Antibacterial activities of the methanol extracts of Canarium schweinfurthii and four other Cameroonian dietary plants against multi-drug resistant Gram-negative bacteria

Abstract

Bacterial infections are among the major cause of morbidity and mortality worldwide. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five Cameroonian edible plants namely Colocasia esculenta, Triumfetta pentandra, Hibiscus esculentus, Canarium schweinfurthii and Annona muricata against a panel of 19 multidrug resistant Gram-negative bacterial strains. The liquid broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The preliminary phytochemical screening of the extracts was conducted according to the standard phytochemical methods. Results showed that all extracts contained compounds belonging to the classes of polyphenols, triterpenes and steroids, other classes of chemicals being selectively distributed. Canarium schweinfurthii extract showed the best activity with MIC values ranging from 64 to 1024 μg/mL against 89.5% of the 19 tested bacteria strains. MIC values below or equal to 1024 μg/mL were also recorded with Triumfetta pentandra, Annona muricata, Colocasia esculenta and Hibiscus esculentus extracts respectively against 15/19 (78.9%), 11/19 (57.9%), 10/19 (52.6%) and 10/19 (52.6%) tested bacteria. Extract from C. schweinfurthii displayed the lowest MIC value (64 μg/mL) against Escherichia coli AG100ATet. Finally, the results of this work provide baseline information for the use of C. esculenta, T. pentandra, H. esculentus, C. schweinfurthii and A. muricata in the treatment of bacterial infections including multidrug resistant phenotypes.

Phenolic extracts of Centaurium erythraea with novel antiradical, antibacterial and antileishmanial activities

“…On the other hand, Gram-negative bacteria resist to natural antibacterial agents. Indeed, these strains possess a hydrophilic outer membrane which allowed them the penetration of hydrophobic compounds [53].…”

Kajian Komposisi Kimia, Nilai Nutrisi, Dan Etnofarmakologis Tanaman Genus Kenari

“…Secara etnofarmakologis pemanfaatan spesies kenari yang dilaporkan adalah memiliki aktivitas sebagai antimikroba (Koudou et al 2005;Mogana et al 2011b;Basri & Sandra 2016;Dzotam et al 2016), mengatur kadar glukosa darah (Saari et al 2017;Yeh et al, 2017), sebagai antiaterosklerosis (Shakirin et al 2012a;Shakirin et al 2012b), memiliki aktivitas sebagai antiinflamasi (Leakey et al 2008;Mogana et al 2013a;Mogana et al 2013b), memiliki aktivitas antioksidan Chew et al 2011;Djarkasi et al 2011;Prasad et al 2011;Arenas & Trinidad 2017a; Arenas & Trinidad 2017b) dan sebagai hepatoprotektif (Yeh et al 2017). Pemanfaatan delapan spesies kenari dalam pengobatan dan sebagai sumber nutrisi pangan dirangkum pada tabel 1.…”

“…Adanya asam glutamat yang banyak memberikan rasa gurih dari biji kenari. Jenis asam amino yang lengkap dalam biji CI (Djarkasi et al 2011) menunjukkan bahwa CI dapat dimanfaatkan sebagai sumber pangan fungsional karena asam amino memiliki aktivitas mengatur fungsi fisiologi manusia sehingga dapat mengatur metabolisme untuk menjaga dan meningkatkan kesehatan (Betts & Russell 2003;Wu 2013 Koudou et al 2005;Kamtchouing et al 2006;Stangeland et al 2009;Kuete et al 2015;Seukep et al 2015;Dzotam et al 2016 Uji aktivitas farmakologis secara in-vitro dari minyak biji CI menunjukkan bahwa minyak CI memiliki aktivitas menghambat produksi prostaglandin E2 sehingga memiliki aktvitas sebagai antiinflamasi (Leakey et al 2008). Aktivitas antioksidan juga ditunjukkan oleh adanya komposisi golongan tokoferol dalam biji kenari (Djarkasi et al 2011).…”

Correlation between VOC fingerprinting and antimicrobial activity of several essential oils extracted by plant resins against A. tumefaciens and P. savastanoi

“…The genus Canarium (Burseraceae family) is another group of plants that have been extensively studied and are used in traditional medicine to treat a broad array of illnesses . Pharmacological and antimicrobial activities of essential oil of Canarium schweinfurthii resin have been reported . Furthermore, the main secondary metabolites that characterize the resin oil of the genus Canarium are carboxylic acids, furan compounds, lipids and terpenes (monoterpenes, triterpenes, sesquiterpenes)…”