Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism

Li, Weifeng; Wang, Xiumei; Zhang, Hailin; He, Zehong; Zhi, Wenbing; Liu, Fang; Wang, Yu; Niu, Xiaofeng

doi:10.1016/j.intimp.2016.06.016

Cited by 56 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in accordance with El‐Komy and Mouafi (), who reported that TNF‐α production was increased in oxidative damages induced by indomethacin. TNF‐α is an aggressive factor known to participate in the pathogenesis of gastric mucosa through stimulating neutrophil infiltration (El‐Ashmawy, Khedr, El‐Bahrawy, & Selim, ) and nuclear factor kappa B (NF‐kB) production (Li, Wang et al, ). Moreover, TNF‐α plays a major role in the activation of caspases which are important in the induction of cell apoptosis (Li, Hao et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…PGE2 is a fundamental molecule which modulates the integrity of the gastric mucosa by controlling gastric acid secretion, improving mucus and bicarbonates secretion (Sidahmed et al, ), accelerating mucosal blood flow (Li, Wang et al, ), inhibiting TNF‐α production (El‐Ashmawy et al, ), and enhancing the epithelial cells resistance to cytotoxins (Alrashdi et al, ). PGE2, after oral administration of diclofenac sodium, decreased significantly in the control group as compared to the negative control group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

View full text Add to dashboard Cite

This study was designed to investigate the antioxidant and antiulcer activities of flavonoid‐rich fractions of Zingiber officinale extract. The fractions, obtained by solvents of increasing polarities, were subjected to 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity. The fraction which possessed the highest antioxidant activity was used to assess gastroprotective action against diclofenac sodium induced gastric ulcer in rats. Chromatographic profiling was carried out using LC‐ESI‐MS analysis. The butanol fraction (BF) showed the strongest antioxidant potential and the results of the in vivo study revealed that BF at 100 mg/kg protected against gastric lesions. At the same dose, BF prevented diclofenac sodium‐induced increase in tumor necrosis factor alpha (TNF‐α) and malondialdehyde (MDA) levels, and depletion of catalase (CAT) activity as well as glutathione (GSH) and prostaglandin E2 (PGE2) contents. LC‐ESI‐MS analysis revealed the presence of 12 phenolic compounds. BF exerted antiulcer action which could be linked to the presence of phenolic compounds. Practical applications Zingiber officinale has been widely consumed as a spice and used in folk medicine for treatment of gastric disorders. This is the first report evaluating the pharmacological effects of the butanol extract of ginger for the prevention of gastric ulcer. The results showed that the extract affords better gastroprotective activity against diclofenac sodium‐induced gastric ulcer in rats by reducing oxidative stress. Information provided in this study will be beneficial for developing applications of ginger in food biotechnology as functional and nutraceutical ingredient.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Ethanol‐induced gastric mucosal injury in mice has been used extensively for the evaluation of anti‐ulcerative effects in a wide range of potential agents as it is similar to human with gastric ulcer. Ethanol could damage the gastric mucosa leading to severe macroscopical injuries within a short time, which was characterized by erythema, bleeding, and lesions (Kenjirou, Atsushi, Junji, Saori, & Hideaki, ; Li et al, ). These alterations were in agreement with our study.…”

Section: Discussionmentioning

confidence: 99%

“…Drug was given by intragastric administration once a day for three consecutive days. Mice in the normal control group and the ethanol control group (negative control) received saline at a dose of 2.5 ml/kg; Mice in the cimetidine control group (positive control) received cimetidine at a dose of 100 mg/kg according to a previous report (Li et al, ); mice in three gentiopicroside investigative groups received different doses of gentiopicroside (20, 40, and 80 mg/kg), respectively; On the third day, except that mice in the normal control group received saline, mice in other groups received 70% ethanol at a dose of 0.01 ml/g by oral 1 hr after the last intragastric administration. One hour after the induction, animals were euthanized under anesthesia by cervical dislocation, removed and cut the stomach longitudinally.…”

Section: Methodsmentioning

confidence: 99%

Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol‐induced gastric mucosal injury in mice

