed¹,

Abd-Elgwwad

Hasan

et al. 2020

Egyptian Journal of Histology

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Introduction: Gastric ulcer is a complex disease affecting the stomach. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the most common cause of gastric ulcers. Drugs used in gastric treatment induce side effects and drug interactions. Portulaca oleracea L. (purslane), Foeniculum Vulgare Mill (Fennel) are herbal remedies having gastro-protective effects. Aim of work: To assess the cytoprotective effects of trio-clar versus fennel and ∕or purslane on aspirin-induced gastric ulcer in adult female albino rats. Materials and Methods: Forty-two adult female albino rats were divided into three main groups. Group I (control group). Group II (gastric ulcer), overnight fasted rats received aspirin solution (300 mg/kg/day) orally by gastric tube. GroupIIIincorporated as the treated gastric ulcer group that was subdivided equally into four subgroups. GIIIa: gastric ulcer treated with Trio-clar. GIIIb: gastric ulcer treated with purslane extract at dose 750 mg ∕ kg. GIIIc: gastric ulcer treated with fennel extract at a dose of 300 mg ∕ kg. GIIId: gastric ulcer treated with a combined dose of purslane and fennel extract. Fundus of stomach specimens was prepared and examined using different histological techniques. Results: Light microscopic study of the gastric ulcer group depicted severe mucosal injury in the form of ulcerative erosion, dilated distorted glandular architecture, damage of parietal and chief cells with vacuolated cytoplasm and pyknotic nuclei, congested blood vessels and inflammatory cellular infiltration. A reduction of combined Alcian blue and Periodic-Acid-Schiff reaction coupled to a significant increase in area percentage of collagen fibers observed upon aspirin administration. The ultrastructural assessment confirmed these distortions. The treated groups showed different degrees of improvement in the histological changes depicted previously with priority to the combined administration of purslane and fennel extracts. Conclusion: Combined administration of purslane and fennel was more effective in enhancing the healing process than either purslane, fennel alone or trio-clar drug.

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“…Since there are contradicting reports on the safety of consuming turmeric powder in large quantity and the exact concentration of turmeric rhizome powder in diet that could have deleterious effect has not been popularly documented, it is very important therefore to elucidate those contradicting reports [12]. It is also essential to obtain additional scientific proof to justify that the consumption of TRP could enhance gastric mucosa, hepatic and renal preservation.…”

Section: Introductionmentioning

confidence: 99%

Effects of Turmeric Rhizome Powder Supplemented Diet on Indomethacin-induced Toxicity in Wistar Rats

Oluwafemi

Ajayi

Oseni

et al. 2021

AJBGMB

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Turmeric (Curcuma longa) L rhizome powder (TRP) was commonly reported to have antiulcerogenic and non-toxicity effects. However, the scientific evidence showing the effectiveness of turmeric in the treatment of gastric ulcer and its non-toxicity effect are controversial. The aim of the study was to investigate the effects of different percentages of turmeric rhizome powder supplemented diet on toxicity induced by indomethacin in Wistar rats. This study investigated the effects of TRP formulated diet on the activities of blood enzymes in indomethacin-induced gastric ulcerated Wistar rats. This investigation was carried out through a 28-day experiment using corn-starch flour meal-based diet containing four levels of TRP (1%, 2%, 5% and 10%) as treatments with five replicates in a completely randomized design. The remaining three groups were fed with basal diet, one group received standard drug, another received no treatment but induced while the last group received no treatment and not induced. 35 male Wistar rats weighing 150-200 g were housed in seven cages and received feed and water ad-libitum. At the end of the experiment, all the animals were sacrificed, blood and some organs were collected and evaluated for hepatoxicity and nephrotoxicity induced by indomethacin (60mg/kg bw). Measurements of serum, kidney and liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were performed. Statistical evaluation of the results at a p < 0.05 showed significantly elevated values (P ≤ 0.05) of these enzymes in the kidney of rats in groups B, C, E and G when compared with group F. Increase in kidney ALT and AST activities of animals in groups A, C and D was detected in comparison with group F. Furthermore, there was increase in hepatic ALT and ALP activities of animals in groups A, B, C, D and E compared with animals in group F but a significant increase (P ≤ 0.05) in group G in comparison with group F. Likewise, there was significant increase (P ≤ 0.05) in liver AST activities of rats in groups A, B, C, E and G compared with group F, however, insignificant increase (P ≤ 0.05) was observed in animals in group D in comparison with rats in group F. Indomethacin induced rats (group F) showed a significant increase in serum levels of ALT, AST and ALP compared with rats in groups E and G in all the groups but those fed on 1%, 2%, 5% and 10% turmeric supplemented diet showed decrease in comparison with group F. The increased levels of these enzymes in the serum of animals in ulcerogenic group and some in group D (10%TRP group) could be a sign of tissue injury due to relative toxicity of indomethacin induction in animal model and deleterious effect of turmeric rhizome powder at large concentration. However, decrease levels of these enzymes in pretreated groups could indicate the attenuating potential of turmeric at moderate dose against toxicity effect of indomethacin induction. Therefore, turmeric rhizome powder should be consumed with caution and its percentage in the whole recipe should not be up to 10% (100g/kg).

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Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Cited by 3 publications

References 20 publications

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

Trio-clar Versus Portulaca Oleracea and/or Foeniculum Vulgare Extracts on Induced Gastric Ulcer in Adult Female Albino Rats. A Histological Study

Effects of Turmeric Rhizome Powder Supplemented Diet on Indomethacin-induced Toxicity in Wistar Rats

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