Antibacterial Activity and Biodegradation of Cellulose Fiber Blends with Incorporated ZnO

Malis, Domen; Jeršek, Barbara; Tomšič, Brigita; Štular, Danaja; Golja, Barbara; Kapun, Gregor; Simončić, Barbara

doi:10.3390/ma12203399

Cited by 32 publications

(14 citation statements)

References 30 publications

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“…The mechanism for antimicrobial effect is not well known, although it could be due to the binding of ZnO particles on the bacterial surface through electrostatic forces [47], disruption of cell membrane with loss of its functionality [48], and generation of hydrogen peroxide [49]. It was demonstrated that the ZnO nanoparticles structure, chemical composition and morphology play a crucial role in antimicrobial activity [50]: Zn 2+ cations, released from ZnO nanorods dissolution in water, are able to interact with different bacterial target sites [51,52]. The higher surface area of nanostructures with respect to that of bulk materials can promote a faster ion release in water or physiological solutions.…”

Section: Discussionmentioning

confidence: 99%

Optimization of ZnO Nanorods Growth on Polyetheresulfone Electrospun Mats to Promote Antibacterial Properties

et al. 2020

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Zinc oxide (ZnO) nanorods grown by chemical bath deposition (CBD) on the surface of polyetheresulfone (PES) electrospun fibers confer antimicrobial properties to the obtained hybrid inorganic-polymeric PES/ZnO mats. In particular, a decrement of bacteria colony forming units (CFU) is observed for both negative (Escherichia coli) and positive (Staphylococcus aureus and Staphylococcus epidermidis) Grams. Since antimicrobial action is strictly related to the quantity of ZnO present on surface, a CBD process optimization is performed to achieve the best results in terms of coverage uniformity and reproducibility. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) provide morphological and compositional analysis of PES/ZnO mats while thermogravimetric analysis (TGA) is useful to assess the best process conditions to guarantee the higher amount of ZnO with respect to PES scaffold. Biocidal action is associated to Zn 2+ ion leaching in solution, easily indicated by UV-Vis measurement of metallation of free porphyrin layers deposited on glass.A wide selection of polymers can be used to produce fibrous scaffolds and surface functionalization or material doping tailor their composition for specific applications, spanning from biomedicine to environmental remediation [3][4][5][6][7]. In this perspective, polymeric nanofibers are often combined with other classes of materials-i.e., inorganic nanostructures and/or organic molecules-to achieve specific deliverable highlights. Combination of polymeric mats with semiconducting oxides, as zinc oxide and titanium oxide (ZnO, TiO2), improves mats performances by adding multifunctionalities such as photocatalytic properties and sensing actions [8,9].Antibacterial properties of fibrous mats are currently under investigation [10-13] to provide innovative materials against bacteria surface contamination that causes severe infection and human health treats: in fact, microorganism colonies-responsible for biofilm formation-are developing an antibiotic resistance that makes this kind of contamination difficult to eradicate.Both Gram-positive and Gram-negative bacteria are able to form biofilms [14], which represent the major causative agent of chronic and recurrent diseases [15,16]: in fact, it is estimated that more than 80% of human infections are biofilm-related [17,18]. In addition, the surfaces of commonly used prosthetic components-such as steel, titanium, and polymeric biomaterial-are susceptible to colonization of biofilm-forming bacterial species [19]. Antibiotics are often ineffective against biofilm-producing bacteria, due to their reduced growth rate and different gene expression [20,21]. It is well known that ZnO particles show antimicrobial activity against both Gram-positive and Gram-negative bacteria [22][23][24][25].Recently, antimicrobial behavior of hybrid polymeric-inorganic materials is under investigation: however, literature refers to incorporation of ZnO inside the fibers by electrospinning of nanoparticles dispersion inside polymeric mat...

