Antiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats

Abstract

Background: Cadmium has negative effects on various tissues of the body while selenium has antioxidant activities. Moreover, the benefits of exercise training for apoptotic factors including caspase-3 and cytochrome c, as well as cyclin D, have been regarded. Objectives: Therefore, the present study aimed to evaluate the anti-apoptotic effects of continuous training and selenium consumption on the liver tissue of cadmium-exposed rats. Methods: In this study, 25 rats were selected and randomly divided into five groups of five rats including: (1) control, (2) selenium consumption, (3) continuous training, (4) continuous training with selenium consumption, and (5) sham. For eight weeks, groups 1 to 4 received peritoneal cadmium (2 mg/kg) daily; groups 2 and 4 received peritoneal selenium (0.23 mg/kg) daily; and groups 3 and 4 performed continuous training three sessions per week. Caspase-3, cytochrome c, and cyclin D were measured at the protein level. Results: Cadmium consumption significantly increased the protein levels of caspase-3 and cytochrome c and decreased cyclin D in rats (P = 0.001). Selenium consumption and continuous training significantly decreased the protein levels of caspase-3 and cytochrome c and increased cyclin D in rats exposed to cadmium (P = 0.001). Continuous training along with selenium consumption had interactive effects on increasing the protein levels of cyclin D in rats exposed to cadmium (P = 0.02). Conclusions: It appears that continuous training and selenium consumption have interactive anti-apoptotic effects in the liver tissue of cadmium-exposed rats.

Antioxidant Effect of High Intensity Interval Training on Cadmium-Induced Cardiotoxicity in Rats

“…In the human body, Cd is accumulated with a long biological half-life (3). It has been reported that Cd can contribute to stimulate the formation of reactive oxygen species (ROS) and consequently induce the damage to different cells (4,5). Cd causes abnormal expression of antioxidants in cells as well as increases deoxyribonucleic acid (DNA) damage and lipid peroxidation (6,7).…”