Antibacterial Activity against Staphylococcus Aureus of Titanium Surfaces Coated with Graphene Nanoplatelets to Prevent Peri-Implant Diseases. An In-Vitro Pilot Study

Pranno, Nicola; Monaca, Gerardo La; Polimeni, Antonella; Sarto, Maria Sabrina; Uccelletti, Daniela; Bruni, Erika; Cristalli, Maria Paola; Cavallini, Domenico; Vozza, Iole

doi:10.3390/ijerph17051568

Cited by 31 publications

(37 citation statements)

References 49 publications

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“…In particular, recent scientific breakthroughs have demonstrated that GNPs, in addition to their significant physiochemical properties, show great antimicrobial effects [ 9 ], without exerting relevant cytotoxic damages on human cell lines [ 10 ]. However, based on the available literature data, owing to the high uncertainty and the numerous conflicting outcomes about the hazardous properties of graphene nanomaterials [ 11 , 12 , 13 ] and their possible effects on humans’ health [ 14 ], specific occupational exposure limits are not yet available.…”

Section: Introductionmentioning

confidence: 99%

Workers’ Exposure Assessment during the Production of Graphene Nanoplatelets in R&D Laboratory

et al. 2020

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Widespread production and use of engineered nanomaterials in industrial and research settings raise concerns about their health impact in the workplace. In the last years, graphene-based nanomaterials have gained particular interest in many application fields. Among them, graphene nanoplatelets (GNPs) showed superior electrical, optical and thermal properties, low-cost and availability. Few and conflicting results have been reported about toxicity and potential effects on workers’ health, during the production and handling of these nanostructures. Due to this lack of knowledge, systematic approaches are needed to assess risks and quantify workers’ exposure to GNPs. This work applies a multi-metric approach to assess workers’ exposure during the production of GNPs, based on the Organization for Economic Cooperation and Development (OECD) methodology by integrating real-time measurements and personal sampling. In particular, we analyzed the particle number concentration, the average diameter and the lung deposited surface area of airborne nanoparticles during the production process conducted by thermal exfoliation in two different ways, compared to the background. These results have been integrated by electron microscopic and spectroscopic analysis on the filters sampled by personal impactors. The study identifies the process phases potentially at risk for workers and reports quantitative information about the parameters that may influence the exposure in order to propose recommendations for a safer design of GNPs production process.

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Section: Introductionmentioning

confidence: 99%

Workers’ Exposure Assessment during the Production of Graphene Nanoplatelets in R&D Laboratory

et al. 2020

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“…They have also noted that the number of attached bacteria was variable among the films, with a higher amount being found on smoother surfaces, i.e., pyrolytic graphite surfaces used as control. Pranno et al (2020) used LPE graphene to improve antimicrobial properties of titanium dental implants, commonly exposed to infections. The graphene flakes were then applied as a coating on the titanium.…”

Section: Dm Coatings and Cellular Interactionmentioning

confidence: 99%

“…The graphene flakes were then applied as a coating on the titanium. The lowest % of S. aureus biofilm formation was observed in samples with the smaller flake size (obtained with the longest sonication times) ( Pranno et al, 2020 ). Besides bacteria, a physical disruption mechanism has also been recently observed in the case of virus, again via the contact with sharp edges in graphene ( Innocenzi and Stagi, 2020 ).…”

Section: Dm Coatings and Cellular Interactionmentioning

confidence: 99%

Interactions Between 2D Materials and Living Matter: A Review on Graphene and Hexagonal Boron Nitride Coatings

Santos

Moschetta

Rodrigues

et al. 2021

Front. Bioeng. Biotechnol.