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Section: Discussionmentioning

confidence: 99%

Optimization of ZnO Nanorods Growth on Polyetheresulfone Electrospun Mats to Promote Antibacterial Properties

et al. 2020

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“…The outstanding antimicrobial activity of the PCL/CS/ZnO composite coating was due to the synergistic antimicrobial properties of CS and ZnO NPs. This result in the production of reactive oxygen species (ROS) like H 2 O 2 , where CS electrostatically binds to the bacterial cell wall while ZnO NPs interact with protein membrane, resulting in the intracellular released material and perforated cell membrane [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50].…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Improved Bacteriostatic and Anticorrosion Effects of Polycaprolactone/Chitosan Coated Magnesium via Incorporation of Zinc Oxide

et al. 2021

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Magnesium has been recognized as a groundbreaking biodegradable biomaterial for implant applications, but its use is limited because it degrades too quickly in physiological solutions. This paper describes the research on the influence of polycaprolactone (PCL)/chitosan (CS)/zinc oxide (ZnO) composite coating (PCL/CS/ZnO) on the corrosion resistance and antibacterial activity of magnesium. The PCL/CS film presented a porous structure with thickness of about 40–50 μm, while after incorporation of ZnO into the PCL/CS, a homogenous film without pores and defects was attained. The ZnO embedded in PCL/CS enhanced corrosion resistance by preventing corrosive ions diffusion in the magnesium substrate. The corrosion, antibacterial, and cell interaction mechanism of the PCL/CS/ZnO composite coating is discussed in this study. In vitro cell culture revealed that the PCL/CS coating with low loaded ZnO significantly improved cytocompatibility, but coatings with high loaded ZnO were able to induce some cytotoxicity osteoblastic cells. It was also found that enhanced antibacterial activity of the PCL/CS/ZnO coating against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, while less significant antibacterial activity was detected for uncoated Mg and PCL/CS coating. Based on the results, the PCL/CS coatings loaded with low ZnO content may be recommended as a candidate material for biodegradable Mg-based orthopedic implant applications.

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“…These include some of the oldest man-made materials, such as textiles. Today, the word design is more relevant to them than ever before, because smart textiles have a great future utilization in healthcare [1][2][3], medicine [4][5][6][7][8], transport [9,10], sports and leisure [11,12], safety and personal protective equipment [13], construction [14], interior design [15,16], agriculture [17], sensors and biosensors [18][19][20], etc. Materials creation is associated with combining their known properties with new functionality to ensure active interaction with the environment, i.e., ability to react and adapt to changes [21].…”

Section: Introductionmentioning

confidence: 99%

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

2021

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Textile materials, as a suitable matrix for different active substances facilitating their gradual release, can have an important role in skin topical or transdermal therapy. Characterized by compositional and structural variety, those materials readily meet the requirements for applications in specific therapies. Aromatherapy, antimicrobial substances and painkillers, hormone therapy, psoriasis treatment, atopic dermatitis, melanoma, etc., are some of the areas where textiles can be used as carriers. There are versatile optional methods for loading the biologically active substances onto textile materials. The oldest ones are by exhaustion, spraying, and a pad-dry-cure method. Another widespread method is the microencapsulation. The modification of textile materials with stimuli-responsive polymers is a perspective route to obtaining new textiles of improved multifunctional properties and intelligent response. In recent years, research has focused on new structures such as dendrimers, polymer micelles, liposomes, polymer nanoparticles, and hydrogels. Numerous functional groups and the ability to encapsulate different substances define dendrimer molecules as promising carriers for drug delivery. Hydrogels are also high molecular hydrophilic structures that can be used to modify textile material. They absorb a large amount of water or biological fluids and can support the delivery of medicines. These characteristics correspond to one of the current trends in the development of materials used in transdermal therapy, namely production of intelligent materials, i.e., such that allow controlled concentration and time delivery of the active substance and simultaneous visualization of the process, which can only be achieved with appropriate and purposeful modification of the textile material.

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Antibacterial Activity and Biodegradation of Cellulose Fiber Blends with Incorporated ZnO

Cited by 32 publications

References 30 publications

Optimization of ZnO Nanorods Growth on Polyetheresulfone Electrospun Mats to Promote Antibacterial Properties

Optimization of ZnO Nanorods Growth on Polyetheresulfone Electrospun Mats to Promote Antibacterial Properties

Improved Bacteriostatic and Anticorrosion Effects of Polycaprolactone/Chitosan Coated Magnesium via Incorporation of Zinc Oxide

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

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