Anti-yeast potential of lichen-extracted substances – An analytical review

Furmanek, Łukasz; Seaward, Mark R.D.

doi:10.1016/j.sajb.2023.08.018

Cited by 3 publications

(3 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recommendation of water as a solvent for lichen substances from an ecological viewpoint is emphasized in review papers on the genera Aspergillus (Furmanek et al 2022b ) and Fusarium (Furmanek et al 2022c ), yeasts (Furmanek and Seaward 2023 ) and macromycetes (Furmanek et al 2022a ). The results of the present study strongly support these recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…Lichen extracts, especially those obtained by ‘hot’ extraction methods due to the relatively higher concentrations of phenolic compounds determined can be considered in the future as natural agents used in various industrial branches, including forestry, fungal cultivation (anti- and pro-microbial agents), food preservatives, cosmetics (such as preservatives and sunscreens), phytopharmacology (dietary supplements) and medicine (drugs and antibiotics). Numerous of these suggestions have been considered in respect of Aspergillus , Fusarium , dermatophytes (Furmanek et al 2019 ; 2022b , c ) and yeasts (Furmanek and Seaward 2023 ) and for their phytopharmaceutical value based on substances which could be obtained from Cetraria islandica (Antropova et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the mycotoxins present in the lichens (Burkin and Kononenko 2014 , 2015 ) are mostly sparingly soluble in water (Santos et al 2022 ), thus reinforcing the health safety of potential water-based applications (cf. non-toxic water extracts: Kumar et al 2014 ).Many attempts in the laboratory to obtain lichen water extracts against fungi or bacteria have proved unsuccessful (e.g., Sargsyan et al 2021 ); although some of these provide a rationale for further research (macromycetes, genus Aspergillus and Fusarium : Furmanek et al 2022a , b , c and literature cited therein; yeast-like fungi: Furmanek and Seaward 2023 ), this requires qualification. From this perspective, the results of the present study show a promising direction for further laboratory research using extracted water-soluble phenolic metabolites.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens

Furmanek,

Czarnota,

Tekiela

et al. 2024

Planta

View full text Add to dashboard Cite

Main conclusion Rainwater most probably constitutes a relatively effective solvent for lichen substances in nature which have the potential to provide for human and environmental needs in the future. Abstract The aims were (i) to test the hypothesis on the potential solubility of lichen phenolic compounds using rainwater under conditions that partly reflect the natural environment and (ii) to propose new and effective methods for the water extraction of lichen substances. The results of spectrophotometric analyses of total phenolic metabolites in rainwater-based extracts from epigeic and epiphytic lichens, employing the Folin–Ciocalteu (F.–C.) method, are presented. The water solvent was tested at three pH levels: natural, 3, and 9. Extraction methods were undertaken from two perspectives: the partial imitation of natural environmental conditions and the potential use of extraction for economic purposes. From an ecological perspective, room-temperature water extraction (‘cold’ method) was used for 10-, 60-, and 120-min extraction periods. A variant of water extraction at analogous time intervals was an ‘insolation’ with a 100W light bulb to simulate the heat energy of the sun. For economic purposes, the water extraction method used the Soxhlet apparatus and its modified version, the ‘tea-extraction’ method (‘hot’ ones). The results showed that those extractions without an external heat source were almost ineffective, but insolation over 60- and 120-min periods proved to be more effective. Both tested ‘hot’ methods also proved to be effective, especially the ‘tea-extraction’ one. Generally, an increase in the concentration of phenolic compounds in water extracts resulted from an increasing solvent pH. The results show the probable involvement of lichen substances in biogeochemical processes in nature and their promising use for a variety of human necessities.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens

Furmanek,

Czarnota,

Tekiela

et al. 2024

Planta

View full text Add to dashboard Cite

show abstract

The cytotoxic potential of polyphenols extracted from eight lichen species and their antioxidant activity against the cancer cell lines

Furmanek,

Żurek,

Kapusta

et al. 2024

Biocatalysis and Agricultural Biotechnology

View full text Add to dashboard Cite

Gyrophoric Acid, a Secondary Metabolite of Lichens, Exhibits Antidepressant and Anxiolytic Activity In Vivo in Wistar Rats

Urbanska,

Karasova,

Jendzelovska

et al. 2024

IJMS

View full text Add to dashboard Cite

Gyrophoric acid (GA) is a secondary metabolite of various lichens. It exhibits various biological activities in vitro, but only one study has been carried out in vivo. Because our previous study showed that GA stimulates neurogenesis in healthy rats, the current study aimed to explore the potential of GA during stress-induced depressive-like states in male Wistar rats. In the experiment, pregnant females were used. In the last week of pregnancy, females were subjected to restraint stress. After birth, progeny aged 60 days were stressed repeatedly. The males were divided into three groups: control animals (CTR; n = 10), males with a depression-like state (DEP; n = 10), and GA-treated animals (GA; n = 10). GA males were treated with GA (per os 10 mg/kg) daily for one month, starting from the 60th postnatal day. Our results indicate that GA acts as an antioxidant, as shown by a lowered ROS level in leukocytes (p < 0.01). Moreover, it prolonged the time spent in open arms in the elevated plus maze (p < 0.001). Concomitantly, the stimulation of proliferative activity in hippocampal regions was seen (hilus p < 0.01; subgranular zone p < 0.001) when compared with DEP males. Additionally, the number of mature neurons in the CA1 region of the hippocampus increased markedly (p < 0.01), indicating the role of GA in the maturation process of neurons. Thus, our study points to the potential anxiolytic/antidepressant activity of GA. However, future studies are needed in this complex area.

show abstract

Anti-yeast potential of lichen-extracted substances – An analytical review

Cited by 3 publications

References 172 publications

A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens

A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens

The cytotoxic potential of polyphenols extracted from eight lichen species and their antioxidant activity against the cancer cell lines

Gyrophoric Acid, a Secondary Metabolite of Lichens, Exhibits Antidepressant and Anxiolytic Activity In Vivo in Wistar Rats

Contact Info

Product

Resources

About