Anti‐Wr<sup>a</sup> in newborn twins

Arriaga, F; Palau, Javier; López, Francisca; Pérez, Tania; Guinot, María; Arilla, M.J.; Marty, M

doi:10.1046/j.1537-2995.1991.31491213311.x

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…Therefore, this antibody can be detected by agglutination in saline at room temperature and/or at 37°C by indirect antiglobulin test (IAT). Anti‐Wr a has occasionally caused hemolytic disease of the newborn (HDN) 5,6 and hemolytic transfusion reaction 7 …”

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confidence: 99%

“…Routine pretransfusional compatibility testing in our institution relies on AST 7 . We and others have previously reported the association of different degrees of hemolysis due to anti‐Wr a 5–7 . Thus, we were interested in knowing the incidence of Wr a antigen in the population from Valencia, Spain, and evaluated the incidence of anti‐Wr a and its different immunoglobulin classes and subclasses in this population.…”

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confidence: 99%

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Incidence of Wr^a antigen and anti‐Wr^a in a Spanish population

et al. 2005

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Incidence of Wr^a antigen and anti‐Wr^a in a Spanish population

et al. 2005

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“…Although there are reports of HDN due to LIA, it has been caused by anti‐Wr a only occasionally (Jorgensen & Jacobsen, 1974; Arriaga et al , 1991). However, HDN caused by anti‐Wr a may be underreported because most screening panels do not contain Wr(a)‐positive cells.…”

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confidence: 99%

Should pre-transfusion screening RBC panels contain Wr(a+) cells?

Coluzzi

Nicolò

Quattrocchi

et al. 2010

Transfusion Medicine

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Sometimes commercial RBC sets for the screening of irregular antibodies contain Wr(a+) cells. The aim of this study was to define the usefulness of employing RBC sets for the screening of irregular antibodies containing Wr(a+) cells in pre-transfusion tests. Anti-Wr(a) is a relatively common naturally occurring antibody in candidates to blood transfusion, although the risk of receiving a non-compatible unit is low. We have studied both the incidence of Wr(a) antibodies and the effects of having a Wr(a+) cell in the screening test on routine work in an unselected population of 787 patients requiring RBC transfusion and in 151 new blood donors. Irregular antibodies were found in 64 sera, 58 of which were specific for Wr(a) , 46 (5·8%) and 12 (7·9%) in patients and donors, respectively. The positive tested sera contained specific IgM in 16 cases, IgM + IgG in 13 cases and IgG in 27 cases. Anti-Wr(a) can usually be detected during cross-match procedures; therefore, the presence of Wr(a+) cells in pre-transfusion screening of blood recipients is not justified and it causes an undue increase in cost and time to unit release. Moreover, because of the rare association between anti-Wr(a) and haemolytic transfusion reaction, the use of Wr(a+) RBC-containing sets is also questionable in the countries that do not perform pre-transfusion cross-match tests.

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“…Indentification studies performed by a refer ence laboratory (Gamma Biologicals) re vealed an anti-Wright a (Wra) as the sole antibody responsible of the transfusion reac tion. Alloimune anti-Wra is a verv rare anti body directed against a low-frequency anti gen ( 1/1,000 patients) [2] and has been report ed as causing severe hemolytic disease of the newborn and transfusion reactions, usually associated to other red cell antibodies [3][4][5]. However, in this case anti-Wra was the only antibody detected, and the hemolytic trans fusion reaction observed was mild.…”

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confidence: 96%