Antiadhesive activity of ulvan polysaccharides covalently immobilized onto titanium surface

Gadenne, Virginie; Lebrun, Laurent; Jouenne, Thierry; Thébault, Pascal

doi:10.1016/j.colsurfb.2013.07.061

Cited by 66 publications

(65 citation statements)

References 39 publications

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“…These results confirm the success of chitosan deposit and suggest the peptide bond formation. Gadenne et al used also this type of covalent binding in order to graft polysaccharide via a silane onto titanium surface [54]. In the literature, chitosan grafting on Ti can be performed via imide bond formation using TESBA [22] or APTES associated with glutaraldehyde [25].…”

Section: Xps Analysismentioning

confidence: 98%

Relevant insight of surface characterization techniques to study covalent grafting of a biopolymer to titanium implant and its acidic resistance

D’Almeida

Amalric²,

Brunon³

et al. 2015

Applied Surface Science

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Section: Xps Analysismentioning

confidence: 98%

Relevant insight of surface characterization techniques to study covalent grafting of a biopolymer to titanium implant and its acidic resistance

D’Almeida

Amalric²,

Brunon³

et al. 2015

Applied Surface Science

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“…Furthermore, surfaces of contact lenses are designed to provide limited adhesion of corneal endothelial cells to intraocular lenses and thus avoid cytotoxicity. For longterm totally internal implant devices (e.g., heart valves or joint replacements), stable coatings such as immobilized polymers with antimicrobial or antiadhesive properties (e.g., polysaccharides, [50] AMPs [51] ), or crosslinked polymer hydrogels [52] protect against DAI by not dissipating over time. Ideal surfaces of percutaneous and permucosal devices have to support osseointegration and perimucosal sealing, because it is important to resist periimplant infections, for example, periimplantitis.…”

Section: Location-dependent Design Considerationsmentioning

confidence: 99%

“…[69] In addition, it was also demonstrated that thermoresponsive, nanopatterned polymer brushes allow triggered removal of debris after effective killing of bacteria. [70,79] Besides synthetic polymers, antifouling properties have also been obtained with polysaccharide coatings that decreased bacteria adhesion to a titanium surface up to 96% after 90 min of contact, [50] and agarose crosslinked on a solid support reduced the adhesion of proteins to device surfaces by >90%. [70,79] Besides synthetic polymers, antifouling properties have also been obtained with polysaccharide coatings that decreased bacteria adhesion to a titanium surface up to 96% after 90 min of contact, [50] and agarose crosslinked on a solid support reduced the adhesion of proteins to device surfaces by >90%.…”

Section: Polymer-coated Surfacesmentioning

confidence: 99%

Nanoscience‐Based Strategies to Engineer Antimicrobial Surfaces

et al. 2018

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Microbial contamination and biofilm formation of medical devices is a major issue associated with medical complications and increased costs. Consequently, there is a growing need for novel strategies and exploitation of nanoscience‐based technologies to reduce the interaction of bacteria and microbes with synthetic surfaces. This article focuses on surfaces that are nanostructured, have functional coatings, and generate or release antimicrobial compounds, including “smart surfaces” producing antibiotics on demand. Key requirements for successful antimicrobial surfaces including biocompatibility, mechanical stability, durability, and efficiency are discussed and illustrated with examples of the recent literature. Various nanoscience‐based technologies are described along with new concepts, their advantages, and remaining open questions. Although at an early stage of research, nanoscience‐based strategies for creating antimicrobial surfaces have the advantage of acting at the molecular level, potentially making them more efficient under specific conditions. Moreover, the interface can be fine tuned and specific interactions that depend on the location of the device can be addressed. Finally, remaining important challenges are identified: improvement of the efficacy for long‐term use, extension of the application range to a large spectrum of bacteria, standardized evaluation assays, and combination of passive and active approaches in a single surface to produce multifunctional surfaces.

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“…After incubation, the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 9 colonies were counted. 33 The results were presented in terms of value of antimicrobial activity (R(log)) and % bacterial reduction (D%) in Eq (3) and (4): Acute skin irritation test Acute skin irritation of 0.00 mmol Cu/g gel, 0.82 mmol Cu/g gel and 1.27 mmol Cu/g gel starch hydrogels was evaluated on rabbits using the OECD/OCDE 404 test. 34 This test was performed in a laboratory accredited by OECD following a procedure in compliance with GLP N° 7.35 New Zealand albino rabbits weighting 2.1-3.5 kg were used.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Starch Hydrogel Incorporated with Copper Nanoparticles

Villanueva

Diez

González

et al. 2016

ACS Appl. Mater. Interfaces

150

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In order to obtain an antimicrobial gel, a starch-based hydrogel reinforced with silica-coated copper nanoparticles (Cu NPs) was developed. Cu NPs were synthesized by use of a copper salt and hydrazine as a reducing agent. In order to enhance Cu NP stability over time, they were synthesized in a starch medium followed by a silica coating. The starch hydrogel was prepared by use of urea and water as plasticizers and it was treated with different concentrations of silica-coated copper nanoparticles (Si-Cu NPs). The obtained materials were characterized by Fourier transform infrared (FT-IR) spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, scanning electron microscopy (SEM), and rheometry. FT-IR and EPR spectra were used for characterization of Cu NPs and Si-Cu NPs, confirming that a starch cap was formed around the Cu NP and demonstrating the stability of the copper nanoparticle after the silica coating step. SEM images showed Cu NP, Si-Cu NP, and hydrogel morphology. The particle size was polydisperse and the structure of the gels changed along with particle concentration. Increased NP content led to larger pores in starch structure. These results were in accordance with the rheological behavior, where reinforcement by the Si-Cu NP was seen. Antimicrobial activity was evaluated against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial species. The hydrogels were demonstrated to maintain antimicrobial activity for at least four cycles of use. A dermal acute toxicity test showed that the material could be scored as slightly irritant, proving its biocompatibility. With these advantages, it is believed that the designed Si-Cu NP loaded hydrogel may show high potential for applications in various clinical fields, such as wound dressings and fillers.

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Antiadhesive activity of ulvan polysaccharides covalently immobilized onto titanium surface

Cited by 66 publications

References 39 publications

Relevant insight of surface characterization techniques to study covalent grafting of a biopolymer to titanium implant and its acidic resistance

Relevant insight of surface characterization techniques to study covalent grafting of a biopolymer to titanium implant and its acidic resistance

Nanoscience‐Based Strategies to Engineer Antimicrobial Surfaces

Antimicrobial Activity of Starch Hydrogel Incorporated with Copper Nanoparticles

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