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Two-dimensional material (2DM) coatings exhibit complex and controversial interactions with biological matter, having shown in different contexts to induce bacterial cell death and contribute to mammalian cell growth and proliferation in vitro and tissue differentiation in vivo. Although several reports indicate that the morphologic and electronic properties of the coating, as well as its surface features (e.g., crystallinity, wettability, and chemistry), play a key role in the biological interaction, these kinds of interactions have not been fully understood yet. In this review, we report and classify the cellular interaction mechanisms observed in graphene and hexagonal boron nitride (hBN) coatings. Graphene and hBN were chosen as study materials to gauge the effect of two atomic-thick coatings with analogous lattice structure yet dissimilar electrical properties upon contact with living matter, allowing to discern among the observed effects and link them to specific material properties. In our analysis, we also considered the influence of crystallinity and surface roughness, detailing the mechanisms of interaction that make specific coatings of these 2DMs either hostile toward bacterial cells or innocuous for mammalian cells. In doing this, we discriminate among the material and surface properties, which are often strictly connected to the 2DM production technique, coating deposition and post-processing method. Building on this knowledge, the selection of 2DM coatings based on their specific characteristics will allow to engineer desired functionalities and devices. Antibacterial coatings to prevent biofouling, biocompatible platforms suitable for biomedical applications (e.g., wound healing, tissue repairing and regeneration, and novel biosensing devices) could be realized in the next future. Overall, a clear understanding on how the 2DM coating’s properties may modulate a specific bacterial or cellular response is crucial for any future innovation in the field.

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“…These layers are approximately 1 nm thick and 400–500 mm long, having a very high aspect ratio [ 67 ]. Several groups have investigated the GO coating of Ti implants in order to improve the osseointegration since it is biocompatible, has antibacterial properties [ 68 ] and can enhance the mechanical properties [ 69 ]. In addition, GO coatings prevent corrosion [ 70 ].…”

Section: Graphenementioning

confidence: 99%

Nanomaterials in Dentistry: State of the Art and Future Challenges

2020

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Nanomaterials are commonly considered as those materials in which the shape and molecular composition at a nanometer scale can be controlled. Subsequently, they present extraordinary properties that are being useful for the development of new and improved applications in many fields, including medicine. In dentistry, several research efforts are being conducted, especially during the last decade, for the improvement of the properties of materials used in dentistry. The objective of the present article is to offer the audience a complete and comprehensive review of the main applications that have been developed in dentistry, by the use of these materials, during the last two decades. It was shown how these materials are improving the treatments in mainly all the important areas of dentistry, such as endodontics, periodontics, implants, tissue engineering and restorative dentistry. The scope of the present review is, subsequently, to revise the main applications regarding nano-shaped materials in dentistry, including nanorods, nanofibers, nanotubes, nanospheres/nanoparticles, and zeolites and other orders porous materials. The results of the bibliographic analysis show that the most explored nanomaterials in dentistry are graphene and carbon nanotubes, and their derivatives. A detailed analysis and a comparative study of their applications show that, although they are quite similar, graphene-based materials seem to be more promising for most of the applications of interest in dentistry. The bibliographic study also demonstrated the potential of zeolite-based materials, although the low number of studies on their applications shows that they have not been totally explored, as well as other porous nanomaterials that have found important applications in medicine, such as metal organic frameworks, have not been explored. Subsequently, it is expected that the research effort will concentrate on graphene and zeolite-based materials in the coming years. Thus, the present review paper presents a detailed bibliographic study, with more than 200 references, in order to briefly describe the main achievements that have been described in dentistry using nanomaterials, compare and analyze them in a critical way, with the aim of predicting the future challenges.

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Antibacterial Activity against Staphylococcus Aureus of Titanium Surfaces Coated with Graphene Nanoplatelets to Prevent Peri-Implant Diseases. An In-Vitro Pilot Study

Cited by 31 publications

References 49 publications

Workers’ Exposure Assessment during the Production of Graphene Nanoplatelets in R&D Laboratory

Workers’ Exposure Assessment during the Production of Graphene Nanoplatelets in R&D Laboratory

Interactions Between 2D Materials and Living Matter: A Review on Graphene and Hexagonal Boron Nitride Coatings

Nanomaterials in Dentistry: State of the Art and Future Challenges

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