Antibacterial activities of mechanochemically synthesized perovskite strontium titanate ferrite metal oxide

Zhang, Li; Tan, Pei Yun; Chow, C. K.; Lim, Chee Kian; Tan, Ooi Kiang; Tse, Man Siu; Sze, Chun Chau

doi:10.1016/j.colsurfa.2014.05.032

Cited by 35 publications

(25 citation statements)

References 38 publications

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“…In fact, both the release of Sr 2+ from the BBG-Sr glass particles and its antibacterial activity toward P. aeruginosa are dose dependent (Figure 3c and 4c). This observation is consistent with the contribution of the released Sr 2+ to the antibacterial activity of BBG-Sr, 25,35 suggesting that the BBG-Sr's activity toward P. aeruginosa may result from a synergist effect of several independent factors (e.g., Sr 2+ release, pH increase, among others). It is remarkable that in the case of BBG -Sr there is a concentration dependence of the antibacterial activity.…”

Section: Acs Biomaterials Science and Engineeringsupporting

confidence: 85%

“…On the other hand, the burst release of cations after 1 day led to an increase of pH (≈1 unit of pH, Figure 3d), which might be related with the observed BBGs antibacterial properties. Indeed, Zhang et al, 25 while studying BGs, correlated mainly the pH increase in the solution with antibacterial activity. The lower release of Ca 2+ into the BBG-Ca solution observed in the present work ( Figure 3c) might explain the lower increase in the solution pH ( Figure 3d), when compared with the dissolution solutions of BBG-Mg and BBG-Sr (e.g., the average of all concentrations for BBG-Mg at day 1 is 8.76, for BBG-Ca is 8.35, and for BBG-Sr is 8.90).…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

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Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications

Fernandes

Martins

Neves

et al. 2016

ACS Biomater. Sci. Eng.

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Three novel borosilicate bioactive glasses (BBGs) were prepared and used to investigate their bioactive and antibacterial properties. The BBGs were prepared by melt-quenching using different glass modifiers, i.e. Mg 2+ , Ca 2+ , and Sr 2+ , and their amorphous nature was confirmed by X-ray diffraction. Scanning electron microscopy with energy dispersive X-ray spectroscopy allowed the visualization of apatite-like structures upon 7 days of immersion in simulated body fluid. BBG-Ca generated surface structures with a Ca/P ratio ≈1.67, while the surface of the BBG-Sr was populated with structures with a Sr/P ratio ≈1.7. Moreover, bacterial tests showed that the BBG-Mg and BBG-Sr glasses (at concentrations of 9, 18, 36, and 72 mg/ mL) present antibacterial characteristics. In particular, BBG-Sr, at concentrations of 9 mg/mL, exhibited bacteriostatic activity against Pseudomonas aeruginosa, and at concentrations ≥18 mg/mL it was able to eradicate this bacterium. These results evidence an antibacterial activity dependent on the BBGs composition, concentration, and bacterial species. Cellular studies showed that the developed BBGs do not present a statistically significant cytotoxic effect against Saos-2 cells after 3 days of culture, showing better performance (in the cases of BBG-Ca and BBG-Sr) than commercial 45S5 Bioglass up to 7 days of culture. Overall, this study demonstrates that BBGs can be effectively designed to combine bioactivity and intrinsic antibacterial activity targeting bone tissue engineering applications.

