Protective Effects of &lt;i&gt;Pinus halepensis&lt;/i&gt; L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

Bouzenna, Hafsia; Samout, Noura; Amani, E.; Mbarki, Sakhria; Tlili, Zied; Rjeibi, Ilhem; Elfeki, Abdelfattah; Talarmin, Hélène; Hfaïedh, Najla

doi:10.5650/jos.ess15287

Cited by 15 publications

(8 citation statements)

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“…Consequently, Aspirin hepatotoxicity is demonstrated in light microscopic findings showing degenerative changes of patchy necrosis with substantial periportal infiltration of inflammatory cells including eosinophil, mast cells and lymphocytes typically as described by Prescott [35] . Additionally, the investigation of hepatic tissue homogenate showed increased lipid peroxidation marker (MDA) but decreased antioxidant enzymes (SOD and CAT) in agreement with previous records [36] indicating severe oxidative stress as a result of the acute hepatitis. On the other hand, serum samples from ginger and aspirin co-treated animals revealed close to normal values of transaminases (ALT and AST) confirmed by corrective changes on hepatic tissue sections of the same animals when examined by light microscope.…”

Section: Discussionsupporting

confidence: 91%

Protective Effect of Ginger Extract against Aspirin Induced Acute Gastric, Renal and Hepatic Damage in Rats

2017

Egyptian Journal of Pure and Applied Science

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The present study aimed to investigate the role of ginger in the prevention of aspirin-induced gastric and hepato-renal injury. Forty rats were distributed into 4 groups: normal control, aspirin, ginger control, and ginger plus aspirin. The normal control group was gavaged with saline for 7 days. The second group similarly treated with control except it was administered about 150 mg/kg aspirin on the 7 th day. The animal of third group was treated with ginger orally for 7 days. The forth group was similarly treated as the previous group except it was administrated aspirin on the 7 th day. The results of the biochemical analysis reported that ginger supplement preserved liver and kidney function serum markers close to normal. Also, histopathological findings demonstrated that pretreatment with ginger reversed aspirin-induced gastric, renal and hepatic tissues damage. Additionally, assessment of oxidative stress in tissues homogenates revealed that pretreatment with ginger attenuates significantly (p<0.001) lipid peroxidation marker malondialdehyde (MDA) and preserved the anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the three investigated organs. It could be concluded that ginger pretreatment attenuates the aspirin-induced gastric and hepato-renal lesions via inhibiting the resultant oxidative stress.

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Section: Discussionsupporting

confidence: 91%

Protective Effect of Ginger Extract against Aspirin Induced Acute Gastric, Renal and Hepatic Damage in Rats

2017

Egyptian Journal of Pure and Applied Science

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“…The combination of ASA with BDF further aggravated the histopathological lesions of liver more than BDF alone. A number of peer-review articles demonstrated the adverse impacts of ASA on the hepatic histoarchitecture (Huang et al, 2016;Bouzenna et al, 2016a;Bouzenna et al, 2016b). Shifting oxidant/antioxidant balance towards the oxidant side as evident by our findings and previous ones may contribute to the outcome by overproduction of ROS which attack critical macromolecules in the cells (Bhattacharyya et al, 2014;Bouzenna et al, 2016a;Bouzenna et al, 2016b).…”

Section: Effects Of Brodifacoum Acetylsalicylic Acid and Its Combinat...supporting

confidence: 55%

“…A number of peer-review articles demonstrated the adverse impacts of ASA on the hepatic histoarchitecture (Huang et al, 2016;Bouzenna et al, 2016a;Bouzenna et al, 2016b). Shifting oxidant/antioxidant balance towards the oxidant side as evident by our findings and previous ones may contribute to the outcome by overproduction of ROS which attack critical macromolecules in the cells (Bhattacharyya et al, 2014;Bouzenna et al, 2016a;Bouzenna et al, 2016b). Salicylates have the ability to uncouple oxidative phosphorylation allowing increase in metabolic rate resulting in increasing oxygen consumption, glucose utilization, and heat production.…”

