The attitude regulation of spacecraft using continuous time execution of the control law is not always affordable for the low-cost satellites with limited wireless resources. Of late, within the ambit of control of systems over networks, event-triggered control has proved to be instrumental in ensuring acceptable closed-loop performance while respecting bandwidth constraints of the underlying network. Aligned with these design objectives, a robust event-triggered attitude control algorithm is proposed to regulate the orientation of a flexible spacecraft subjected to parametric uncertainties, external disturbances, and vibrations due to flexible appendages. The control law is developed using a state-dependent single feedback vector, which further assists in obeying the constrained network. The current information of this vector is updated to the onboard controller only when the predefined triggering condition is satisfied. Thus, the control input is updated through communication channel only when there is a need, which ultimately helps in saving the communication resources. The system trajectories, under the proposed approach, are guaranteed to be uniformly ultimately bounded (UUB) in a small neighborhood of origin by using a high gain. Moreover, the practical applicability of the proposed scheme is also proved by showing the Zeno free behavior in the proposed control, i.e., it avoids the accumulation of the triggering sequence. The numerical simulations results are indeed encouraging and illustrate the effectiveness of the designed controller. Moreover, the numerical comparative analysis shows that the proposed approach performs better than periodically sampled data technique and sliding mode-based event-triggered technique.INDEX TERMS Flexible spacecraft, attitude regulation control, limited data transmission, communication constraints, event-trigger, robust control, Zeno behavior, modified Rodrigues parameters (MRP).