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Section: Acs Biomaterials Science and Engineeringsupporting

confidence: 85%

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications

Fernandes

Martins

Neves

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

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“…New visible light active materials including CuFeO 2 [ 116 ], CuY x Fe 2-x O 4 [ 117 ], LaFeO 3 [ 118 ] have been reported as photocatalysts. Strontium titanate ferrite has been reported to have antibacterial activity under visible light irradiation [ 119 ]. Other transition metal ion centered photocatalyst materials reported include: manganese centered CuMn 2 O 4 , and ZnMn 2 O 4 [ 120 ], Chromium centered BaCr 2 O 4 [ 121 ] and SrCrO 4 [ 122 ], Cobalt centered NiCo 2 O 4 [ 123 ], CuCo 2 O 4 [ 117 ], LaCoO 3 and La0.9Sr0.1CoO 3 the latter of which demonstrated photocatalytic disinfection against E. coli [ 124 ].…”

Section: Novel Photocatalytic Materialsmentioning

confidence: 99%

A Review of Heterogeneous Photocatalysis for Water and Surface Disinfection

et al. 2015

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Photo-excitation of certain semiconductors can lead to the production of reactive oxygen species that can inactivate microorganisms. The mechanisms involved are reviewed, along with two important applications. The first is the use of photocatalysis to enhance the solar disinfection of water. It is estimated that 750 million people do not have accessed to an improved source for drinking and many more rely on sources that are not safe. If one can utilize photocatalysis to enhance the solar disinfection of water and provide an inexpensive, simple method of water disinfection, then it could help reduce the risk of waterborne disease. The second application is the use of photocatalytic coatings to combat healthcare associated infections. Two challenges are considered, i.e., the use of photocatalytic coatings to give “self-disinfecting” surfaces to reduce the risk of transmission of infection via environmental surfaces, and the use of photocatalytic coatings for the decontamination and disinfection of medical devices. In the final section, the development of novel photocatalytic materials for use in disinfection applications is reviewed, taking account of materials, developed for other photocatalytic applications, but which may be transferable for disinfection purposes.

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“…During the synthesis process, atoms in the perovskite lattice can be substituted with silver atoms and released in the form of ions into the wound to ensure anti-microbial activity. It is already known that perovskites are efficient against Gram-negative and Gram-positive bacteria with minimal cytotoxicity [ 25 , 26 , 27 , 28 , 29 ]. However, their efficacy in the form of tissue engineering scaffolds remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Design of Novel Perovskite-Based Polymeric Poly(l-Lactide-Co-Glycolide) Nanofibers with Anti-Microbial Properties for Tissue Engineering

et al. 2020

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There is a growing need for anti-microbial materials in several biomedical application areas, such are hernia, skin grafts as well as gynecological products, owing to the complications caused by infection due to surgical biomaterials. The anti-microbial effects of silver in the form of nanoparticles, although effective, can be toxic to surrounding cells. In this study, we report, for the first time, a novel biomedical application of Ag0.3Na1.7La2Ti3O10-layered perovskite particles, blended with poly(L-lactide-co-glycolide) (PLGA), aimed at designing anti-microbial and tissue engineering scaffolds. The perovskite was incorporated in three concentrations of 1, 5, 10 and 15 w/w% and electrospun using dimethylformamide (DMF) and chloroform. The morphology of the resultant nanofibers revealed fiber diameters in the range of 408 to 610 nm by scanning electron microscopy. Mechanical properties of perovskite-based nanofibers also matched similar mechanical properties to human skin. We observed impressive anti-microbial activity, against Gram-negative, Gram-positive bacteria and even fungi, to Ag0.3Na1.7La2Ti3O10 in powder as well as nanofiber-incorporated forms. Furthermore, cytotoxicity assay and immunocytochemistry revealed that perovskite-based nanofibers promoted the proliferation of human dermal fibroblasts whist maintaining normal cellular protein expression. Our study shows that perovskite-nanofibers have potential as scaffolds for biomedical applications with anti-microbial needs.

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Antibacterial activities of mechanochemically synthesized perovskite strontium titanate ferrite metal oxide

Cited by 35 publications

References 38 publications

Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications

Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications

A Review of Heterogeneous Photocatalysis for Water and Surface Disinfection

Design of Novel Perovskite-Based Polymeric Poly(l-Lactide-Co-Glycolide) Nanofibers with Anti-Microbial Properties for Tissue Engineering

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