Anti-ulcerogenic effect of Zuojin Pill against ethanol-induced acute gastric lesion in animal models

Wang, Jing; Zhang, Tianzhu; Zhu, Lingpeng; Ma, Chi; Wang, Shumin

doi:10.1016/j.jep.2015.04.017

Cited by 43 publications

(27 citation statements)

References 20 publications

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“…Previous findings implicated that the productions of pro-inflammatory cytokines IL-6 and TNF-α remarkably increased in the serum and gastric tissue of the ethanol-induced ulcer [25]. As a representative inflammatory cytokine with pleiotropic functions, TNF-α is closely associated with the progression of inflammatory disorder [26]. Previous research showed an aberrant high level of IL-6 in the serum of mice with inflammatory diseases including severe mucosal inflammation [27].…”

Section: Discussionmentioning

confidence: 99%

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao

Gong

Wang

et al. 2015

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao

Gong

Wang

et al. 2015

International Immunopharmacology

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“…ZJP has a wide range of pharmacological action in digestive system, including bacteriostasis, antiin ammatory and analgesic effects. Studies show that the protection offer by the ZJP against ethanolinduced mucosal lesions is indicative of its outstanding gastroprotective effect, which may be related to regulate the NF-кB signaling pathway [17]. More and more studies regarding the effects of single herb in ZJP on gastric diseases is available.…”

Section: Discussionmentioning

confidence: 99%

“…Evodiamine, a botanical alkaloid extracted from the dried unripe fruit of Evodia rutaecarpa Bentham, exhibits extensive pharmacological effects including anti-obesity, anti-tumor, vasodilatory, antiin ammatory effects and gastric protection [20]. From a clinical application, ZJP is widely used in gastrointestinal diseases due to strong anti-in ammation, antimicrobial and protection of gastric mucosa [17]. In addition, ZJP and its active ingredients have obvious therapeutic effects against both in ammation and gastric mucosal damage in the stomach [21][22].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Zuojin Pill on chronic atrophic gastritis induced by Helicobacter pylori through JMJD2B/COX-2/VEGF

Wu¹,

Bao²,

Zhang³

et al. 2020

Preprint

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Background: Zuojin Pill (ZJP), a famous Chinese medicinal formula, is widely accepted for treatment of chronic atrophic gastritis (CAG) in China. This study aimed to explore the therapeutic effects and mechanisms of ZJP in Helicobacter pylori (H. pylori) - induced chronic atrophic gastritis (CAG) in vivo and in vitro. Methods: CAG rat model was induced by H. pylori. ZJP (0.63, 1.26, and 2.52 g/kg, respectively) was administered orally for four weeks. Therapeutic effects of ZJP were identified by H&E staining and serum indices. In addition, cell viability, morphology and proliferation were detected by cell counting kit-8 (CCK8) and high-content screening assay (HCS), respectively. Moreover, relative mRNA expression and protein expression related to JMJD2B/COX-2/VEGF axis was detected to investigate the potential mechanisms of ZJP in CAG.Results: Results showed the symptoms (weight loss and gastric mucosa damage) of CAG were alleviated, and the contents of TNF-α in serum was markedly decreased after treating with ZJP. Moreover, cell viability, proliferation and morphology changes of GES-1 cells were ameliorated by ZJP intervention. In addition, proinflammatory genes and JMJD2B/COX-2/VEGF axis related genes were suppressed by ZJP administration in vitro and in vivo. Meanwhile, immunohistochemistry (IHC) and western blot confirmed down-regulation of these genes by ZJP intervention. Conclusion: ZJP treatment can alleviate gastric mucosal damage induced by H. pylori via JMJD2B/COX-2/VEGF axis.

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“…The relation between the mitogen active protein kinase (MAPK)/NF-κB signal pathway and the cytokine regulation and oxidative stress was investigated [34]. It has also been shown that they have active roles in the pathogenesis of the gastric lesions stemming from ethanol [35]. NF-κB, which is expressed almost in all cells, acts as a mediator for various genes that form the immune response and for some inflammatory reactions [36].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Tanyeli

Eraslan

Polat

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol. Methods: Thirty-two sprague Dawley male rats were randomly divided into four groups, including eight rats in each group as follows: Group 1: control; Group 2: ethanol 5 mL/kg; Group 3: ethanol 5 mL/kg + 5 nmol/kg salusin-α; Group 4: ethanol 5 mL/kg + 5 nmol/kg salusin-β. Results: The salusin-α level increased at a significant level in the ulcer group formed with ethanol (p < 0.001); the change in the salusin-β level is not significant. As for malondialdehyde (p < 0.05) and myeloperoxidase (p < 0.001), when compared with the control group, tumor necrosis factor-α (p < 0.05) levels increased in the group to which ethanol was applied and decreased significantly with the application of salusins. Levels of GSH and IL-1β did not change at a significant level. In addition, histopathologic analysis demonstrated that, in salusin-administered groups, mucosal injury and caspase-3 expressions were reduced. Conclusions: The suppression of salusin-α and salusin-β on caspase-3 expression by means of their effects on

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Anti-ulcerogenic effect of Zuojin Pill against ethanol-induced acute gastric lesion in animal models

Cited by 43 publications

References 20 publications

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Therapeutic effect of Zuojin Pill on chronic atrophic gastritis induced by Helicobacter pylori through JMJD2B/COX-2/VEGF

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

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