Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption

Polaquini, Carlos Roberto; Marques, Beatriz Carvalho; Ayusso, Gabriela Miranda; Morão, Luana Galvão; Sardi, Janaína de Cássia Orlandi; Campos, Denise; Silva, Isabel Cristiane da; Cavalca, L.; Scheffers, Dirk‐Jan; Rosalen, Pedro Luiz; Pavan, Fernando Rogério; Ferreira, Henrique; Regasini, Luís Octávio

doi:10.1016/j.bioorg.2021.104668

Cited by 12 publications

(9 citation statements)

References 70 publications

(94 reference statements)

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“…In an attempt to overcome increased antibacterial resistance, research into structural modifications of natural products to enhance their biological activities has been conducted (▶ Table 1). Due to its already well-established pharmacological activities, cur-cuminʼs structure has been studied and synthetically modified to form curcumin analogues to further enhance these antibacterial activities [28][29][30][31][32][33][34][35].…”

Section: Antibacterial Activity Of Curcumin Analoguesmentioning

confidence: 99%

Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues

Denison,

Schwikkard,

Khoder

et al. 2023

Planta Med

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Antimicrobial resistance is a global challenge that is already exacting a heavy price both in terms of human health and financial cost. Novel ways of approaching this crisis include the investigation of natural products. Curcumin is the major constituent in turmeric, and it is commonly used in the preparation of Asian cuisine. In addition, it possesses a wide range of pharmacological properties. This review provides a detailed account of curcumin and its analogues’ antibacterial activity against both Gram-positive and Gram-negative isolates, including its potential mechanism(s) of action and the safety and toxicity in human and animal models. We also highlight the key challenges in terms of solubility/bioavailability associated with the use of curcumin and include research on how these challenges have been overcome.

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Section: Antibacterial Activity Of Curcumin Analoguesmentioning

confidence: 99%

Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues

Denison,

Schwikkard,

Khoder

et al. 2023

Planta Med

View full text Add to dashboard Cite

show abstract

“…It was found that these derivatives at (MIC 90 = 7.8-27.9 μg/ml) were able to inhibit MTB growth. 117 To overcome the limited stability and pharmacokinetics associated with curcumin, Polaquini et al 118 synthesized a MACs having enhanced and broad-spectrum antibacterial activity against MTB, MRSA, and A. baumannii having MIC values lying between 0.9 and 15.6 μg/ml. 118 Future studies of this reported potential isomeric forms of curcumin and their principle of interaction with MTB may be carried out and compared with that of native crude curcumin, which may be helpful in future design and synthesis of highly efficient anti-MTB synthetic drug derived from curcumin.…”

Section: Curcumin and Its Important Nanoformulations Against Mtb Infe...mentioning

confidence: 99%

“…It was found that these derivatives at (MIC 90 = 7.8–27.9 μg/ml) were able to inhibit MTB growth 117 . To overcome the limited stability and pharmacokinetics associated with curcumin, Polaquini et al 118 . synthesized a MACs having enhanced and broad‐spectrum antibacterial activity against MTB , MRSA, and A. baumannii having MIC values lying between 0.9 and 15.6 μg/ml 118 .…”

Section: Curcumin and Its Important Nanoformulations Against Mtb Infe...mentioning

confidence: 99%

“…Curcumin nanocomplex aerosols and crude curcumin (along with blue LED light‐activated EDTA) have the potential to inhibit B. cepacia growth by mechanism that includes bacterial DNA and protein damage and intracellular content leakage 103–109 . In case of MTB infection, curcumin and its important nanoformulations can cure tuberculosis by directly inhibiting MTB growth as well as modulating the host immune response for immune‐mediated MTB clearance 110–120 . Antibacterial activity of curcumin and its nanoconjugates against A. baumannii is mediated by ROS building, disruption of outer membrane, inhibition of drug efflux pumps, and biofilm response regulator 122–128 .…”

Section: Mechanism Of Antibacterial Activity Of Curcumin Its Essentia...mentioning

confidence: 99%

“…[103][104][105][106][107][108][109] In case of MTB infection, curcumin and its important nanoformulations can cure tuberculosis by directly inhibiting MTB growth as well as modulating the host immune response for immune-mediated MTB clearance. [110][111][112][113][114][115][116][117][118][119][120] Antibacterial activity of curcumin and its nanoconjugates against A. baumannii is mediated by ROS building, disruption of outer membrane, inhibition of drug efflux pumps, and biofilm response regulator. [122][123][124][125][126][127][128] Curcumin and its various nanoformulations exhibit efficient antibacterial activity against S. mutans in the presence of blue light PDT by ROS generation and bacterial membrane impairment.…”

Section: Mechanism Of Antibacterial Activity Of Curcumin Its Essentia...mentioning

confidence: 99%

See 2 more Smart Citations

Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review

Shome

Talukdar

Upadhyaya

2021

Biotech and App Biochem

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Multidrug‐resistant bacterial infections can kill 700,000 individuals globally each year and is considered among the top 10 global health threats faced by humanity as the arsenal of antibiotics is becoming dry and alternate antibacterial molecule is in demand. Nanoparticles of curcumin exhibit appreciable broad‐spectrum antibacterial activity using unique and novel mechanisms and thus the process deserves to be reviewed and further researched to clearly understand the mechanisms. Based on the antibiotic resistance, infection, and virulence potential, a list of clinically important bacteria was prepared after extensive literature survey and all recent reports on the antibacterial activity of curcumin and its nanoformulations as well as their mechanism of antibacterial action have been reviewed. Curcumin, nanocurcumin, and its nanocomposites with improved aqueous solubility and bioavailability are very potential, reliable, safe, and sustainable antibacterial molecule against clinically important bacterial species that uses multitarget mechanism such as inactivation of antioxidant enzyme, reactive oxygen species‐mediated cellular damage, and inhibition of acyl‐homoserine‐lactone synthase necessary for quorum sensing and biofilm formation, thereby bypassing the mechanisms of bacterial antibiotic resistance. Nanoformulations of curcumin can thus be considered as a potential and sustainable antibacterial drug candidate to address the issue of antibiotic resistance.

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Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

Ramli,

Mohd Faudzi

2023

Archiv der Pharmazie

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Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public health and the economy and have been recognized as a major cause of morbidity and mortality, particularly in Southeast Asia. Infectious disease control is a major challenge, but many surveillance systems and control strategies have been developed and implemented. These include vector control, combination therapies, vaccine development, and the development of new anti‐infectives. Numerous newly discovered agents with pharmacological anti‐infective potential are being actively and extensively studied for their bioactivity, toxicity, selectivity, and mode of action, but many molecules lose their efficacy over time due to resistance developments. These facts justify the great importance of the search for new, effective, and safe anti‐infectives. Diarylpentanoids, a curcumin derivative, have been developed as an alternative with better bioavailability and metabolism as a therapeutic agent. In this review, the mechanisms of action and potential targets of antimalarial drugs as well as the classes of antimalarial drugs are presented. The bioactivity of diarylpentanoids as a potential scaffold for a new class of anti‐infectives and their structure–activity relationships are also discussed in detail.

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Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption

Abstract: Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption. Bioorganic Chemistry, 109, [104668].

Cited by 12 publications

References 70 publications

Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues

Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues

Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review

Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

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