2005
DOI: 10.1016/j.ejphar.2005.02.035
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Antiangiogenic activity of β-eudesmol in vitro and in vivo

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Cited by 126 publications
(92 citation statements)
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“…The intraperitoneal injection of b-eudesmol induced a marked reduction in angiogenesis than that of hydrocortisone ( Table 3). 21) b-Eudesmol inhibits tube formation (angiogenesis) of endothelial cells in the rat aorta (unpublished data). The antiangiogenic eŠect of b-eudesmol is greater than that of hydrocortisone ( Fig.…”
Section: Multidirectional Actions Of B-eudesmolmentioning
confidence: 87%
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“…The intraperitoneal injection of b-eudesmol induced a marked reduction in angiogenesis than that of hydrocortisone ( Table 3). 21) b-Eudesmol inhibits tube formation (angiogenesis) of endothelial cells in the rat aorta (unpublished data). The antiangiogenic eŠect of b-eudesmol is greater than that of hydrocortisone ( Fig.…”
Section: Multidirectional Actions Of B-eudesmolmentioning
confidence: 87%
“…2(B)). 21) The blockade of extracellular signal-related kinase 1/2 by b-eudesmol may be the common mechanism for its antiangiogenic action. Therefore, b-eudesmol exhibits the following multiple pharmacological actions: 1) desensitization (channel blocking action) of nAChR, 2) antiangiogenic actions in the vascular endothelium, and 3) neuronal diŠerentiation induction (Fig.…”
Section: Multidirectional Actions Of B-eudesmolmentioning
confidence: 99%
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“…The latency to escape also showed a trend to decrease in Yueju-treated mice [13]. Many active components in Yueju are essential oils that may be extracted with ethanol, such as α-cyperone and β-cyperone in Xiang Fu and atractylin and hinesol in Cang Zhu [15], [29]. The effective components of Yueju regulate glutamate in a way similar to ketamine, and require further investigation.…”
Section: The Yueju Pillmentioning
confidence: 99%
“…1 Phytochemical studies have shown that LAR is rich in sesquiterpene compounds. [2][3][4] Bioassays demonstrated that extracts/ sesquiterpene compounds from LAR have various pharmacological activities, such as anti-inflammatory, 3,5,6 antiulcer, [7][8][9] anti-lipid-peroxidation 10 and antitumor [11][12][13] activities. Apoptosis induction 14,15 and antiangiogenesis 16 have been implicated in the anticancer properties of one of the LAR sesquiterpenes-namely, atractylenolide І (AT-I).…”
Section: Introductionmentioning
confidence: 99%