Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property

Abstract

Objectives : Malvidin, a dietary anthocyanin can be a potent drug for the treatment of neuronal toxicity. The investigation was aimed to study the antioxidant role of malvidin against aluminum chloride (AlCl 3 )-induced neurotoxicity in rats. Methods : To evaluate the neuroprotective role of malvidin, the rats were divided into four different groups: group I received saline, group II received AlCl 3 , and groups III and IV were administered with 100 and 200 mg/kg malvidin after AlCl 3 for 60 days. During the evaluation period, all the groups were subjected to a behavioral test. On the 61st day of the study, rat brains were removed and used for a neurochemical assay. Results : From the present study, malvidin ameliorated the effects of AlCl 3 on behavioral parameters. Biochemical investigation revealed that oral treatment of malvidin shows neuroprotective effects through regulation of antioxidant levels and neuroinflammation in the AlCl 3 -exposed rats. Conclusion : The results indicate that malvidin possesses antioxidant activity via acetylcholinesterase inhibition and regulation of oxidative stress in neuronal cells. Hence, malvidin could be a potential drug in correcting Alzheimer’s disease.

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

“…From this study, the effective dose of malvidin can be suggested to range from 100 to 200 mg/kg in oral treatment (Gilani et al, 2022).…”

“…However, the neuroprotective effects of cyanidin in animal models of AD and PD have not reported yet. Another anthocyanin malvidin isolated from mulberries and grapes is reported to ameliorate oxidative stress, neuroinflammation, decrease AChE activity and improve cognitive functions in AD rats (Gilani et al, 2022). From this study, the effective dose of malvidin can be suggested to range from 100 to 200 mg/kg in oral treatment (Gilani et al, 2022).…”

“…Another anthocyanin malvidin isolated from mulberries and grapes is reported to ameliorate oxidative stress, neuroinflammation, decrease AChE activity and improve cognitive functions in AD rats (Gilani et al, 2022). From this study, the effective dose of malvidin can be suggested to range from 100 to 200 mg/kg in oral treatment (Gilani et al, 2022). An ex vivo study also demonstrated that malvidin exerted protection against Aβ induced neurotoxicity in a neuronal cell model of AD through the amelioration of oxidative stress, downregulation of BACE1 activity and increase in the viability and survivability of the cells (Shih et al, 2011).…”

Europinidin Attenuates Scopolamine-Induced Deficit Memory in Rats by Improving Neurobehavioral Activity, Inhibiting AChE Levels and BDNF Expression

“…The test apparatus comprises of a black ring shaped pool alienated into four quadrants (diameter of 120 cm and a height of 50 cm), filled with 30 cm of water (25±1°C). 37 A 9-cm-diameter immobile black podium was situated 1 cm below the water's surface. Each animal was placed in the water at random, facing the pool's wall.…”

“…38,39 A mounted web camera was used during Morris water test training amid 11:00 AM and 2:00 PM to eliminate performance differences in the rats. 37…”