Antiandrogentherapie Des Hirsutismus

Göbel, P; Cyran, J.; Frick, V.; Schindler, A. E.; Schwarz, Marc

doi:10.1530/acta.0.069s100

Cited by 2 publications

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“…haben zu einer Besserung der Symptome bei den verschiedenen Krankheitsbildern gefiihrt, die die Ergebnisse anderer Behandhmgen weir iibertriff~ [1,4,5,7]. Alle bisher zur Anwendung gekommenen Zubereitungen (s.o.)…”

Section: Diskussionunclassified

“…Dutch die Synthese des Cyproteron und seines Acetats dureh Wiechert 1963 [11] und die Entdeckung der antiandrogenen Eigenschaften dieser Steroide [8] ergab sieh in den letzten Jahren die MSglichkeit, Virilisierungserscheinungen bei Frauen durch eine spezifische Therapie mi$ diesem Antiandrogen zu behandeln [1,2,4,5,7,13,15]. Naeh tierexperimentellen Studien yon Neumann u. Mitarb.…”

Section: Introductionunclassified

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Wirkung und Nebenwirkung der Cyproteronacetatbehandlung

et al. 1974

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Effect and Side-Effect of Cyproteron-Acetat-TreatmentSummary. The effect of Cyproteron-Acetate was followed in 329 patients with idiopathic hirsutism, acne, seborrhoea oleosa or androgenetic alopecia. Cyproteronacetate is known to act as an antiandrogen with a strong progestin effect. Treatment was done in form of a "reverse sequence-therapy": 100 mg cyproteron-acetate from day 5 to 14 and 50 #g ethinylestradiol from day 5 to 25 and in a combination of 2 mg cyproteron-acetato and 50 mg ethinyl estradiol from day 5 to 25 of the cycle. The medication was continued for at least three months up to three years. In patients with ache and seborrhoea oleosa in more than 90% an improvement or a complete disappearance of the symptoms was observed after three months treatment. The effect in hirsutism and androgenetic alopecia was retarded. After 6 to 9 month of medication in nearly all cases a significant improvement could be obtained. Side effects during administration of cyproteronacetat mainly were of subjective nature and mostly disappeared after three months. Only in 2,5 % therapy had to be interrupted because of the intensity of the side effects. In 2000 treatment cycles no pregnancy occured.

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Section: Diskussionunclassified

Section: Introductionunclassified

Wirkung und Nebenwirkung der Cyproteronacetatbehandlung

et al. 1974

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The Development and Evaluation of an Ovulation Inhibitor (Diane®) Containing an Antiandrogen

Lachnit-Fixson¹

1979

Acta Obstet Gynecol Scand

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The combination of 2 mg cyproterone acetate, a pronounced antiandrogenic substance, in combination with 0.05 mg ethinyl estradiol has undergone intensive multiphasic clinical evaluation. The preparation with the trade name Diane@ has proven to be not only a reliable contraceptive, but also a very potent drug for the treatment of both acne and seborrhea, and of milder cases of hirsutism. The effect of Diane@ on markedly increased hair growth was not so pronounced. In addition to the presentation of the most pertinent steps of the clinical investigation of Diane@, the possible mode of actions of antiandrogens alone and in combination with an estrogen is discussed.

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Antiandrogentherapie Des Hirsutismus

Cited by 2 publications

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Wirkung und Nebenwirkung der Cyproteronacetatbehandlung

Wirkung und Nebenwirkung der Cyproteronacetatbehandlung

The Development and Evaluation of an Ovulation Inhibitor (Diane®) Containing an Antiandrogen

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