Section: Effects Of Brodifacoum Acetylsalicylic Acid and Its Combinat...mentioning

confidence: 52%

“…Bromobenzene moiety in BDF causes uncoupling of mitochondrial oxidative phosphorylation (Maellaro et al, 1990) which may be implicated in increased generation of reactive oxygen species leading to lipid peroxidation and alteration in oxidant/antioxidant homeostasis. Oxidative stress also can be evoked by the metabolites of bromine group, nitrous bromide or hypobromous, through their interactions with the mitochondria (Blondin & Green, 1970).The marked reduction in the hepatic NO level and CAT activity in the combination group is matched with a broad spectrum of data indicated interruption of redox homeostasis under ASA challenge (Inkielewicz & Czarnowski, 2008;Bhattacharyya et al, 2014;Zeren et al, 2016;Bouzenna et al, 2016a;Bouzenna et al, 2016b). Increased LPO negatively impacted the physicochemical characters, fluidity and integrity of the cell membrane resulting in hepato-cellular damage and necrosis (Dobrzynska et al, 2008) as confirmed by the histopathological finding of this study.…”

Section: Discussionmentioning

confidence: 97%

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Effects of Brodifacoum, Acetylsalicylic Acid and Its Combination on Haemostatic, Hematological and Hepatic Markers of Wild Rat Rattus Rattus

2019

Assiut University Journal of Multidisciplinary Scientific Resea

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Development of resistance in rodents against rodenticides represents a major challenge for rat management strategies in the light of heavy damage and infestation of crop fields. The aim of this study is to examine the effects of brodifacoum (BDF), acetylsalicylic acid (ASA), and a novel formulation of both anticoagulants on haemostatic and hematological parameters, hepatic redox status and histoarchitecture. Forty eight adult female wild rats (Rattus rattus) were randomly and equally divided into three groups, eight rats each. BDF induced a significant increase in bleeding and prothrombine time, lipid peroxidation (LPO) and decrease in factor VII and IX and hepatic nitric oxide (NO) levels and catalase (CAT) activity, and eosinophils, lymphocytes and monocytes count. Rats in the combination group were characterized by a significant increase in clotting and prothrombin time and ionized calcium (Ca +2 ) level together with a significant decrease in factors VII, IX and NO levels, platelet count, mean platelet volume, and hepatic CAT activity. ASA was responsible for a significant increase in bleeding time, factor IX level and hepatic CAT activity, and decrease in hepatic NO level. Adverse changes in hepatic histoarchitecture were observed following each of BDF and ASA exposure. The combination of ASA with BDF further aggravated the histopathological lesions of liver more than BDF alone. It was concluded that ASA induced a joint action with BDF especially regarding the haemostatic markers and hepatocellular features.

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“…Apart from APAP, other NSAIDs can also cause liver injuries. It was reported that the essential oil of Pinus halepensis L. could correct the parameters, including thiobarbituric acid‐reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), which were all altered due to aspirin‐induced liver injury in rats (Bouzenna et al., ). In addition, in mice with diclofenac‐induced liver injury, polysaccharides from Millettiapulchra kurz var‐laxior (Dunn) Z. Wei attenuated oxidative stress, reduced inflammation, and improved drug‐metabolizing enzyme activity (Huang et al., ).…”

Section: Protective Effects Of Natural Products On Drug‐induced Livermentioning

confidence: 99%

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even cancers. Liver injuries have been a serious public health problem worldwide. Numerous natural products and their bioactive components have shown protective action for liver injuries, such as blueberry, cactus fruits, Pueraria lobate, betaine, and silymarin. The underlying mechanisms mainly include antioxidation, anti-inflammation, anti-apoptosis, anti-necrosis, repairing damaged DNA, regulating the metabolism of lipids, and modulating primary bile acid biosynthesis. This review summarizes the natural products and bioactive compounds with protective effects on liver injuries caused by chemicals, and special attention is paid to the mechanisms of action. This updated information can be helpful to prevent and treat liver-related diseases, especially chemical-induced liver injuries.

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Protective Effects of <i>Pinus halepensis</i> L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats

Cited by 15 publications

References 50 publications

Protective Effect of Ginger Extract against Aspirin Induced Acute Gastric, Renal and Hepatic Damage in Rats

Protective Effect of Ginger Extract against Aspirin Induced Acute Gastric, Renal and Hepatic Damage in Rats

Effects of Brodifacoum, Acetylsalicylic Acid and Its Combination on Haemostatic, Hematological and Hepatic Markers of Wild Rat Rattus Rattus

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

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