Yang

Wang

Zhang

et al. 2017

Phytotherapy Research

View full text Add to dashboard Cite

Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol-induced gastric mucosal injury in mice. Mice were proactively administrated with gentiopicroside by intragastric administration once a day for 3 consecutive days. On the 3rd day, gastric ulcer in mice was induced with 70% ethanol after the last intragastric administration. The stomach tissues were submitted for evaluation of the severity of gastric mucosal alterations. Gentiopicroside administrated orally ameliorated the severity of gastric mucosal alterations. Oral administration of gentiopicroside significantly increased heat shock protein-70 and glutathione levels and superoxide dismutase activity, normalized epidermal growth factor and vascular endothelial growth factor levels, and decreased the levels of tumour necrosis factor-α, interleukin-6 and malondialdehyde, and myeloperoxidase activity in gastric tissue. These findings demonstrated that gentiopicroside has protective effect against ethanol-induced gastric mucosal injury in mice through the improvements of antioxidative and anti-inflammatory effects, as well as up-regulation of heat shock protein-70 level and normalization of epidermal growth factor and vascular endothelial growth factor levels. The results presented in this study provide some evidence for the development of a novel antigastric ulcer agent.

show abstract

“…Chronic gastric ulcer is closely associated with smoking, bacteria infection, irregular eating habits, chronic bile reflux, autoimmune disorders and stress, whereas acute gastric ulcer is usually caused by excessive consumption of alcohol or high dose of non-steroidal anti-inflammatory drugs (NSAIDs). [1][2][3][4][5][6] High concentration of alcohol (>40%, v/v) and overconsumption of alcoholic beverages can lead to acute gastric ulcers characterized by powerful oxidative stress. [1][2][3][4][6][7][8] Selenium (Se) is an indispensable trace element required for most of the living organisms including animals and human beings.…”

Section: Introductionmentioning

confidence: 99%

<p>Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles</p>

Bai¹,

Hong²,

Tan³

et al. 2020

IJN

View full text Add to dashboard Cite

Background: Selenium (Se) is an indispensable trace element required for animals and human beings, whereas Se-deficiency can accelerate the development of acute gastric injury induced by over-consumption of alcohol. Selenium nanoparticles (SeNPs), as a special Sesupplement with favorable properties and unique bioactivities, are expected to play a passive role in gastroprotection. To the best of our knowledge, the gastroprotective potential of SeNPs is unknown and also, a rapid preparation of orally stable SeNPs available for prospective commercial application in the clinic is needed. Thus, SeNPs-embedded chitosan microspheres (SeNPs-CM) were developed to deliver SeNPs, and their gastroprotective potential was evaluated. Results: Herein, a rapid, eco-friendly and economic preparation process, composed of synthesis of SeNPs decorated by chitosan (CS), purification of CS-SeNPs by ultra-filtration (UF) and spray-drying of the purified CS-SeNPs, was introduced to prepare SeNPs-CM. The uniformly distributed SeNPs with a nanosize range of 60 nm were loaded into CSmicrospheres, and they could be released from the microspheres in gastric conditions. In addition, SeNPs-CM were safer than selenite in terms of Se dose, with a LD 50 of around 8-fold of that of selenite, and it could efficiently enhance the Se retention in Se-deficient Wistar rats. Furthermore, SeNPs-CM pre-treatment might significantly attenuate the ethanolinduced gastric mucosal damage, based on histological evaluation. It might be partly attributed to the systematic antioxidant activities of SeNPs-CM, reflected by the reduction in lipid peroxidation, the augmentation in antioxidant enzymatic activity as well as decreasing aggressive nitric oxides (NO). Conclusion: SeNPs-CM could be taken into consideration as a prospective Se-supplement for the oral delivery of SeNPs, with prominent gastroprotective effect against ethanolinduced mucosal injury.

show abstract

Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism

Cited by 56 publications

References 42 publications

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol‐induced gastric mucosal injury in mice

<p>Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles</p>

Contact Info

Product

Resources

About