Antiangiogenic activity of neutral lipids, glycolipids, and phospholipids fractions of Pinus halepensis Mill. seeds

Kadri, Nabil; Khettal, Bachra; Adjebli, Ahmed; Cresteil, Thierry; Yahiaoui-Zaidi, R.; Barragan‐Montero, Véronique; Montéro, Jean-Louis

doi:10.1016/j.indcrop.2013.12.051

Cited by 24 publications

(18 citation statements)

References 39 publications

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“…Compounds that are anti-angiogenic but not toxic are beneficial in combating cancer by preventing the formation of new blood vessels that support tumor growth [26]. Endothelial cells form blood vessels, and many anti-angiogenic substances are directed against their function [27].…”

Section: Discussionmentioning

confidence: 99%

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

Koparal

2015

Zeitschrift Für Naturforschung C

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The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line.

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Section: Discussionmentioning

confidence: 99%

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

Koparal

2015

Zeitschrift Für Naturforschung C

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“…The neutral lipids, glycolipids and phospholipids of seeds of P. halepensis have inhibitory effects on antiangiogenic diseases and are able to fight cancer 19 . The seeds are also widely used, at least in Tunisia and similar cultural contexts, in the preparation of some antique dishes 20 . Furthermore, they have beneficial properties such as their anti-inflammatory 21 , antioxidant 22,23 and antineoplastic 24 activities.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

et al. 2016

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“…Additionally, the oil demonstrated a higher toxicity against cancer cell (5RP7), comparatively with healthy cells. In the work developed by Kadria et al [127], the antiangiogenic activity of neutral lipids, glycolipids and phospholipids, obtained from Pinus halepensis Mill. seeds, was evaluated in vitro using endothelial cells and in vivo using the CAM assay.…”

Section: Antiangiogenic Potential Of Extracts From Plant and Macrofunmentioning

confidence: 99%

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

et al. 2018

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a b s t r a c tAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesisrelated pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.

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Antiangiogenic activity of neutral lipids, glycolipids, and phospholipids fractions of Pinus halepensis Mill. seeds

Cited by 24 publications

References 39 publications

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

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