Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao, Zhihui; Gong, Shilin; Wang, Shumin; Ma, Chi

doi:10.1016/j.intimp.2015.07.030

Cited by 81 publications

(42 citation statements)

References 32 publications

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“…Interestingly, ROCK2 was identified as a downstream effector of androgen/androgen receptor pathway, affecting migration and invasion of pancreatic cancer cells through the transcription of miR‐135a, and inducing endothelial cell migration . In addition, ROCK2 expression was significantly elevated in ethanol‐induced gastric ulcer in mice . Even though the association between those predictors and ROCK2 expression is not widely addressed in the current literature, our results with OSCC clinical samples corroborate with those previous findings.…”

Section: Discussionsupporting

confidence: 90%

Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas

Dourado

Oliveira

Sawazaki‐Calone

et al. 2017

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 90%

Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas

Dourado

Oliveira

Sawazaki‐Calone

et al. 2017

J Oral Pathology Medicine

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“…Evidence has indicated that alcohol ingestion activates the innate immune system by changing the levels of inflammatory cytokines [48]. As a representative inflammatory cytokine with pleiotropic functions, TNF- α is closely associated with the progression of many inflammatory disorders [49].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol‐Induced Acute Liver Injury

Liu

Wang

et al. 2017

Oxidative Medicine and Cellular Longevity

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In the present study, the components of A. cinnamomea (AC) mycelia were systematically analyzed. Subsequently, its hepatoprotective effects and the underlying mechanisms were explored using a mouse model of acute alcohol-induced liver injury. AC contained 25 types of fatty acid, 16 types of amino acid, 3 types of nucleotide, and 8 types of mineral. The hepatoprotective effects were observed after 2 weeks of AC treatment at doses of 75 mg/kg, 225 mg/kg, and 675 mg/kg in the mouse model. These effects were indicated by the changes in the levels of aspartate aminotransferase, alanine aminotransferase, several oxidation-related factors, and inflammatory cytokines in serum and/or liver samples. AC reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis in liver detecting via histological and TUNEL assay. In addition, AC reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-κB (NF-κB) in the liver samples. Collectively, AC-mediated hepatoprotective effects in a mouse model of acute alcohol-induced liver injury are the result of reduction in oxidative stress. This may be associated with Akt/NF-κB signaling. These results provide valuable evidence to support the use of A. cinnamomea as a functional food and/or medicine.

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“…c o m / l o c a t e / i n t i m p extensively reported to participate in ischemia and reperfusion [12,13]. Rho protein is also implicated in the regulation of NF-κB signal transduction cascades related to inflammation [14]. The relationship between Rho/ROCK and NF-κB signaling in myocardial ischemia has not been elucidated.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Crocetin ester improves myocardial ischemia via Rho/ROCK/NF-κB pathway

Huang

Chen

Wang

et al. 2016

International Immunopharmacology

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Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Cited by 81 publications

References 32 publications

Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas

Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas

Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol‐Induced Acute Liver Injury

Crocetin ester improves myocardial ischemia via Rho/ROCK/NF-κB pathway

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