Antiasthmatic activity of 2-piperidone by selective animal models

Mamillapalli, Vani; Shaik, Abdul Rahaman; Avula, Prameela Rani

doi:10.35333/jrp.2020.155

Cited by 5 publications

(4 citation statements)

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“…However, the smallest peak area intensity of proanthocyanidin A2 indicates its limited production by B. haynesii R2MCFF61. 2-piperidone is a well-known bioactive compound with antioxidant, anti-inflammatory and anticancer properties [60]. Although this compound is mainly produced in the host fruit, it has also been reported from a different endophytic Bacillus sp.…”

Section: Resultsmentioning

confidence: 99%

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Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Sharma,

Agarwal,

Bhardwaj

et al. 2024

Preprint

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Endophytes share a complex intimate relationship due to which they are capable of synthesizing metabolites that are either similar or derivative of host bioactive compounds. Such endophytes especially from medicinal plants can be prospected for commercial-scale production of the therapeutic compound. Thus, the study evaluates the antioxidant and anti-inflammatory potential of Momordica charantia fruit endophyte Bacillus haynesii R2MCFF61, and determines its metabolite profile through LC-Q-TOF-MS for the bioactive compounds produced. B. haynesii R2MCFF61 showed significant antioxidant and anti-inflammatory potential with increased DPPH scavenging activity in the standard compound and inhibition of protein denaturation respectively. The metabolic profile of this endophyte showed 23 compounds, mostly consisting of metabolites from lipid, phenylpropanoid and triterpenoid pathways. B. haynesii R2MCFF61 showed production of cucurbitane-triterpenoids namely Momordicoside K, 19-dimethoxycucurbita-5(10),6,22(E),24-tetraen-3β-ol and 23(E)-7β-methoxycucurbita-5,23,25-trien-3β-ol. These compounds are mainly produced by M. charantia fruit and their production by its endophyte is reported for the first time. Thus, these results indicate the promising therapeutic potential of B. haynesii R2MCFF61 which can be utilized as a low-cost sustainable source of these bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Metabolite Profiling Using Liquid Chromatography Quadrupole ...mentioning

confidence: 99%

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Sharma,

Agarwal,

Bhardwaj

et al. 2024

Preprint

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“…Where T1 = PCT average before test drug administration and T2 = PCT average after test drug administration 25,1,32,33 .…”

Section: In-vivo Model / Animal Model: Histamine-inducedmentioning

confidence: 99%

Untitled

2022

IJPSR

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Antihistamines appear to be the mainstay in allergic reaction treatment. Allergy is rooted in the primary rejection reaction of parasites in which histamine derived from mast cells generates an immediate aggressive environment, and eosinophils are recruited for killing. Antihistamines are medicinal products used to treat allergic rhinitis, conjunctivitis, urticaria, cold and flu, tachyphylaxis, motion sickness, and acute allergic reactions. A vast number of animals can be used for this activity, with rodents (inbred mice and rats) and guinea-pigs being the most common models, which are easy to maintain and relatively economical compared to other available models. Therefore, animal models used in asthma are greatly useful in antihistaminic studies because they promise new insights into human allergic symptoms. The available in-vivo and in-vitro models are used to investigate the mechanism of action of drugs with antihistaminic activity. This work aims to bring all the different in-vivo animal models and in-vitro techniques together for conducting antihistaminic activity research. INTRODUCTION:Asthma is a widespread and persistent airway inflammatory disorder 1 . It is a disorder in which bronchial tubes lead to coughing, tightness of the chest, and difficulty breathing. Histamine is synthesized by the L-histidine decarboxylase enzyme from L-histidine and stored in granules of mast cells and basophils 1 . Histamine play an important role in autoimmune pathology and its mechanism, as well as in autoimmune allergic, malignant, and inflammatory disease pathogenesis, such as chronic urticarial, atopic dermatitis, auto-immune myocardium, multiple sclerosis, experi-mental autoimmune encephalomyelitis, allergic rhinitis, acute anaphylaxis, asthma, atherosclerosis, multiple sclerosis, and malignant melanoma respectively 2, 3 . Histamine has a significant role in allergic ailments QUICK RESPONSE CODE

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“…Cyclic amides (lactams) and their derivatives demonstrate elastase inhibition [ 1 ], profound antihistaminic activity [ 2 ], and a hepatoprotective effect [ 3 ]; they are researched as components of anticancer drugs [ 4 ], electrolytes for batteries [ 5 ], and as ligands for catalytic reactions [ 6 ]. The functional properties of cyclic amides are intrinsically linked with the intermolecular interactions that they realize.…”

Section: Introductionmentioning

confidence: 99%

Thermochemistry of Solution, Solvation, and Hydrogen Bonding of Cyclic Amides in Proton Acceptor and Donor Solvents. Amide Cycle Size Effect

et al. 2021

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In the present work, the thermochemistry of solution, solvation, and hydrogen bonding of cyclic amides in proton acceptor (B) and proton donor (RXH) solvents were studied. The infinite dilution solution enthalpies of δ-valerolactam, N-methylvalerolactam, ε-caprolactam, and N-methylcaprolactam were measured at 298.15 K. The solvation enthalpies of cyclic amides were calculated based on the measured solution enthalpies and sublimation/vaporization enthalpies from literature. The enthalpies of hydrogen bonding between cyclic amides and proton acceptor and donor solvents were then calculated as a difference between the total solvation enthalpy and the non-specific contribution. The latter was estimated via two different approaches in proton donor and proton accepting solvents. The effect of the cycle size on the strength of hydrogen bonding of the cyclic amides in solution is discussed.

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Antiasthmatic activity of 2-piperidone by selective animal models

Cited by 5 publications

References 0 publications

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Untitled

Thermochemistry of Solution, Solvation, and Hydrogen Bonding of Cyclic Amides in Proton Acceptor and Donor Solvents. Amide Cycle Size Effect

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