Anti-Viral Effects of Medicinal Plants in the Management of Dengue: A Systematic Review

Frederico, Éric Heleno Freira Ferreira; Cardoso, André Luiz Bandeira Dionísio; Moreira-Marconi, Eloá; Sá-Caputo, Danúbia da Cunha de; Guimarães, Carlos Alberto Sampaio; Dionello, Carla da Fontoura; Morel, Danielle Soares; Paineiras-Domingos, Laisa Liane; Souza, Patricia Lopes de; Brandão-Sobrinho-Neto, Samuel; Carvalho-Lima, Rafaelle Pacheco; Guedes-Aguiar, Eliane de Oliveira; Costa-Cavalcanti, Rebeca Graça; Kutter, Cristiane; Bernardo-Filho, Mário

doi:10.21010/ajtcam.v14i4s.5

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…However, further studies are needed to confirm these observations. Several studies showed that polyphenols, triterpenes, anthraquinones, saponins, and polysaccharides that were isolated from natural plants can inhibit the replication of herpes viruses [27]. A large number of plant-derived and synthetic anti-HSV agents have also been described [4,28].…”

Section: Resultsmentioning

confidence: 99%

Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2

et al. 2020

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Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) belong to the herpesviridae family and cause neurological disorders by infecting the nervous system. The present study aimed to investigate the effects of Rosmarinus officinalis L. (rosemary) extract against HSV-1 and HSV-2 in vitro. The antioxidant activity of this extract was investigated by superoxide anion and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical assays. Rosemary extract was evaluated by an HSV-1 antiviral assay, in which viral replication in Vero cells was determined and quantified using a cytopathic effect assay. The present study showed that rosemary extract at 30 µg/ml caused 55% inhibition of HSV-1 plaques, whereas 40 µg/ml rosemary extract caused 65% inhibition of HSV-2 plaques. The extracts completely inhibited HSV-1 and HSV-2 plaque formation at 50 µg/ml. Scavenging activity of the superoxide anion radical was observed at 65.74 mg/ml, whereas 50% scavenging activity of the DPPH radical was observed at 67.34 mg/ml. These data suggest that rosemary extract may be suitable as a topical prophylactic or therapeutic agent for herpes viral infections. However, further research is required to elucidate the plant’s active constituents, which may be useful in drug development.

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Section: Resultsmentioning

confidence: 99%

Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2

et al. 2020

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“…A systematic review of scientific studies, following guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA statement), was carried out [34] , [35] on the selected medicinal plants. Furthermore, the PubMed-NCBI database (http://www.ncbi.nlm.nih.gov/pubmed) was systematically searched for experimental trials and related bioassays.…”

Section: Methodsmentioning

confidence: 99%

Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies

Verma

Kumar

Singh³

et al. 2021

Biomedicine & Pharmacotherapy

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All the plants and their secondary metabolites used in the present study were obtained from Ayurveda, with historical roots in the Indian subcontinent. The selected secondary metabolites have been experimentally validated and reported as potent antiviral agents against genetically-close human viruses. The plants have also been used as a folk medicine to treat cold, cough, asthma, bronchitis, and severe acute respiratory syndrome in India and across the globe since time immemorial. The present study aimed to assess the repurposing possibility of potent antiviral compounds with SARS-CoV-2 target proteins and also with host-specific receptor and activator protease that facilitates the viral entry into the host body. Molecular docking (MDc) was performed to study molecular affinities of antiviral compounds with aforesaid target proteins. The top-scoring conformations identified through docking analysis were further validated by 100 ns molecular dynamic (MD) simulation run. The stability of the conformation was studied in detail by investigating the binding free energy using MM-PBSA method. Finally, the binding affinities of all the compounds were also compared with a reference ligand, remdesivir, against the target protein RdRp. Additionally, pharmacophore features, 3D structure alignment of potent compounds and Bayesian machine learning model were also used to support the MDc and MD simulation. Overall, the study emphasized that curcumin possesses a strong binding ability with host-specific receptors, furin and ACE2. In contrast, gingerol has shown strong interactions with spike protein, and RdRp and quercetin with main protease (M pro ) of SARS-CoV-2. In fact, all these target proteins play an essential role in mediating viral replication, and therefore, compounds targeting aforesaid target proteins are expected to block the viral replication and transcription. Overall, gingerol, curcumin and quercetin own multitarget binding ability that can be used alone or in combination to enhance therapeutic efficacy against COVID-19. The obtained results encourage further in vitro and in vivo investigations and also support the traditional use of antiviral plants preventively.

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“…Cleome spp., Lantana spp., and Lippia spp.) possess antiviral activity against yellow fever, and Dengue [76,81,[88][89]. These essential oils include spathulenol, bicyclogermacrene, β-caryophyllene, α-humulene, humulene epoxide II and phytol, germecrene-D, spathulenol, geranial, and limonene.…”

Section: Terpenoidsmentioning

confidence: 99%

Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs

Hosseini

Muñoz-Soto

Oliva-Ramírez

et al. 2020

CMC

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In this paper, we review the history of Dengue, the mechanism of infection, the molecular characteristics and components of Dengue, the mechanism of entry to the target cells, cyclization of the genome and replication process, as well as translation of the proteins for virus assembly. The major emphasis of this work is on natural products and plant extracts, which were used for as palliative or adjuvant treatment of Dengue. This review article also summarizes latest findings in regards to the marine products as effective drugs to target different symptoms of Dengue. Furthermore, an update on synthetic drugs for treating Dengue is provided in this review. As a novel alternative, we describe monoclonal antibody therapy for Dengue management and treatment.

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Anti-Viral Effects of Medicinal Plants in the Management of Dengue: A Systematic Review

Cited by 18 publications

References 24 publications

Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2

Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2

Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies

Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs

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